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A rare case of chronic lymphocytic leukemia with hypercalcemia induced by elevated parathyroid hormone-related peptides.
Acta Haematol. 2010; 124(1):57-60.AH

Abstract

Hypercalcemia in malignancies is a frequent complication, mostly affecting patients with solid tumors or multiple myeloma. Calcium elevation is induced by direct bone infiltration of a tumor mass or through calcium liberation from the skeleton by a humoral mediator. The latter mechanism is referred to as humoral hypercalcemia of malignancy (HHM). Frequent mediators of HHM are parathyroid hormone-related peptides (PTHrP). We report a patient with chronic lymphocytic leukemia and hypercalcemia induced by PTHrP. In contrast to solid tumors and myeloma, PTHrP-induced HHM is very rare in low-grad lymphoma including chronic lymphocytic leukemia. Therapeutical approaches consist of cytoreductive treatment and calcium-lowering therapy with bisphosphonates.

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Authors+Show Affiliations

Kampfenkel T
Department of Internal Medicine, Knappschaftskrankenhaus, Ruhr-University Bochum, Bochum, Germany. tobias.kampfenkel@rub.de
Baraniskin A
No affiliation info available
Teschendorf C
No affiliation info available
Schmiegel W
No affiliation info available
Massenkeil G
No affiliation info available

MeSH

DiphosphonatesHumansHypercalcemiaLeukemia, Lymphocytic, Chronic, B-CellMaleMiddle AgedParathyroid Hormone-Related Protein

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

20616540

Citation

Kampfenkel, Tobias, et al. "A Rare Case of Chronic Lymphocytic Leukemia With Hypercalcemia Induced By Elevated Parathyroid Hormone-related Peptides." Acta Haematologica, vol. 124, no. 1, 2010, pp. 57-60.
Kampfenkel T, Baraniskin A, Teschendorf C, et al. A rare case of chronic lymphocytic leukemia with hypercalcemia induced by elevated parathyroid hormone-related peptides. Acta Haematol. 2010;124(1):57-60.
Kampfenkel, T., Baraniskin, A., Teschendorf, C., Schmiegel, W., & Massenkeil, G. (2010). A rare case of chronic lymphocytic leukemia with hypercalcemia induced by elevated parathyroid hormone-related peptides. Acta Haematologica, 124(1), 57-60. https://doi.org/10.1159/000314646
Kampfenkel T, et al. A Rare Case of Chronic Lymphocytic Leukemia With Hypercalcemia Induced By Elevated Parathyroid Hormone-related Peptides. Acta Haematol. 2010;124(1):57-60. PubMed PMID: 20616540.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A rare case of chronic lymphocytic leukemia with hypercalcemia induced by elevated parathyroid hormone-related peptides. AU - Kampfenkel,Tobias, AU - Baraniskin,A, AU - Teschendorf,C, AU - Schmiegel,W, AU - Massenkeil,G, Y1 - 2010/07/09/ PY - 2009/11/09/received PY - 2010/04/29/accepted PY - 2010/7/10/entrez PY - 2010/7/10/pubmed PY - 2010/8/18/medline SP - 57 EP - 60 JF - Acta haematologica JO - Acta Haematol VL - 124 IS - 1 N2 - Hypercalcemia in malignancies is a frequent complication, mostly affecting patients with solid tumors or multiple myeloma. Calcium elevation is induced by direct bone infiltration of a tumor mass or through calcium liberation from the skeleton by a humoral mediator. The latter mechanism is referred to as humoral hypercalcemia of malignancy (HHM). Frequent mediators of HHM are parathyroid hormone-related peptides (PTHrP). We report a patient with chronic lymphocytic leukemia and hypercalcemia induced by PTHrP. In contrast to solid tumors and myeloma, PTHrP-induced HHM is very rare in low-grad lymphoma including chronic lymphocytic leukemia. Therapeutical approaches consist of cytoreductive treatment and calcium-lowering therapy with bisphosphonates. SN - 1421-9662 UR - https://www.unboundmedicine.com/medline/citation/20616540/A_rare_case_of_chronic_lymphocytic_leukemia_with_hypercalcemia_induced_by_elevated_parathyroid_hormone_related_peptides_ L2 - https://www.karger.com?DOI=10.1159/000314646 DB - PRIME DP - Unbound Medicine ER -