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Anti-NMDA-receptor encephalitis: an adolescent with an ovarian teratoma.
J Pediatr Adolesc Gynecol. 2010 Oct; 23(5):e141-4.JP

Abstract

BACKGROUND

Anti-N-methyl-D-aspartate (NMDA) receptor encephalitis has been reported to be associated with ovarian teratomas. In many patients, surgical excision has resulted in improvement.

CASE

A previously healthy 14-year-old girl presented with confusion which later evolved into a comatose state. Imaging revealed an adnexal mass which was surgically removed and confirmed to be a mature teratoma. Her cerebral spinal fluid was positive for antibodies to NR1/NR2 heteromers of NMDA receptors.

COMMENTS

Cystic teratomas are one of the most common benign ovarian lesions in children and young women. While an association of ovarian teratomas and paraneoplastic encephalitis is published in the neurologic literature, this association needs to be clarified for the practicing gynecologist who may be asked to consult on these patients.

Authors+Show Affiliations

Division of General Obstetrics & Gynecology, Washington University School of Medicine, St. Louis Children's Hospital, Barnes Jewish Hospital, St. Louis, Missouri 63110, USA. sonnt@wudosis.wustl.eduNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

20605495

Citation

Sonn, Tammy S., and Diane F. Merritt. "Anti-NMDA-receptor Encephalitis: an Adolescent With an Ovarian Teratoma." Journal of Pediatric and Adolescent Gynecology, vol. 23, no. 5, 2010, pp. e141-4.
Sonn TS, Merritt DF. Anti-NMDA-receptor encephalitis: an adolescent with an ovarian teratoma. J Pediatr Adolesc Gynecol. 2010;23(5):e141-4.
Sonn, T. S., & Merritt, D. F. (2010). Anti-NMDA-receptor encephalitis: an adolescent with an ovarian teratoma. Journal of Pediatric and Adolescent Gynecology, 23(5), e141-4. https://doi.org/10.1016/j.jpag.2010.02.007
Sonn TS, Merritt DF. Anti-NMDA-receptor Encephalitis: an Adolescent With an Ovarian Teratoma. J Pediatr Adolesc Gynecol. 2010;23(5):e141-4. PubMed PMID: 20605495.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Anti-NMDA-receptor encephalitis: an adolescent with an ovarian teratoma. AU - Sonn,Tammy S, AU - Merritt,Diane F, PY - 2009/10/26/received PY - 2010/02/18/revised PY - 2010/02/23/accepted PY - 2010/7/8/entrez PY - 2010/7/8/pubmed PY - 2011/1/7/medline SP - e141 EP - 4 JF - Journal of pediatric and adolescent gynecology JO - J Pediatr Adolesc Gynecol VL - 23 IS - 5 N2 - BACKGROUND: Anti-N-methyl-D-aspartate (NMDA) receptor encephalitis has been reported to be associated with ovarian teratomas. In many patients, surgical excision has resulted in improvement. CASE: A previously healthy 14-year-old girl presented with confusion which later evolved into a comatose state. Imaging revealed an adnexal mass which was surgically removed and confirmed to be a mature teratoma. Her cerebral spinal fluid was positive for antibodies to NR1/NR2 heteromers of NMDA receptors. COMMENTS: Cystic teratomas are one of the most common benign ovarian lesions in children and young women. While an association of ovarian teratomas and paraneoplastic encephalitis is published in the neurologic literature, this association needs to be clarified for the practicing gynecologist who may be asked to consult on these patients. SN - 1873-4332 UR - https://www.unboundmedicine.com/medline/citation/20605495/Anti_NMDA_receptor_encephalitis:_an_adolescent_with_an_ovarian_teratoma_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1083-3188(10)00107-5 DB - PRIME DP - Unbound Medicine ER -