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Evidence for VAV2 and ZNF433 as susceptibility genes for multiple sclerosis.
J Neuroimmunol 2010; 227(1-2):162-6JN

Abstract

In a genome wide association study consisting of 592 German multiple sclerosis (MS) patients and 825 controls we were able to replicate the association of the HLA region with MS independently of previous case control studies. No SNPs outside the HLA region reached a genome wide level of significance. Nevertheless, we found suggestive evidence for an association of MS with variants in two new genes, the VAV2 gene and the gene for ZNF433.

Authors+Show Affiliations

Max Planck Institute of Psychiatry, 80804 Munich, Germany.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20598377

Citation

Nischwitz, Sandra, et al. "Evidence for VAV2 and ZNF433 as Susceptibility Genes for Multiple Sclerosis." Journal of Neuroimmunology, vol. 227, no. 1-2, 2010, pp. 162-6.
Nischwitz S, Cepok S, Kroner A, et al. Evidence for VAV2 and ZNF433 as susceptibility genes for multiple sclerosis. J Neuroimmunol. 2010;227(1-2):162-6.
Nischwitz, S., Cepok, S., Kroner, A., Wolf, C., Knop, M., Müller-Sarnowski, F., ... Weber, F. (2010). Evidence for VAV2 and ZNF433 as susceptibility genes for multiple sclerosis. Journal of Neuroimmunology, 227(1-2), pp. 162-6. doi:10.1016/j.jneuroim.2010.06.003.
Nischwitz S, et al. Evidence for VAV2 and ZNF433 as Susceptibility Genes for Multiple Sclerosis. J Neuroimmunol. 2010 Oct 8;227(1-2):162-6. PubMed PMID: 20598377.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evidence for VAV2 and ZNF433 as susceptibility genes for multiple sclerosis. AU - Nischwitz,Sandra, AU - Cepok,Sabine, AU - Kroner,Antje, AU - Wolf,Christiane, AU - Knop,Matthias, AU - Müller-Sarnowski,Felix, AU - Pfister,Hildegard, AU - Roeske,Darina, AU - Rieckmann,Peter, AU - Hemmer,Bernhard, AU - Ising,Marcus, AU - Uhr,Manfred, AU - Bettecken,Thomas, AU - Holsboer,Florian, AU - Müller-Myhsok,Bertram, AU - Weber,Frank, Y1 - 2010/07/02/ PY - 2009/07/24/received PY - 2010/06/01/revised PY - 2010/06/02/accepted PY - 2010/7/6/entrez PY - 2010/7/6/pubmed PY - 2010/10/20/medline SP - 162 EP - 6 JF - Journal of neuroimmunology JO - J. Neuroimmunol. VL - 227 IS - 1-2 N2 - In a genome wide association study consisting of 592 German multiple sclerosis (MS) patients and 825 controls we were able to replicate the association of the HLA region with MS independently of previous case control studies. No SNPs outside the HLA region reached a genome wide level of significance. Nevertheless, we found suggestive evidence for an association of MS with variants in two new genes, the VAV2 gene and the gene for ZNF433. SN - 1872-8421 UR - https://www.unboundmedicine.com/medline/citation/20598377/Evidence_for_VAV2_and_ZNF433_as_susceptibility_genes_for_multiple_sclerosis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0165-5728(10)00258-4 DB - PRIME DP - Unbound Medicine ER -