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[Iron deficiency and overload. Implications in oxidative stress and cardiovascular health].
Nutr Hosp. 2010 May-Jun; 25(3):350-65.NH

Abstract

Although iron is an essential mineral for maintaining good health, excessive amounts are toxic. Nowadays, much interest is focused on the mechanisms and regulation of iron metabolism by down-regulation of the hormone hepcidin. The HAMP gene encodes for hepcidin appears to be exceptionally preserved. Disorders of iron metabolism could lead to iron overload, mainly causing the rare disease hereditary hemochromatosis, or on the other hand, iron deficiency and iron deficiency anaemia. Currently, these alterations constitute an important problem of public health. The genetic variation implicated in iron overload and iron deficiency anaemia, involves mutations in several genes such as HFE, TFR2,HAMP, HJV, Tf and TMPRSS6. Iron has the capacity to accept and donate electrons easily and can catalyze reactions of free radicals production. Therefore, iron overload causes lipid peroxidation and increases cardiovascular risk. Recently, a relationship between iron metabolism and insulin resistance and obesity has been described. In contrast, regarding a possible relationship between iron deficiency anaemia and cardiovascular disease, many aspects remain controversial. This review presents an overview of the most recent information concerning iron metabolism, iron bioavailability and iron overload/deficiency related diseases. The relation between iron and cardiovascular risk, in iron overload and in iron deficiency situations, is also examined. Finally, strategies to modify dietary iron bioavailability in order to prevent iron deficiency or alleviate iron overload are suggested.

Authors+Show Affiliations

Departamento de Metabolismo y Nutrición, Instituto de Ciencia y Tecnología de Alimentos y Nutrición (ICTAN), Instituto del Frío, Consejo Superior de Investigaciones Científicas (CSIC), Madrid, Spain.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't
Review

Language

spa

PubMed ID

20593115

Citation

Toxqui, L, et al. "[Iron Deficiency and Overload. Implications in Oxidative Stress and Cardiovascular Health]." Nutricion Hospitalaria, vol. 25, no. 3, 2010, pp. 350-65.
Toxqui L, De Piero A, Courtois V, et al. [Iron deficiency and overload. Implications in oxidative stress and cardiovascular health]. Nutr Hosp. 2010;25(3):350-65.
Toxqui, L., De Piero, A., Courtois, V., Bastida, S., Sánchez-Muniz, F. J., & Vaquero, M. P. (2010). [Iron deficiency and overload. Implications in oxidative stress and cardiovascular health]. Nutricion Hospitalaria, 25(3), 350-65.
Toxqui L, et al. [Iron Deficiency and Overload. Implications in Oxidative Stress and Cardiovascular Health]. Nutr Hosp. 2010 May-Jun;25(3):350-65. PubMed PMID: 20593115.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Iron deficiency and overload. Implications in oxidative stress and cardiovascular health]. AU - Toxqui,L, AU - De Piero,A, AU - Courtois,V, AU - Bastida,S, AU - Sánchez-Muniz,F J, AU - Vaquero,Ma P, PY - 2009/11/02/received PY - 2009/11/14/accepted PY - 2010/7/2/entrez PY - 2010/7/2/pubmed PY - 2011/2/2/medline SP - 350 EP - 65 JF - Nutricion hospitalaria JO - Nutr Hosp VL - 25 IS - 3 N2 - Although iron is an essential mineral for maintaining good health, excessive amounts are toxic. Nowadays, much interest is focused on the mechanisms and regulation of iron metabolism by down-regulation of the hormone hepcidin. The HAMP gene encodes for hepcidin appears to be exceptionally preserved. Disorders of iron metabolism could lead to iron overload, mainly causing the rare disease hereditary hemochromatosis, or on the other hand, iron deficiency and iron deficiency anaemia. Currently, these alterations constitute an important problem of public health. The genetic variation implicated in iron overload and iron deficiency anaemia, involves mutations in several genes such as HFE, TFR2,HAMP, HJV, Tf and TMPRSS6. Iron has the capacity to accept and donate electrons easily and can catalyze reactions of free radicals production. Therefore, iron overload causes lipid peroxidation and increases cardiovascular risk. Recently, a relationship between iron metabolism and insulin resistance and obesity has been described. In contrast, regarding a possible relationship between iron deficiency anaemia and cardiovascular disease, many aspects remain controversial. This review presents an overview of the most recent information concerning iron metabolism, iron bioavailability and iron overload/deficiency related diseases. The relation between iron and cardiovascular risk, in iron overload and in iron deficiency situations, is also examined. Finally, strategies to modify dietary iron bioavailability in order to prevent iron deficiency or alleviate iron overload are suggested. SN - 1699-5198 UR - https://www.unboundmedicine.com/medline/citation/20593115/[Iron_deficiency_and_overload__Implications_in_oxidative_stress_and_cardiovascular_health]_ L2 - https://ClinicalTrials.gov/search/term=20593115 [PUBMED-IDS] DB - PRIME DP - Unbound Medicine ER -