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Further studies on effect of storage at high temperatures upon allergenic potency of dried BCG vaccine.
Bull World Health Organ 1959; 20(6):1165-74BW

Abstract

The authors describe experiments which were carried out to determine the effect on the allergenic potency of dried glutamate BCG vaccine and dried sucrose BCG vaccine of storage at high temperatures.The two vaccines in question were inoculated into school-children after storage for one month at the following temperatures: 5 degrees C, 30 degrees C, 38.5 degrees C and 50 degrees C. The tuberculin reactions of these children were examined 4 and 12 months after the vaccination, both Japanese Old Tuberculin (OT) and Danish purified tuberculin (PPD) being used in the testing.After storage for one month at temperatures exceeding 30 degrees C, the allergenic potency of the dried glutamate vaccine was consistently higher than that of the dried sucrose vaccine. The decrease in potency of the dried sucrose vaccine was evident after storage at 30 degrees C for one month, whereas the dried glutamate vaccine showed a significant decrease in potency only after storage at 50 degrees C for the same period. This tendency was observed in the tuberculin testing up to 12 months after vaccination, and, furthermore, was apparent whether the post-vaccination tuberculin allergy was estimated in terms of erythema with OT or in terms of induration with PPD.

Authors

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Pub Type(s)

Journal Article

Language

eng

PubMed ID

20604052

Citation

Obayashi, Y, et al. "Further Studies On Effect of Storage at High Temperatures Upon Allergenic Potency of Dried BCG Vaccine." Bulletin of the World Health Organization, vol. 20, no. 6, 1959, pp. 1165-74.
Obayashi Y, Cho C, Sawada T, et al. Further studies on effect of storage at high temperatures upon allergenic potency of dried BCG vaccine. Bull World Health Organ. 1959;20(6):1165-74.
Obayashi, Y., Cho, C., Sawada, T., Kuchiki, G., Ota, S., & Kawasaki, J. (1959). Further studies on effect of storage at high temperatures upon allergenic potency of dried BCG vaccine. Bulletin of the World Health Organization, 20(6), pp. 1165-74.
Obayashi Y, et al. Further Studies On Effect of Storage at High Temperatures Upon Allergenic Potency of Dried BCG Vaccine. Bull World Health Organ. 1959;20(6):1165-74. PubMed PMID: 20604052.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Further studies on effect of storage at high temperatures upon allergenic potency of dried BCG vaccine. AU - Obayashi,Y, AU - Cho,C, AU - Sawada,T, AU - Kuchiki,G, AU - Ota,S, AU - Kawasaki,J, PY - 2010/7/7/entrez PY - 1959/1/1/pubmed PY - 1959/1/1/medline SP - 1165 EP - 74 JF - Bulletin of the World Health Organization JO - Bull. World Health Organ. VL - 20 IS - 6 N2 - The authors describe experiments which were carried out to determine the effect on the allergenic potency of dried glutamate BCG vaccine and dried sucrose BCG vaccine of storage at high temperatures.The two vaccines in question were inoculated into school-children after storage for one month at the following temperatures: 5 degrees C, 30 degrees C, 38.5 degrees C and 50 degrees C. The tuberculin reactions of these children were examined 4 and 12 months after the vaccination, both Japanese Old Tuberculin (OT) and Danish purified tuberculin (PPD) being used in the testing.After storage for one month at temperatures exceeding 30 degrees C, the allergenic potency of the dried glutamate vaccine was consistently higher than that of the dried sucrose vaccine. The decrease in potency of the dried sucrose vaccine was evident after storage at 30 degrees C for one month, whereas the dried glutamate vaccine showed a significant decrease in potency only after storage at 50 degrees C for the same period. This tendency was observed in the tuberculin testing up to 12 months after vaccination, and, furthermore, was apparent whether the post-vaccination tuberculin allergy was estimated in terms of erythema with OT or in terms of induration with PPD. SN - 0042-9686 UR - https://www.unboundmedicine.com/medline/citation/20604052/Further_studies_on_effect_of_storage_at_high_temperatures_upon_allergenic_potency_of_dried_BCG_vaccine_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20604052/ DB - PRIME DP - Unbound Medicine ER -