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Complement components (C3, C4) as inflammatory markers in asthma.

Abstract

OBJECTIVE

To assess the serum levels of complement factors C3 and C4 in Egyptian asthmatic children.

METHODS

This case-controlled study comprised of 60 Egyptian children with the diagnosis of bronchial asthma (not in acute attack) and 60 age-and sex-matched healthy controls. All candidates were subjected to a thorough clinical study, complete blood counts, absolute eosinophil count and serum complements (C3, C4).

RESULTS

Serum C3 was significantly higher in asthmatics when compared to controls (140.60 +/- 38.80 mg/dl vs 107.70 +/- 45.00 mg/dl respectively, (p = 0.01). However, differences in serum C4 levels were not significant (41.30+/-48.80 mg/dl vs 44.60 +/- 39.70 mg/dl respectively, p = 0.69). There was a significant positive correlation between severity of asthma and serum C3 (p=0.02) but not with serum C4.

CONCLUSIONS

Serum levels of C3 - but not C4 - are elevated in children with stable asthma, with a positive correlation between serum C3 and severity of asthma.

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  • Publisher Full Text
  • Authors

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    Source

    Indian journal of pediatrics 77:7 2010 Jul pg 771-3

    MeSH

    Asthma
    Biological Markers
    Case-Control Studies
    Child, Preschool
    Complement C3
    Complement C4
    Egypt
    Female
    Humans
    Male
    Matched-Pair Analysis
    Severity of Illness Index

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    20589464