Tags

Type your tag names separated by a space and hit enter

A facile construction of bi- or tricyclic skeletons by nickel-catalyzed stereoselective cyclization of alkynylcycloalkanone.
Org Lett. 2010 Aug 06; 12(15):3494-7.OL

Abstract

A nickel-catalyzed intramolecular cyclization of alkynylalkanone in the presence of Et(3)SiH using an NHC ligand produced various carbo- and heterocycles in a stereoselective manner. The reaction would proceed via formation of oxanickelacycle followed by sigma-bond metathesis with silane to give a bi- or tricyclic compound.

Links

Publisher Full Text (DOI)

Authors+Show Affiliations

Saito N
Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan.
Sugimura Y
No affiliation info available
Sato Y
No affiliation info available

MeSH

AlkynesCatalysisCombinatorial Chemistry TechniquesCyclizationHeterocyclic CompoundsKetonesMolecular StructureNickelSilanesStereoisomerism

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20590086

Citation

Saito, Nozomi, et al. "A Facile Construction of Bi- or Tricyclic Skeletons By Nickel-catalyzed Stereoselective Cyclization of Alkynylcycloalkanone." Organic Letters, vol. 12, no. 15, 2010, pp. 3494-7.
Saito N, Sugimura Y, Sato Y. A facile construction of bi- or tricyclic skeletons by nickel-catalyzed stereoselective cyclization of alkynylcycloalkanone. Org Lett. 2010;12(15):3494-7.
Saito, N., Sugimura, Y., & Sato, Y. (2010). A facile construction of bi- or tricyclic skeletons by nickel-catalyzed stereoselective cyclization of alkynylcycloalkanone. Organic Letters, 12(15), 3494-7. https://doi.org/10.1021/ol101329d
Saito N, Sugimura Y, Sato Y. A Facile Construction of Bi- or Tricyclic Skeletons By Nickel-catalyzed Stereoselective Cyclization of Alkynylcycloalkanone. Org Lett. 2010 Aug 6;12(15):3494-7. PubMed PMID: 20590086.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A facile construction of bi- or tricyclic skeletons by nickel-catalyzed stereoselective cyclization of alkynylcycloalkanone. AU - Saito,Nozomi, AU - Sugimura,Yasuyuki, AU - Sato,Yoshihiro, PY - 2010/7/2/entrez PY - 2010/7/2/pubmed PY - 2010/11/3/medline SP - 3494 EP - 7 JF - Organic letters JO - Org Lett VL - 12 IS - 15 N2 - A nickel-catalyzed intramolecular cyclization of alkynylalkanone in the presence of Et(3)SiH using an NHC ligand produced various carbo- and heterocycles in a stereoselective manner. The reaction would proceed via formation of oxanickelacycle followed by sigma-bond metathesis with silane to give a bi- or tricyclic compound. SN - 1523-7052 UR - https://www.unboundmedicine.com/medline/citation/20590086/A_facile_construction_of_bi__or_tricyclic_skeletons_by_nickel_catalyzed_stereoselective_cyclization_of_alkynylcycloalkanone_ L2 - https://doi.org/10.1021/ol101329d DB - PRIME DP - Unbound Medicine ER -