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Long term follow-up of dogs diagnosed with leishmaniosis (clinical stage II) and treated with meglumine antimoniate and allopurinol.
Vet J. 2011 Jun; 188(3):346-51.VJ

Abstract

Twenty-three dogs with a diagnosis of leishmaniosis (clinical stage II) were treated with meglumine antimoniate and allopurinol and were followed up for 2-9 years. The treatment showed efficacy and the clinical condition of the dogs improved markedly in the first 3 months of treatment. Anti-Leishmania antibody titres declined slowly although most dogs remained seropositive 1 year after beginning treatment. Inter-individual variability in the evolution of the titres was very high. The dogs presented with three types of complications during the follow-up period. (1) Three dogs experienced relapses characterized by clinical signs, high anti-Leishmania titres and high parasitaemia. (2) Eight dogs presented immune-mediated lesions, such as uveitis, arthritis and cutaneous vasculitis; in all of these cases, the dogs had high titres of anti-Leishmania antibodies at diagnosis and during follow-up. (3) Three dogs presented xanthine urolithiasis most likely due to the allopurinol treatment. In one case the xanthine uroliths led to hydronephrosis and nephrectomy. The study demonstrated a long survival for dogs with leishmaniosis treated with the combination of meglumine antimoniate and allopurinol. Clinicians should pay special attention to the appearance of immune-mediated lesions, especially in dogs with sustained high antibody titres, and to urolithiasis.

Authors+Show Affiliations

Department of Animal Medicine and Surgery and Veterinary Teaching Hospital, Universitat Autònoma de Barcelona, 08193 Bellaterra, Barcelona, Spain.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

20594876

Citation

Torres, Marta, et al. "Long Term Follow-up of Dogs Diagnosed With Leishmaniosis (clinical Stage II) and Treated With Meglumine Antimoniate and Allopurinol." Veterinary Journal (London, England : 1997), vol. 188, no. 3, 2011, pp. 346-51.
Torres M, Bardagí M, Roura X, et al. Long term follow-up of dogs diagnosed with leishmaniosis (clinical stage II) and treated with meglumine antimoniate and allopurinol. Vet J. 2011;188(3):346-51.
Torres, M., Bardagí, M., Roura, X., Zanna, G., Ravera, I., & Ferrer, L. (2011). Long term follow-up of dogs diagnosed with leishmaniosis (clinical stage II) and treated with meglumine antimoniate and allopurinol. Veterinary Journal (London, England : 1997), 188(3), 346-51. https://doi.org/10.1016/j.tvjl.2010.05.025
Torres M, et al. Long Term Follow-up of Dogs Diagnosed With Leishmaniosis (clinical Stage II) and Treated With Meglumine Antimoniate and Allopurinol. Vet J. 2011;188(3):346-51. PubMed PMID: 20594876.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Long term follow-up of dogs diagnosed with leishmaniosis (clinical stage II) and treated with meglumine antimoniate and allopurinol. AU - Torres,Marta, AU - Bardagí,Mar, AU - Roura,Xavier, AU - Zanna,Giordana, AU - Ravera,Iván, AU - Ferrer,Lluís, Y1 - 2010/07/01/ PY - 2010/02/16/received PY - 2010/04/25/revised PY - 2010/05/23/accepted PY - 2010/7/3/entrez PY - 2010/7/3/pubmed PY - 2011/8/10/medline SP - 346 EP - 51 JF - Veterinary journal (London, England : 1997) JO - Vet J VL - 188 IS - 3 N2 - Twenty-three dogs with a diagnosis of leishmaniosis (clinical stage II) were treated with meglumine antimoniate and allopurinol and were followed up for 2-9 years. The treatment showed efficacy and the clinical condition of the dogs improved markedly in the first 3 months of treatment. Anti-Leishmania antibody titres declined slowly although most dogs remained seropositive 1 year after beginning treatment. Inter-individual variability in the evolution of the titres was very high. The dogs presented with three types of complications during the follow-up period. (1) Three dogs experienced relapses characterized by clinical signs, high anti-Leishmania titres and high parasitaemia. (2) Eight dogs presented immune-mediated lesions, such as uveitis, arthritis and cutaneous vasculitis; in all of these cases, the dogs had high titres of anti-Leishmania antibodies at diagnosis and during follow-up. (3) Three dogs presented xanthine urolithiasis most likely due to the allopurinol treatment. In one case the xanthine uroliths led to hydronephrosis and nephrectomy. The study demonstrated a long survival for dogs with leishmaniosis treated with the combination of meglumine antimoniate and allopurinol. Clinicians should pay special attention to the appearance of immune-mediated lesions, especially in dogs with sustained high antibody titres, and to urolithiasis. SN - 1532-2971 UR - https://www.unboundmedicine.com/medline/citation/20594876/Long_term_follow_up_of_dogs_diagnosed_with_leishmaniosis__clinical_stage_II__and_treated_with_meglumine_antimoniate_and_allopurinol_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1090-0233(10)00188-7 DB - PRIME DP - Unbound Medicine ER -