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Green tea supplementation affects body weight, lipids, and lipid peroxidation in obese subjects with metabolic syndrome.
J Am Coll Nutr 2010; 29(1):31-40JA

Abstract

OBJECTIVE

To compare the effects of supplementation of green tea beverage or green tea extracts with controls on body weight, glucose and lipid profile, biomarkers of oxidative stress, and safety parameters in obese subjects with metabolic syndrome.

DESIGN

Randomized, controlled prospective trial.

SETTING

General Clinical Research Center (GCRC) at University of Oklahoma Health Sciences Center (OUHSC).

SUBJECTS

Thirty-five subjects with obesity and metabolic syndrome were recruited in age- and gender-matched trios and were randomly assigned to the control (4 cups water/d), green tea (4 cups/d), or green tea extract (2 capsules and 4 cups water/d) group for 8 weeks. The tea and extract groups had similar dosing of epiogallocatechin-3-gallate (EGCG), the active compound in green tea.

METHODS

Anthropometrics, blood pressure, fasting glucose and lipids, nuclear magnetic resonance (NMR)-based lipid particle size, safety parameters, biomarkers of oxidative stress (oxidized low-density lipoprotein [LDL], myeloperoxidase [MPO], malondialdehyde and hydroxynonenals [MDA and HNE]), and free catechins were analyzed at screen and at 4 and 8 weeks of the study.

RESULTS

Pairwise comparisons showed green tea beverage and green tea extracts caused a significant decrease in body weight and body mass index (BMI) versus controls at 8 weeks (-2.5 +/- 0.7 kg, p < 0.01, and -1.9 +/- 0.6, p < 0.05, respectively). Green tea beverage showed a decreasing trend in LDL-cholesterol and LDL/high-density lipoprotein (HDL) versus controls (p < 0.1). Green tea beverage also significantly decreased MDA and HNE (-0.39 +/- 0.06 microM, p < 0.0001) versus controls. Plasma free catechins were detectable in both beverage and extract groups versus controls at screen and at 8 weeks, indicating compliance and bioavailability of green tea catechins.

CONCLUSIONS

Green tea beverage consumption (4 cups/d) or extract supplementation (2 capsules/d) for 8 weeks significantly decreased body weight and BMI. Green tea beverage further lowered lipid peroxidation versus age- and gender-matched controls, suggesting the role of green tea flavonoids in improving features of metabolic syndrome in obese patients.

Authors+Show Affiliations

Nutritional Sciences, Human Environmental Sciences, Oklahoma State University, Stillwater, Oklahoma, USA. arpita.basu@okstate.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20595643

Citation

Basu, Arpita, et al. "Green Tea Supplementation Affects Body Weight, Lipids, and Lipid Peroxidation in Obese Subjects With Metabolic Syndrome." Journal of the American College of Nutrition, vol. 29, no. 1, 2010, pp. 31-40.
Basu A, Sanchez K, Leyva MJ, et al. Green tea supplementation affects body weight, lipids, and lipid peroxidation in obese subjects with metabolic syndrome. J Am Coll Nutr. 2010;29(1):31-40.
Basu, A., Sanchez, K., Leyva, M. J., Wu, M., Betts, N. M., Aston, C. E., & Lyons, T. J. (2010). Green tea supplementation affects body weight, lipids, and lipid peroxidation in obese subjects with metabolic syndrome. Journal of the American College of Nutrition, 29(1), pp. 31-40.
Basu A, et al. Green Tea Supplementation Affects Body Weight, Lipids, and Lipid Peroxidation in Obese Subjects With Metabolic Syndrome. J Am Coll Nutr. 2010;29(1):31-40. PubMed PMID: 20595643.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Green tea supplementation affects body weight, lipids, and lipid peroxidation in obese subjects with metabolic syndrome. AU - Basu,Arpita, AU - Sanchez,Karah, AU - Leyva,Misti J, AU - Wu,Mingyuan, AU - Betts,Nancy M, AU - Aston,Christopher E, AU - Lyons,Timothy J, PY - 2010/7/3/entrez PY - 2010/7/3/pubmed PY - 2010/12/14/medline SP - 31 EP - 40 JF - Journal of the American College of Nutrition JO - J Am Coll Nutr VL - 29 IS - 1 N2 - OBJECTIVE: To compare the effects of supplementation of green tea beverage or green tea extracts with controls on body weight, glucose and lipid profile, biomarkers of oxidative stress, and safety parameters in obese subjects with metabolic syndrome. DESIGN: Randomized, controlled prospective trial. SETTING: General Clinical Research Center (GCRC) at University of Oklahoma Health Sciences Center (OUHSC). SUBJECTS: Thirty-five subjects with obesity and metabolic syndrome were recruited in age- and gender-matched trios and were randomly assigned to the control (4 cups water/d), green tea (4 cups/d), or green tea extract (2 capsules and 4 cups water/d) group for 8 weeks. The tea and extract groups had similar dosing of epiogallocatechin-3-gallate (EGCG), the active compound in green tea. METHODS: Anthropometrics, blood pressure, fasting glucose and lipids, nuclear magnetic resonance (NMR)-based lipid particle size, safety parameters, biomarkers of oxidative stress (oxidized low-density lipoprotein [LDL], myeloperoxidase [MPO], malondialdehyde and hydroxynonenals [MDA and HNE]), and free catechins were analyzed at screen and at 4 and 8 weeks of the study. RESULTS: Pairwise comparisons showed green tea beverage and green tea extracts caused a significant decrease in body weight and body mass index (BMI) versus controls at 8 weeks (-2.5 +/- 0.7 kg, p < 0.01, and -1.9 +/- 0.6, p < 0.05, respectively). Green tea beverage showed a decreasing trend in LDL-cholesterol and LDL/high-density lipoprotein (HDL) versus controls (p < 0.1). Green tea beverage also significantly decreased MDA and HNE (-0.39 +/- 0.06 microM, p < 0.0001) versus controls. Plasma free catechins were detectable in both beverage and extract groups versus controls at screen and at 8 weeks, indicating compliance and bioavailability of green tea catechins. CONCLUSIONS: Green tea beverage consumption (4 cups/d) or extract supplementation (2 capsules/d) for 8 weeks significantly decreased body weight and BMI. Green tea beverage further lowered lipid peroxidation versus age- and gender-matched controls, suggesting the role of green tea flavonoids in improving features of metabolic syndrome in obese patients. SN - 1541-1087 UR - https://www.unboundmedicine.com/medline/citation/20595643/Green_tea_supplementation_affects_body_weight_lipids_and_lipid_peroxidation_in_obese_subjects_with_metabolic_syndrome_ L2 - http://www.tandfonline.com/doi/full/10.1080/07315724.2010.10719814 DB - PRIME DP - Unbound Medicine ER -