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Trans-8, cis-10+ cis-9, trans-11-conjugated linoleic acid mixture alters body composition in Syrian golden hamsters fed a hypercholesterolaemic diet.
Br J Nutr. 2010 Nov; 104(10):1443-9.BJ

Abstract

The effectiveness of conjugated linoleic acid (CLA) as a weight-loss nutraceutical continues to be debatable, suggesting that there may be value in exploring the physiological effects of the lesser-known isomers. The effects of the minor isomer, trans-8, cis-10 (t8, c10)-CLA, in the form of an equimolar mixture with the cis-9, trans-11 (c9, t11) isomer, on body weight and body composition, circulating glucose and lipid concentrations, and liver weights were studied in sixty male Syrian golden hamsters. Animals were randomised to receive for 28 d a semi-purified, hypercholesterolaemic diet (5% dietary fat and 0.25% cholesterol) supplemented at the 2% level with either the t8, c10+c9, t11-CLA mixture, c9, t11-CLA or trans-10, cis-12 (t10, c12)-CLA replacing lard and safflower-seed oil (control). Results show that compared with control, the t8, c10+c9, t11-CLA mixture and t10, c12-CLA-fed animals had lower (P < 0.0001) fat mass following supplementation. Animals consuming t10, c12-CLA also possessed higher lean mass compared with control and c9, t11-CLA groups (P < 0.001). However, the livers of these animals were larger (P < 0.0001) compared with those in the control and other CLA groups. Body weights of the hamsters did not differ across the experimental groups. CLA treatments had no effect on serum glucose or lipid profile, except for inducing higher (P < 0.05) non-HDL-cholesterol concentration with t10, c12-CLA compared with the c9, t11 isomer. Overall, these results indicate that in male hamsters fed a hypercholesterolaemic diet, the t8, c10+c9, t11-CLA mixture does not have an impact on blood lipid profile, but is able to effectively reduce fat mass, without incurring an accompanying liver enlargement.

Authors+Show Affiliations

Department of Food Science and Nutrition, Laval University, Quebec, QC, Canada G1V 0A6.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20609266

Citation

Joseph, Shama V., et al. "Trans-8, Cis-10+ Cis-9, Trans-11-conjugated Linoleic Acid Mixture Alters Body Composition in Syrian Golden Hamsters Fed a Hypercholesterolaemic Diet." The British Journal of Nutrition, vol. 104, no. 10, 2010, pp. 1443-9.
Joseph SV, Liu X, Wakefield A, et al. Trans-8, cis-10+ cis-9, trans-11-conjugated linoleic acid mixture alters body composition in Syrian golden hamsters fed a hypercholesterolaemic diet. Br J Nutr. 2010;104(10):1443-9.
Joseph, S. V., Liu, X., Wakefield, A., Chouinard, P. Y., Aukema, H., Jones, P. J., & Jacques, H. (2010). Trans-8, cis-10+ cis-9, trans-11-conjugated linoleic acid mixture alters body composition in Syrian golden hamsters fed a hypercholesterolaemic diet. The British Journal of Nutrition, 104(10), 1443-9. https://doi.org/10.1017/S0007114510002345
Joseph SV, et al. Trans-8, Cis-10+ Cis-9, Trans-11-conjugated Linoleic Acid Mixture Alters Body Composition in Syrian Golden Hamsters Fed a Hypercholesterolaemic Diet. Br J Nutr. 2010;104(10):1443-9. PubMed PMID: 20609266.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Trans-8, cis-10+ cis-9, trans-11-conjugated linoleic acid mixture alters body composition in Syrian golden hamsters fed a hypercholesterolaemic diet. AU - Joseph,Shama V, AU - Liu,Xiaoran, AU - Wakefield,Andrew, AU - Chouinard,P Yvan, AU - Aukema,Harold, AU - Jones,Peter J H, AU - Jacques,Hélène, Y1 - 2010/07/08/ PY - 2010/7/9/entrez PY - 2010/7/9/pubmed PY - 2010/12/17/medline SP - 1443 EP - 9 JF - The British journal of nutrition JO - Br J Nutr VL - 104 IS - 10 N2 - The effectiveness of conjugated linoleic acid (CLA) as a weight-loss nutraceutical continues to be debatable, suggesting that there may be value in exploring the physiological effects of the lesser-known isomers. The effects of the minor isomer, trans-8, cis-10 (t8, c10)-CLA, in the form of an equimolar mixture with the cis-9, trans-11 (c9, t11) isomer, on body weight and body composition, circulating glucose and lipid concentrations, and liver weights were studied in sixty male Syrian golden hamsters. Animals were randomised to receive for 28 d a semi-purified, hypercholesterolaemic diet (5% dietary fat and 0.25% cholesterol) supplemented at the 2% level with either the t8, c10+c9, t11-CLA mixture, c9, t11-CLA or trans-10, cis-12 (t10, c12)-CLA replacing lard and safflower-seed oil (control). Results show that compared with control, the t8, c10+c9, t11-CLA mixture and t10, c12-CLA-fed animals had lower (P < 0.0001) fat mass following supplementation. Animals consuming t10, c12-CLA also possessed higher lean mass compared with control and c9, t11-CLA groups (P < 0.001). However, the livers of these animals were larger (P < 0.0001) compared with those in the control and other CLA groups. Body weights of the hamsters did not differ across the experimental groups. CLA treatments had no effect on serum glucose or lipid profile, except for inducing higher (P < 0.05) non-HDL-cholesterol concentration with t10, c12-CLA compared with the c9, t11 isomer. Overall, these results indicate that in male hamsters fed a hypercholesterolaemic diet, the t8, c10+c9, t11-CLA mixture does not have an impact on blood lipid profile, but is able to effectively reduce fat mass, without incurring an accompanying liver enlargement. SN - 1475-2662 UR - https://www.unboundmedicine.com/medline/citation/20609266/Trans_8_cis_10+_cis_9_trans_11_conjugated_linoleic_acid_mixture_alters_body_composition_in_Syrian_golden_hamsters_fed_a_hypercholesterolaemic_diet_ L2 - https://www.cambridge.org/core/product/identifier/S0007114510002345/type/journal_article DB - PRIME DP - Unbound Medicine ER -