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Modulation of glutathione-related antioxidant defense system of fish chronically treated by the fungicide propiconazole.
Comp Biochem Physiol C Toxicol Pharmacol. 2010 Sep; 152(3):392-8.CB

Abstract

Recently, residual fungicides are generally recognized as relevant sources of aquatic environmental pollutants. However, the toxicological effects of these contaminants have not been adequately researched. In this study, the chronic effect of PCZ, a triazole-containing fungicide commonly present in aquatic environment, on GSH-related antioxidant system and oxidative stress indices of rainbow trout (Oncorhynchus mykiss) were investigated. Fish were exposed at sub-lethal concentrations of PCZ (0.2, 50 and 500 microg/L) for 7, 20 and 30 days. GSH levels and GSH-related enzyme activities, including GPx, GR and GST, were quantified in three tissues-liver, gill and muscle. The levels of LPO and CP were also measured as makers of oxidative damage. In addition, the correlations of the measured parameters in various tissues were evaluated by using PCA. The results of this study indicate that chronic exposure of PCZ has resulted in different responses in various tissues and the gill was the most sensitive tissue; however, before these parameters are used as potential biomarkers for monitoring residual fungicides in aquatic environment, more detailed experiments in laboratory need to be performed in the future.

Authors+Show Affiliations

University of South Bohemia in Ceske Budejovice, Faculty of Fisheries and Protection of Waters, Research Institute of Fish Culture and Hydrobiology, Zatisi 728/II, 389 25 Vodnany, Czech Republic. zhihuali06@yahoo.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20601116

Citation

Li, Zhi-Hua, et al. "Modulation of Glutathione-related Antioxidant Defense System of Fish Chronically Treated By the Fungicide Propiconazole." Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP, vol. 152, no. 3, 2010, pp. 392-8.
Li ZH, Zlabek V, Grabic R, et al. Modulation of glutathione-related antioxidant defense system of fish chronically treated by the fungicide propiconazole. Comp Biochem Physiol C Toxicol Pharmacol. 2010;152(3):392-8.
Li, Z. H., Zlabek, V., Grabic, R., Li, P., & Randak, T. (2010). Modulation of glutathione-related antioxidant defense system of fish chronically treated by the fungicide propiconazole. Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP, 152(3), 392-8. https://doi.org/10.1016/j.cbpc.2010.06.006
Li ZH, et al. Modulation of Glutathione-related Antioxidant Defense System of Fish Chronically Treated By the Fungicide Propiconazole. Comp Biochem Physiol C Toxicol Pharmacol. 2010;152(3):392-8. PubMed PMID: 20601116.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Modulation of glutathione-related antioxidant defense system of fish chronically treated by the fungicide propiconazole. AU - Li,Zhi-Hua, AU - Zlabek,Vladimir, AU - Grabic,Roman, AU - Li,Ping, AU - Randak,Tomas, Y1 - 2010/06/25/ PY - 2010/04/29/received PY - 2010/06/16/revised PY - 2010/06/17/accepted PY - 2010/7/6/entrez PY - 2010/7/6/pubmed PY - 2010/9/18/medline SP - 392 EP - 8 JF - Comparative biochemistry and physiology. Toxicology & pharmacology : CBP JO - Comp Biochem Physiol C Toxicol Pharmacol VL - 152 IS - 3 N2 - Recently, residual fungicides are generally recognized as relevant sources of aquatic environmental pollutants. However, the toxicological effects of these contaminants have not been adequately researched. In this study, the chronic effect of PCZ, a triazole-containing fungicide commonly present in aquatic environment, on GSH-related antioxidant system and oxidative stress indices of rainbow trout (Oncorhynchus mykiss) were investigated. Fish were exposed at sub-lethal concentrations of PCZ (0.2, 50 and 500 microg/L) for 7, 20 and 30 days. GSH levels and GSH-related enzyme activities, including GPx, GR and GST, were quantified in three tissues-liver, gill and muscle. The levels of LPO and CP were also measured as makers of oxidative damage. In addition, the correlations of the measured parameters in various tissues were evaluated by using PCA. The results of this study indicate that chronic exposure of PCZ has resulted in different responses in various tissues and the gill was the most sensitive tissue; however, before these parameters are used as potential biomarkers for monitoring residual fungicides in aquatic environment, more detailed experiments in laboratory need to be performed in the future. SN - 1532-0456 UR - https://www.unboundmedicine.com/medline/citation/20601116/Modulation_of_glutathione_related_antioxidant_defense_system_of_fish_chronically_treated_by_the_fungicide_propiconazole_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1532-0456(10)00117-1 DB - PRIME DP - Unbound Medicine ER -