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The azoospermia factor locus-c region was found to be related to Klinefelter syndrome in Turkish patients.
Genet Mol Res. 2010 Jun 29; 9(2):1229-33.GM

Abstract

We looked for a possible association between Klinefelter syndrome (KFS) and microdeletions in the Y chromosome in Turkish KFS patients. We examined the frequency of KFS in male patients with proven non-obstructive azoospermia and the types of Y chromosome microdeletions in these KFS patients. Fifty azoospermic patients and 50 fertile men were included in this study. KFS was found in 14 azoospermic patients. Y chromosome microdeletions were found in eight KFS patients. Azoospermia factor locus c (AZFc) was the most commonly deleted interval in KFS patients. All KFS patients had elevated plasma follicle-stimulating hormone and luteinizing hormone concentrations, but they had normal plasma testosterone concentrations. Testis biopsy of five samples with Y microdeletions revealed Sertoli cell-only syndrome. No Y microdeletions were found in the fertile group. We concluded that there could be an association between the AZFc region and KFS. Screening for this should be part of diagnostic work-up, particularly in those considering assisted reproduction.

Authors+Show Affiliations

Department of Urology, Elaziğ Research and Training Hospital, Turkey. ceylacavit@yahoo.comNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

20603808

Citation

Ceylan, C, et al. "The Azoospermia Factor Locus-c Region Was Found to Be Related to Klinefelter Syndrome in Turkish Patients." Genetics and Molecular Research : GMR, vol. 9, no. 2, 2010, pp. 1229-33.
Ceylan C, Ceylan GG, Serel TA. The azoospermia factor locus-c region was found to be related to Klinefelter syndrome in Turkish patients. Genet Mol Res. 2010;9(2):1229-33.
Ceylan, C., Ceylan, G. G., & Serel, T. A. (2010). The azoospermia factor locus-c region was found to be related to Klinefelter syndrome in Turkish patients. Genetics and Molecular Research : GMR, 9(2), 1229-33. https://doi.org/10.4238/vol9-2gmr826
Ceylan C, Ceylan GG, Serel TA. The Azoospermia Factor Locus-c Region Was Found to Be Related to Klinefelter Syndrome in Turkish Patients. Genet Mol Res. 2010 Jun 29;9(2):1229-33. PubMed PMID: 20603808.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The azoospermia factor locus-c region was found to be related to Klinefelter syndrome in Turkish patients. AU - Ceylan,C, AU - Ceylan,G G, AU - Serel,T A, Y1 - 2010/06/29/ PY - 2010/7/7/entrez PY - 2010/7/7/pubmed PY - 2010/11/6/medline SP - 1229 EP - 33 JF - Genetics and molecular research : GMR JO - Genet. Mol. Res. VL - 9 IS - 2 N2 - We looked for a possible association between Klinefelter syndrome (KFS) and microdeletions in the Y chromosome in Turkish KFS patients. We examined the frequency of KFS in male patients with proven non-obstructive azoospermia and the types of Y chromosome microdeletions in these KFS patients. Fifty azoospermic patients and 50 fertile men were included in this study. KFS was found in 14 azoospermic patients. Y chromosome microdeletions were found in eight KFS patients. Azoospermia factor locus c (AZFc) was the most commonly deleted interval in KFS patients. All KFS patients had elevated plasma follicle-stimulating hormone and luteinizing hormone concentrations, but they had normal plasma testosterone concentrations. Testis biopsy of five samples with Y microdeletions revealed Sertoli cell-only syndrome. No Y microdeletions were found in the fertile group. We concluded that there could be an association between the AZFc region and KFS. Screening for this should be part of diagnostic work-up, particularly in those considering assisted reproduction. SN - 1676-5680 UR - https://www.unboundmedicine.com/medline/citation/20603808/The_azoospermia_factor_locus_c_region_was_found_to_be_related_to_Klinefelter_syndrome_in_Turkish_patients_ L2 - http://www.funpecrp.com.br/gmr/year2010/vol9-2/pdf/gmr826.pdf DB - PRIME DP - Unbound Medicine ER -