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Caffeine and stress alter salivary alpha-amylase activity in young men.
Hum Psychopharmacol. 2010 Jul; 25(5):359-67.HP

Abstract

OBJECTIVE

We examined the effects of caffeine and a psychological stressor on salivary alpha-amylase (sAA) in healthy young males (age 18-30 years) who consumed caffeine on a daily basis.

METHODS

Using a between-subjects, double-blind, placebo-controlled design, 45 participants received either 200 or 400 mg of caffeine (Vivarin) or placebo, rested for 20 min, and then performed 20 min of mental arithmetic. Saliva samples (assayed for sAA and caffeine), blood pressure, and heart rate were taken before (baseline) and 15 min after the math stressor (stress).

RESULTS

Baseline sAA activity did not differ among the treatment groups; however, there was a statistically significant time by caffeine group interaction. Changes in sAA activity across the session were dependent on the amount of caffeine consumed. Following the challenge period, sAA activity among the placebo group was the lowest and sAA activity among the 400 mg treatment group was the highest. Separate repeated-measures ANOVAs conducted for each drug treatment group revealed that sAA activity increased in response to stress and caffeine (i.e., 200 and 400 mg groups) but not to stress alone (i.e., placebo group).

CONCLUSIONS

Findings provide evidence for acute sAA changes in response to caffeine and stress in habitual caffeine users.

Authors+Show Affiliations

Department of Biobehavioral Health, Pennsylvania State University, University Park, PA 16802, USA. lcklein@psu.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

20589924

Citation

Klein, Laura C., et al. "Caffeine and Stress Alter Salivary Alpha-amylase Activity in Young Men." Human Psychopharmacology, vol. 25, no. 5, 2010, pp. 359-67.
Klein LC, Bennett JM, Whetzel CA, et al. Caffeine and stress alter salivary alpha-amylase activity in young men. Hum Psychopharmacol. 2010;25(5):359-67.
Klein, L. C., Bennett, J. M., Whetzel, C. A., Granger, D. A., & Ritter, F. E. (2010). Caffeine and stress alter salivary alpha-amylase activity in young men. Human Psychopharmacology, 25(5), 359-67. https://doi.org/10.1002/hup.1126
Klein LC, et al. Caffeine and Stress Alter Salivary Alpha-amylase Activity in Young Men. Hum Psychopharmacol. 2010;25(5):359-67. PubMed PMID: 20589924.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Caffeine and stress alter salivary alpha-amylase activity in young men. AU - Klein,Laura C, AU - Bennett,Jeanette M, AU - Whetzel,Courtney A, AU - Granger,Douglas A, AU - Ritter,Frank E, PY - 2010/7/1/entrez PY - 2010/7/1/pubmed PY - 2010/10/12/medline SP - 359 EP - 67 JF - Human psychopharmacology JO - Hum Psychopharmacol VL - 25 IS - 5 N2 - OBJECTIVE: We examined the effects of caffeine and a psychological stressor on salivary alpha-amylase (sAA) in healthy young males (age 18-30 years) who consumed caffeine on a daily basis. METHODS: Using a between-subjects, double-blind, placebo-controlled design, 45 participants received either 200 or 400 mg of caffeine (Vivarin) or placebo, rested for 20 min, and then performed 20 min of mental arithmetic. Saliva samples (assayed for sAA and caffeine), blood pressure, and heart rate were taken before (baseline) and 15 min after the math stressor (stress). RESULTS: Baseline sAA activity did not differ among the treatment groups; however, there was a statistically significant time by caffeine group interaction. Changes in sAA activity across the session were dependent on the amount of caffeine consumed. Following the challenge period, sAA activity among the placebo group was the lowest and sAA activity among the 400 mg treatment group was the highest. Separate repeated-measures ANOVAs conducted for each drug treatment group revealed that sAA activity increased in response to stress and caffeine (i.e., 200 and 400 mg groups) but not to stress alone (i.e., placebo group). CONCLUSIONS: Findings provide evidence for acute sAA changes in response to caffeine and stress in habitual caffeine users. SN - 1099-1077 UR - https://www.unboundmedicine.com/medline/citation/20589924/Caffeine_and_stress_alter_salivary_alpha_amylase_activity_in_young_men_ L2 - https://doi.org/10.1002/hup.1126 DB - PRIME DP - Unbound Medicine ER -