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Association of cigarette smoking with diabetic retinopathy.
Diabetes Care 1991; 14(2):119-26DC

Abstract

OBJECTIVE

To determine whether cigarette smoking is associated with the incidence and progression of diabetic retinopathy.

RESEARCH DESIGN AND METHODS

Younger-onset diabetic subjects who had been diagnosed at less than 30 yr of age and taking insulin (n = 1210) and a random sample of older-onset diabetic subjects diagnosed at greater than or equal to 30 yr of age (n = 1780) were selected. Baseline examinations were conducted on 996 younger- and 1370 older-onset subjects. Incidence of retinopathy was based on 138 younger-onset and 154 older-onset insulin-taking subjects and 321 older-onset non-insulin-taking subjects who were free of retinopathy at baseline. Progression of retinopathy was based on 530 younger-onset and 418 older-onset insulin-taking subjects and 486 older-onset non-insulin-taking subjects with less than proliferative diabetic retinopathy at baseline.

RESULTS

Baseline smoking history was categorized by status (nonsmoker, ex-smoker, current smoker) and pack-years smoked while diabetic. Retinopathy was documented by stereoscopic fundus photography. In univariate analyses, the only significant association was between pack-years and progression to proliferative diabetic retinopathy in older-onset insulin-taking subjects (P less than 0.01). After controlling for known risk factors for the incidence and progression of retinopathy, pack-years smoked was borderline significant (P = 0.052) in predicting incidence of retinopathy in younger-onset subjects. Smoking was not associated with incidence in older-onset subjects or with progression or progression to proliferative diabetic retinopathy in any of the groups.

CONCLUSIONS

Smoking is not likely to be an important risk factor for diabetic retinopathy.

Authors+Show Affiliations

Department of Ophthalmology, University of Wisconsin Medical School, Madison.No affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

2060413

Citation

Moss, S E., et al. "Association of Cigarette Smoking With Diabetic Retinopathy." Diabetes Care, vol. 14, no. 2, 1991, pp. 119-26.
Moss SE, Klein R, Klein BE. Association of cigarette smoking with diabetic retinopathy. Diabetes Care. 1991;14(2):119-26.
Moss, S. E., Klein, R., & Klein, B. E. (1991). Association of cigarette smoking with diabetic retinopathy. Diabetes Care, 14(2), pp. 119-26.
Moss SE, Klein R, Klein BE. Association of Cigarette Smoking With Diabetic Retinopathy. Diabetes Care. 1991;14(2):119-26. PubMed PMID: 2060413.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association of cigarette smoking with diabetic retinopathy. AU - Moss,S E, AU - Klein,R, AU - Klein,B E, PY - 1991/2/1/pubmed PY - 1991/2/1/medline PY - 1991/2/1/entrez SP - 119 EP - 26 JF - Diabetes care JO - Diabetes Care VL - 14 IS - 2 N2 - OBJECTIVE: To determine whether cigarette smoking is associated with the incidence and progression of diabetic retinopathy. RESEARCH DESIGN AND METHODS: Younger-onset diabetic subjects who had been diagnosed at less than 30 yr of age and taking insulin (n = 1210) and a random sample of older-onset diabetic subjects diagnosed at greater than or equal to 30 yr of age (n = 1780) were selected. Baseline examinations were conducted on 996 younger- and 1370 older-onset subjects. Incidence of retinopathy was based on 138 younger-onset and 154 older-onset insulin-taking subjects and 321 older-onset non-insulin-taking subjects who were free of retinopathy at baseline. Progression of retinopathy was based on 530 younger-onset and 418 older-onset insulin-taking subjects and 486 older-onset non-insulin-taking subjects with less than proliferative diabetic retinopathy at baseline. RESULTS: Baseline smoking history was categorized by status (nonsmoker, ex-smoker, current smoker) and pack-years smoked while diabetic. Retinopathy was documented by stereoscopic fundus photography. In univariate analyses, the only significant association was between pack-years and progression to proliferative diabetic retinopathy in older-onset insulin-taking subjects (P less than 0.01). After controlling for known risk factors for the incidence and progression of retinopathy, pack-years smoked was borderline significant (P = 0.052) in predicting incidence of retinopathy in younger-onset subjects. Smoking was not associated with incidence in older-onset subjects or with progression or progression to proliferative diabetic retinopathy in any of the groups. CONCLUSIONS: Smoking is not likely to be an important risk factor for diabetic retinopathy. SN - 0149-5992 UR - https://www.unboundmedicine.com/medline/citation/2060413/Association_of_cigarette_smoking_with_diabetic_retinopathy_ L2 - https://medlineplus.gov/diabeticeyeproblems.html DB - PRIME DP - Unbound Medicine ER -