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Neonatal and maternal concentrations of hydroxil radical and total antioxidant system: protective role of placenta against fetal oxidative stress.

Abstract

BACKGROUND

Reactive oxygen species (ROS) may cause peroxydation of lipids, proteins and deoxyribonucleic acids with subsequent cell damage. The hydroxyl radical (OH*) represents a measure of global oxidative stress. Hydroxyl radicals are short-lived; they form an important part of radical chemistry nonetheless. The measure of total antioxidant system (TAS) can give useful information about the extent of defence capable of counteracting the oxidative damage. Pregnancy is an important condition that favors oxidative stress in the fetus. Clinical studies indicate a protective mechanism against O2 toxicity in the human feto-placental unit.

AIM

This study reports the OH* and TAS concentrations in mother and fetus at birth to evaluate the role of the placenta against fetal oxidative stress.

METHODS

Blood samples were collected at delivery from 45 healthy women at term and from their newborns. The maternal and neonatal OH* and TAS concentrations were compared by paired Student t-test.

RESULTS

OH* was higher in maternal blood than in cord blood (573.75+/- 170.0 UCarr/l vs 40.08+/-33.37 UCarr/l) (p<0.01); TAS concentrations did not differ between the two groups (1.11+/-0.09 mmol/l vs 1.17+/-0.12 mmol/l). Multiple regression analyses: maternal and neonatal OH* decreases with maternal age; only maternal TAS and OH* are related to gestational age in a nonlinear fashion. Female infants showed higher values of maternal and neonatal TAS as compared to male infants.

CONCLUSION

TA protective role of the placenta against oxidative damage is in keeping with a large enough gradient of ROS (between mother and fetus) and the passage of TAS from mother to fetus.

Authors+Show Affiliations

,

Department of Neonatology, ICP, NICU, Milan, Italy. g.lista@icp.mi.it

, , , ,

Source

Neuro endocrinology letters 31:3 2010 pg 319-24

MeSH

Adult
Antioxidants
Circadian Rhythm
Female
Fetal Blood
Gestational Age
Humans
Hydroxyl Radical
Infant, Newborn
Male
Oxidative Stress
Parturition
Placenta
Pregnancy

Pub Type(s)

Journal Article

Language

eng

PubMed ID

20588236

Citation

Lista, Gianluca, et al. "Neonatal and Maternal Concentrations of Hydroxil Radical and Total Antioxidant System: Protective Role of Placenta Against Fetal Oxidative Stress." Neuro Endocrinology Letters, vol. 31, no. 3, 2010, pp. 319-24.
Lista G, Castoldi F, Compagnoni G, et al. Neonatal and maternal concentrations of hydroxil radical and total antioxidant system: protective role of placenta against fetal oxidative stress. Neuro Endocrinol Lett. 2010;31(3):319-24.
Lista, G., Castoldi, F., Compagnoni, G., Maggioni, C., Cornélissen, G., & Halberg, F. (2010). Neonatal and maternal concentrations of hydroxil radical and total antioxidant system: protective role of placenta against fetal oxidative stress. Neuro Endocrinology Letters, 31(3), pp. 319-24.
Lista G, et al. Neonatal and Maternal Concentrations of Hydroxil Radical and Total Antioxidant System: Protective Role of Placenta Against Fetal Oxidative Stress. Neuro Endocrinol Lett. 2010;31(3):319-24. PubMed PMID: 20588236.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Neonatal and maternal concentrations of hydroxil radical and total antioxidant system: protective role of placenta against fetal oxidative stress. AU - Lista,Gianluca, AU - Castoldi,Francesca, AU - Compagnoni,Gilberto, AU - Maggioni,Cristina, AU - Cornélissen,Germaine, AU - Halberg,Franz, PY - 2010/03/11/received PY - 2010/05/02/accepted PY - 2010/7/1/entrez PY - 2010/7/1/pubmed PY - 2010/10/12/medline SP - 319 EP - 24 JF - Neuro endocrinology letters JO - Neuro Endocrinol. Lett. VL - 31 IS - 3 N2 - BACKGROUND: Reactive oxygen species (ROS) may cause peroxydation of lipids, proteins and deoxyribonucleic acids with subsequent cell damage. The hydroxyl radical (OH*) represents a measure of global oxidative stress. Hydroxyl radicals are short-lived; they form an important part of radical chemistry nonetheless. The measure of total antioxidant system (TAS) can give useful information about the extent of defence capable of counteracting the oxidative damage. Pregnancy is an important condition that favors oxidative stress in the fetus. Clinical studies indicate a protective mechanism against O2 toxicity in the human feto-placental unit. AIM: This study reports the OH* and TAS concentrations in mother and fetus at birth to evaluate the role of the placenta against fetal oxidative stress. METHODS: Blood samples were collected at delivery from 45 healthy women at term and from their newborns. The maternal and neonatal OH* and TAS concentrations were compared by paired Student t-test. RESULTS: OH* was higher in maternal blood than in cord blood (573.75+/- 170.0 UCarr/l vs 40.08+/-33.37 UCarr/l) (p<0.01); TAS concentrations did not differ between the two groups (1.11+/-0.09 mmol/l vs 1.17+/-0.12 mmol/l). Multiple regression analyses: maternal and neonatal OH* decreases with maternal age; only maternal TAS and OH* are related to gestational age in a nonlinear fashion. Female infants showed higher values of maternal and neonatal TAS as compared to male infants. CONCLUSION: TA protective role of the placenta against oxidative damage is in keeping with a large enough gradient of ROS (between mother and fetus) and the passage of TAS from mother to fetus. SN - 0172-780X UR - https://www.unboundmedicine.com/medline/citation/20588236/Neonatal_and_maternal_concentrations_of_hydroxil_radical_and_total_antioxidant_system:_protective_role_of_placenta_against_fetal_oxidative_stress_ L2 - https://medlineplus.gov/antioxidants.html DB - PRIME DP - Unbound Medicine ER -