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Vitamin D and Alzheimer's disease: is there a link?

Abstract

OBJECTIVE

To review the research on a possible link between Alzheimer's disease (AD) and vitamin D deficiency.

DATA SOURCE

MEDLINE/PUBMED (January 1950-January 2010) and ISI Web of Science searches (January 1900-January 2010) were conducted using the key words vitamin D, Alzheimer disease, and dementia to identify pertinent studies. The Cochrane Library was searched to identify review articles along with clinicaltrials.gov to identify unpublished research.

STUDY SELECTION AND DATA EXTRACTION

Vitamin D and (Alzheimer* disease or dementia) was entered into each database. Manual review of the search results identified trials that discussed an association between AD or dementia and vitamin D. Manual bibliography searches were performed to identify other pertinent articles.

DATA SYNTHESIS

Vitamin D deficiency is a widespread problem among the elderly and has been associated with multiple disease states. Vitamin D deficiency has recently been linked to dementia, particularly AD, through several mechanisms. Current clinical trials discuss a possible link between low vitamin D levels and low cognitive test scores in AD patients.

CONCLUSION

The current observational studies seem to identify a link between vitamin D and dementia, particularly AD. Before this evidence can be used to make a recommendation for routine supplementation in elderly patients to prevent AD, more prospective trials with a longer follow-up period are needed to show a causality relationship.

Authors+Show Affiliations

Midwestern University College of Pharmacy-Glendale, Glendale, Arizona 85308, USA. epogge@midwestern.edu

Source

MeSH

Adolescent
Adult
Aged
Aged, 80 and over
Alzheimer Disease
Child
Child, Preschool
Clinical Trials as Topic
Female
Humans
Infant
Male
Middle Aged
Nutritional Requirements
Vitamin D
Vitamin D Deficiency
Vitamins
Young Adult

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

20601349

Citation

Pogge, Elizabeth. "Vitamin D and Alzheimer's Disease: Is There a Link?" The Consultant Pharmacist : the Journal of the American Society of Consultant Pharmacists, vol. 25, no. 7, 2010, pp. 440-50.
Pogge E. Vitamin D and Alzheimer's disease: is there a link? Consult Pharm. 2010;25(7):440-50.
Pogge, E. (2010). Vitamin D and Alzheimer's disease: is there a link? The Consultant Pharmacist : the Journal of the American Society of Consultant Pharmacists, 25(7), pp. 440-50. doi:10.4140/TCP.n.2010.440.
Pogge E. Vitamin D and Alzheimer's Disease: Is There a Link. Consult Pharm. 2010;25(7):440-50. PubMed PMID: 20601349.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vitamin D and Alzheimer's disease: is there a link? A1 - Pogge,Elizabeth, PY - 2010/7/6/entrez PY - 2010/7/6/pubmed PY - 2010/8/27/medline SP - 440 EP - 50 JF - The Consultant pharmacist : the journal of the American Society of Consultant Pharmacists JO - Consult Pharm VL - 25 IS - 7 N2 - OBJECTIVE: To review the research on a possible link between Alzheimer's disease (AD) and vitamin D deficiency. DATA SOURCE: MEDLINE/PUBMED (January 1950-January 2010) and ISI Web of Science searches (January 1900-January 2010) were conducted using the key words vitamin D, Alzheimer disease, and dementia to identify pertinent studies. The Cochrane Library was searched to identify review articles along with clinicaltrials.gov to identify unpublished research. STUDY SELECTION AND DATA EXTRACTION: Vitamin D and (Alzheimer* disease or dementia) was entered into each database. Manual review of the search results identified trials that discussed an association between AD or dementia and vitamin D. Manual bibliography searches were performed to identify other pertinent articles. DATA SYNTHESIS: Vitamin D deficiency is a widespread problem among the elderly and has been associated with multiple disease states. Vitamin D deficiency has recently been linked to dementia, particularly AD, through several mechanisms. Current clinical trials discuss a possible link between low vitamin D levels and low cognitive test scores in AD patients. CONCLUSION: The current observational studies seem to identify a link between vitamin D and dementia, particularly AD. Before this evidence can be used to make a recommendation for routine supplementation in elderly patients to prevent AD, more prospective trials with a longer follow-up period are needed to show a causality relationship. SN - 0888-5109 UR - https://www.unboundmedicine.com/medline/citation/20601349/Vitamin_D_and_Alzheimer's_disease:_is_there_a_link L2 - https://medlineplus.gov/vitamind.html DB - PRIME DP - Unbound Medicine ER -