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GPR109a agonists. Part 2: pyrazole-acids as agonists of the human orphan G-protein coupled receptor GPR109a.
Bioorg Med Chem Lett. 2010 Aug 01; 20(15):4472-4.BM

Abstract

5-Alkyl and aryl-pyrazole-acids have been identified as a new class of selective, small-molecule, agonists of the human orphan G-protein-coupled receptor GPR109a, a high affinity receptor for the HDL-raising drug nicotinic acid.

Authors+Show Affiliations

Department of Medicinal Chemistry, Merck Research Laboratories, Merck & Co., Inc., Rahway, NJ 07065-0900, USA. jason_imbriglio@merck.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

20615702

Citation

Imbriglio, Jason E., et al. "GPR109a Agonists. Part 2: Pyrazole-acids as Agonists of the Human Orphan G-protein Coupled Receptor GPR109a." Bioorganic & Medicinal Chemistry Letters, vol. 20, no. 15, 2010, pp. 4472-4.
Imbriglio JE, Chang S, Liang R, et al. GPR109a agonists. Part 2: pyrazole-acids as agonists of the human orphan G-protein coupled receptor GPR109a. Bioorg Med Chem Lett. 2010;20(15):4472-4.
Imbriglio, J. E., Chang, S., Liang, R., Raghavan, S., Schmidt, D., Smenton, A., Tria, S., Schrader, T. O., Jung, J. K., Esser, C., Holt, T. G., Wolff, M. S., Taggart, A. K., Cheng, K., Carballo-Jane, E., Waters, M. G., Tata, J. R., & Colletti, S. L. (2010). GPR109a agonists. Part 2: pyrazole-acids as agonists of the human orphan G-protein coupled receptor GPR109a. Bioorganic & Medicinal Chemistry Letters, 20(15), 4472-4. https://doi.org/10.1016/j.bmcl.2010.06.041
Imbriglio JE, et al. GPR109a Agonists. Part 2: Pyrazole-acids as Agonists of the Human Orphan G-protein Coupled Receptor GPR109a. Bioorg Med Chem Lett. 2010 Aug 1;20(15):4472-4. PubMed PMID: 20615702.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - GPR109a agonists. Part 2: pyrazole-acids as agonists of the human orphan G-protein coupled receptor GPR109a. AU - Imbriglio,Jason E, AU - Chang,Sookhee, AU - Liang,Rui, AU - Raghavan,Subharekha, AU - Schmidt,Darby, AU - Smenton,Abby, AU - Tria,Scott, AU - Schrader,Thomas O, AU - Jung,Jae-Kyu, AU - Esser,Craig, AU - Holt,Tom G, AU - Wolff,Michael S, AU - Taggart,Andrew K P, AU - Cheng,Kang, AU - Carballo-Jane,Ester, AU - Waters,M Gerard, AU - Tata,James R, AU - Colletti,Steven L, Y1 - 2010/06/10/ PY - 2010/05/07/received PY - 2010/06/07/accepted PY - 2010/7/10/entrez PY - 2010/7/10/pubmed PY - 2010/12/14/medline SP - 4472 EP - 4 JF - Bioorganic & medicinal chemistry letters JO - Bioorg Med Chem Lett VL - 20 IS - 15 N2 - 5-Alkyl and aryl-pyrazole-acids have been identified as a new class of selective, small-molecule, agonists of the human orphan G-protein-coupled receptor GPR109a, a high affinity receptor for the HDL-raising drug nicotinic acid. SN - 1464-3405 UR - https://www.unboundmedicine.com/medline/citation/20615702/GPR109a_agonists__Part_2:_pyrazole_acids_as_agonists_of_the_human_orphan_G_protein_coupled_receptor_GPR109a_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0960-894X(10)00815-2 DB - PRIME DP - Unbound Medicine ER -