Abstract
OBJECTIVE
To review the research on a possible link between Alzheimer's disease (AD) and vitamin D deficiency.
DATA SOURCE
MEDLINE/PUBMED (January 1950-January 2010) and ISI Web of Science searches (January 1900-January 2010) were conducted using the key words vitamin D, Alzheimer disease, and dementia to identify pertinent studies. The Cochrane Library was searched to identify review articles along with clinicaltrials.gov to identify unpublished research.
STUDY SELECTION AND DATA EXTRACTION
Vitamin D and (Alzheimer* disease or dementia) was entered into each database. Manual review of the search results identified trials that discussed an association between AD or dementia and vitamin D. Manual bibliography searches were performed to identify other pertinent articles.
DATA SYNTHESIS
Vitamin D deficiency is a widespread problem among the elderly and has been associated with multiple disease states. Vitamin D deficiency has recently been linked to dementia, particularly AD, through several mechanisms. Current clinical trials discuss a possible link between low vitamin D levels and low cognitive test scores in AD patients.
CONCLUSION
The current observational studies seem to identify a link between vitamin D and dementia, particularly AD. Before this evidence can be used to make a recommendation for routine supplementation in elderly patients to prevent AD, more prospective trials with a longer follow-up period are needed to show a causality relationship.
TY - JOUR
T1 - Vitamin D and Alzheimer's disease: is there a link?
A1 - Pogge,Elizabeth,
PY - 2010/7/6/entrez
PY - 2010/7/6/pubmed
PY - 2010/8/27/medline
SP - 440
EP - 50
JF - The Consultant pharmacist : the journal of the American Society of Consultant Pharmacists
JO - Consult Pharm
VL - 25
IS - 7
N2 - OBJECTIVE: To review the research on a possible link between Alzheimer's disease (AD) and vitamin D deficiency. DATA SOURCE: MEDLINE/PUBMED (January 1950-January 2010) and ISI Web of Science searches (January 1900-January 2010) were conducted using the key words vitamin D, Alzheimer disease, and dementia to identify pertinent studies. The Cochrane Library was searched to identify review articles along with clinicaltrials.gov to identify unpublished research. STUDY SELECTION AND DATA EXTRACTION: Vitamin D and (Alzheimer* disease or dementia) was entered into each database. Manual review of the search results identified trials that discussed an association between AD or dementia and vitamin D. Manual bibliography searches were performed to identify other pertinent articles. DATA SYNTHESIS: Vitamin D deficiency is a widespread problem among the elderly and has been associated with multiple disease states. Vitamin D deficiency has recently been linked to dementia, particularly AD, through several mechanisms. Current clinical trials discuss a possible link between low vitamin D levels and low cognitive test scores in AD patients. CONCLUSION: The current observational studies seem to identify a link between vitamin D and dementia, particularly AD. Before this evidence can be used to make a recommendation for routine supplementation in elderly patients to prevent AD, more prospective trials with a longer follow-up period are needed to show a causality relationship.
SN - 0888-5109
UR - https://www.unboundmedicine.com/medline/citation/20601349/Vitamin_D_and_Alzheimer's_disease:_is_there_a_link
L2 - https://www.ingentaconnect.com/openurl?genre=article&issn=0888-5109&volume=25&issue=7&spage=440&aulast=Pogge
DB - PRIME
DP - Unbound Medicine
ER -
