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Prevalence of overlaps between GERD, FD and IBS and impact on health-related quality of life.
J Gastroenterol Hepatol. 2010 Jun; 25(6):1151-6.JG

Abstract

OBJECTIVE

Gastroesophageal reflux disease (GERD), functional dyspepsia (FD), and irritable bowel syndrome (IBS) are common, and have negative impacts on health-related quality of life (HR-QOL). Several studies demonstrated a significant overlap between two of these three diseases. The purpose of this study was to examine the prevalence of GERD, FD, and IBS, their overlap rates, and HR-QOL for each disease and each overlap compared with healthy controls in the Japanese general population.

METHODS

We performed a cross-sectional study of Japanese workers who visited a clinic for a routine health check-up, and asked them to fill out a self-report questionnaire. Prevalence and overlap rate of GERD defined as heartburn and/or acid regurgitation at least weekly, FD and IBS based on Rome III criteria, and HR-QOL by SF-8 were examined.

RESULTS

Of the 2680 eligible subjects, 207 (7.7%) were diagnosed as having GERD, 269 (10.0%) as FD, and 381 (14.2%) as IBS. Overlaps were found in 46.9% in GERD, 47.6% in FD, and 34.4% in IBS. Prevalence of overlaps in subjects with IBS was significantly lower compared with those among GERD or FD. Sufferers from GERD, FD, or IBS reported significantly poorer HR-QOL across all domains compared with controls. Overlaps significantly worsened HR-QOL in most domains except in the 'role emotional' domain. HR-QOL was particularly poor in the physical component summary for overlapping GERD and in the mental component summary for overlapping IBS.

CONCLUSION

Overlaps among GERD, FD and IBS were common and worsened HR-QOL in Japanese general population.

Authors+Show Affiliations

Department of Gastroenterology, Osaka City University Graduate School of Medicine, Osaka, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

20594232

Citation

Kaji, Makiko, et al. "Prevalence of Overlaps Between GERD, FD and IBS and Impact On Health-related Quality of Life." Journal of Gastroenterology and Hepatology, vol. 25, no. 6, 2010, pp. 1151-6.
Kaji M, Fujiwara Y, Shiba M, et al. Prevalence of overlaps between GERD, FD and IBS and impact on health-related quality of life. J Gastroenterol Hepatol. 2010;25(6):1151-6.
Kaji, M., Fujiwara, Y., Shiba, M., Kohata, Y., Yamagami, H., Tanigawa, T., Watanabe, K., Watanabe, T., Tominaga, K., & Arakawa, T. (2010). Prevalence of overlaps between GERD, FD and IBS and impact on health-related quality of life. Journal of Gastroenterology and Hepatology, 25(6), 1151-6. https://doi.org/10.1111/j.1440-1746.2010.06249.x
Kaji M, et al. Prevalence of Overlaps Between GERD, FD and IBS and Impact On Health-related Quality of Life. J Gastroenterol Hepatol. 2010;25(6):1151-6. PubMed PMID: 20594232.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prevalence of overlaps between GERD, FD and IBS and impact on health-related quality of life. AU - Kaji,Makiko, AU - Fujiwara,Yasuhiro, AU - Shiba,Masatsugu, AU - Kohata,Yukie, AU - Yamagami,Hirokazu, AU - Tanigawa,Tetsuya, AU - Watanabe,Kenji, AU - Watanabe,Toshio, AU - Tominaga,Kazunari, AU - Arakawa,Tetsuo, PY - 2010/7/3/entrez PY - 2010/7/3/pubmed PY - 2010/10/20/medline SP - 1151 EP - 6 JF - Journal of gastroenterology and hepatology JO - J. Gastroenterol. Hepatol. VL - 25 IS - 6 N2 - OBJECTIVE: Gastroesophageal reflux disease (GERD), functional dyspepsia (FD), and irritable bowel syndrome (IBS) are common, and have negative impacts on health-related quality of life (HR-QOL). Several studies demonstrated a significant overlap between two of these three diseases. The purpose of this study was to examine the prevalence of GERD, FD, and IBS, their overlap rates, and HR-QOL for each disease and each overlap compared with healthy controls in the Japanese general population. METHODS: We performed a cross-sectional study of Japanese workers who visited a clinic for a routine health check-up, and asked them to fill out a self-report questionnaire. Prevalence and overlap rate of GERD defined as heartburn and/or acid regurgitation at least weekly, FD and IBS based on Rome III criteria, and HR-QOL by SF-8 were examined. RESULTS: Of the 2680 eligible subjects, 207 (7.7%) were diagnosed as having GERD, 269 (10.0%) as FD, and 381 (14.2%) as IBS. Overlaps were found in 46.9% in GERD, 47.6% in FD, and 34.4% in IBS. Prevalence of overlaps in subjects with IBS was significantly lower compared with those among GERD or FD. Sufferers from GERD, FD, or IBS reported significantly poorer HR-QOL across all domains compared with controls. Overlaps significantly worsened HR-QOL in most domains except in the 'role emotional' domain. HR-QOL was particularly poor in the physical component summary for overlapping GERD and in the mental component summary for overlapping IBS. CONCLUSION: Overlaps among GERD, FD and IBS were common and worsened HR-QOL in Japanese general population. SN - 1440-1746 UR - https://www.unboundmedicine.com/medline/citation/20594232/Prevalence_of_overlaps_between_GERD_FD_and_IBS_and_impact_on_health_related_quality_of_life_ L2 - https://doi.org/10.1111/j.1440-1746.2010.06249.x DB - PRIME DP - Unbound Medicine ER -