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The effect of Semax and its C-end peptide PGP on the morphology and proliferative activity of rat brain cells during experimental ischemia: a pilot study.
J Mol Neurosci. 2011 Oct; 45(2):177-85.JM

Abstract

The neuropeptide preparation Semax (Met-Glu-His-Phe-Pro-Gly-Pro) has been employed successfully in clinical practice for treating patients with severe brain blood circulation disorders. In spite of numerous studies, many aspects of the therapeutic effects of this preparation remain unknown. In this context, the effects of Semax and its C-end tripeptide PGP on the functional morphology of nervous tissue cells were studied in the normal rat brain and in a model of incomplete global rat brain ischemia. In control animals, both peptides activated the capillary network and caused similar morphological changes to neurons and the neuropil regions. We show here for the first time at the histological level that Semax and PGP increased proliferation of the neuroglia, blood vessel endothelium, and progenitor cells in the subventricular zone. In these experimental conditions, only Semax abated the manifestation of ischemic damage to the nervous tissue. This was probably attributable to a decrease in vascular stasis symptoms as well as the trophic effect of the peptide.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Stavchansky VV
Human Molecular Genetics Department, Institute of Molecular Genetics of the Russian Academy of Sciences, 123182 Kurchatov sq., 2, Moscow, Russia. bacbac@yandex.ru
Yuzhakov VV
No affiliation info available
Botsina AY
No affiliation info available
Skvortsova VI
No affiliation info available
Bondurko LN
No affiliation info available
Tsyganova MG
No affiliation info available
Limborska SA
No affiliation info available
Myasoedov NF
No affiliation info available
Dergunova LV
No affiliation info available

MeSH

Adrenocorticotropic HormoneAnimalsBrainBrain IschemiaCell ProliferationHumansMaleNeuroprotective AgentsOligopeptidesPeptide FragmentsPilot ProjectsProlineRatsRats, Wistar

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20617398

Citation

Stavchansky, Vasily V., et al. "The Effect of Semax and Its C-end Peptide PGP On the Morphology and Proliferative Activity of Rat Brain Cells During Experimental Ischemia: a Pilot Study." Journal of Molecular Neuroscience : MN, vol. 45, no. 2, 2011, pp. 177-85.
Stavchansky VV, Yuzhakov VV, Botsina AY, et al. The effect of Semax and its C-end peptide PGP on the morphology and proliferative activity of rat brain cells during experimental ischemia: a pilot study. J Mol Neurosci. 2011;45(2):177-85.
Stavchansky, V. V., Yuzhakov, V. V., Botsina, A. Y., Skvortsova, V. I., Bondurko, L. N., Tsyganova, M. G., Limborska, S. A., Myasoedov, N. F., & Dergunova, L. V. (2011). The effect of Semax and its C-end peptide PGP on the morphology and proliferative activity of rat brain cells during experimental ischemia: a pilot study. Journal of Molecular Neuroscience : MN, 45(2), 177-85. https://doi.org/10.1007/s12031-010-9421-2
Stavchansky VV, et al. The Effect of Semax and Its C-end Peptide PGP On the Morphology and Proliferative Activity of Rat Brain Cells During Experimental Ischemia: a Pilot Study. J Mol Neurosci. 2011;45(2):177-85. PubMed PMID: 20617398.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effect of Semax and its C-end peptide PGP on the morphology and proliferative activity of rat brain cells during experimental ischemia: a pilot study. AU - Stavchansky,Vasily V, AU - Yuzhakov,Vadim V, AU - Botsina,Alexandra Yu, AU - Skvortsova,Veronika I, AU - Bondurko,Lyubov N, AU - Tsyganova,Marina G, AU - Limborska,Svetlana A, AU - Myasoedov,Nikolay F, AU - Dergunova,Lyudmila V, Y1 - 2010/07/09/ PY - 2010/05/26/received PY - 2010/06/25/accepted PY - 2010/7/10/entrez PY - 2010/7/10/pubmed PY - 2012/4/25/medline SP - 177 EP - 85 JF - Journal of molecular neuroscience : MN JO - J Mol Neurosci VL - 45 IS - 2 N2 - The neuropeptide preparation Semax (Met-Glu-His-Phe-Pro-Gly-Pro) has been employed successfully in clinical practice for treating patients with severe brain blood circulation disorders. In spite of numerous studies, many aspects of the therapeutic effects of this preparation remain unknown. In this context, the effects of Semax and its C-end tripeptide PGP on the functional morphology of nervous tissue cells were studied in the normal rat brain and in a model of incomplete global rat brain ischemia. In control animals, both peptides activated the capillary network and caused similar morphological changes to neurons and the neuropil regions. We show here for the first time at the histological level that Semax and PGP increased proliferation of the neuroglia, blood vessel endothelium, and progenitor cells in the subventricular zone. In these experimental conditions, only Semax abated the manifestation of ischemic damage to the nervous tissue. This was probably attributable to a decrease in vascular stasis symptoms as well as the trophic effect of the peptide. SN - 1559-1166 UR - https://www.unboundmedicine.com/medline/citation/20617398/The_effect_of_Semax_and_its_C_end_peptide_PGP_on_the_morphology_and_proliferative_activity_of_rat_brain_cells_during_experimental_ischemia:_a_pilot_study_ L2 - https://dx.doi.org/10.1007/s12031-010-9421-2 DB - PRIME DP - Unbound Medicine ER -