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Ovarian morphology and prevalence of polycystic ovary syndrome in reproductive aged women with or without mild acne.
Int J Dermatol. 2010 Jul; 49(7):775-9.IJ

Abstract

BACKGROUND

Acne and hirsutism are common manifestations of hyperandrogenemia. They may also be a sign of underlying severe diseases. Aim To compare ovarian morphology and prevalence of polycystic ovary syndrome (PCOS) in reproductive aged women with or without mild acne and hirsutism.

METHODS

52 women with mild acne and 59 age-matched controls were included in this study. Main outcome measures were the prevalence of PCOS, ovarian morphology, and ovarian stromal thickness in both groups, and acne and hirsutism subgroups. Patients in both groups were taking no hormonal therapy at that time. Androgen profiles were compared between the two groups.

RESULTS

The prevalence of PCOS was 17.1% (19/111) in all women included in this study. In the acne group, the prevalence of PCOS was 26.9% (14/52), and significantly more prevalent than in control group [8.4% (5/59), P = 0.001]. Total ovarian volume was significantly larger and stromal thickness of the ovary was thicker in women with acne than women without acne. There were no statistically significant difference between the two groups in terms of dehydroepiandrosterone sulfate, and 17-hydroxyprogesterone, respectively, while serum total testosterone levels were significantly higher (P < 0.05) in women with acne than those women in the control group.

CONCLUSIONS

Acne and hirsutism may not only cause cosmetic concern but may also be a sign of underlying PCOS. Therefore, women presenting with acne and/or hirsutism should be evaluated in terms of PCOS.

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Authors+Show Affiliations

Kelekci KH
Dermatology Clinic, Numune Education and Research Hospital, Adana, Turkey. drhandankelekci@yahoo.com
Kelekci S
No affiliation info available
Incki K
No affiliation info available
Ozdemir O
No affiliation info available
Yilmaz B
No affiliation info available

MeSH

17-alpha-HydroxyprogesteroneAcne VulgarisAdolescentAdultAge of OnsetCross-Sectional StudiesDehydroepiandrosteroneFemaleHirsutismHumansHyperandrogenismOvaryPolycystic Ovary SyndromePrevalenceSeverity of Illness IndexTestosteroneYoung Adult

Pub Type(s)

Journal Article

Language

eng

PubMed ID

20618496

Citation

Kelekci, Kiymet Handan, et al. "Ovarian Morphology and Prevalence of Polycystic Ovary Syndrome in Reproductive Aged Women With or Without Mild Acne." International Journal of Dermatology, vol. 49, no. 7, 2010, pp. 775-9.
Kelekci KH, Kelekci S, Incki K, et al. Ovarian morphology and prevalence of polycystic ovary syndrome in reproductive aged women with or without mild acne. Int J Dermatol. 2010;49(7):775-9.
Kelekci, K. H., Kelekci, S., Incki, K., Ozdemir, O., & Yilmaz, B. (2010). Ovarian morphology and prevalence of polycystic ovary syndrome in reproductive aged women with or without mild acne. International Journal of Dermatology, 49(7), 775-9. https://doi.org/10.1111/j.1365-4632.2009.04389.x
Kelekci KH, et al. Ovarian Morphology and Prevalence of Polycystic Ovary Syndrome in Reproductive Aged Women With or Without Mild Acne. Int J Dermatol. 2010;49(7):775-9. PubMed PMID: 20618496.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ovarian morphology and prevalence of polycystic ovary syndrome in reproductive aged women with or without mild acne. AU - Kelekci,Kiymet Handan, AU - Kelekci,Sefa, AU - Incki,Kuntay, AU - Ozdemir,Orcun, AU - Yilmaz,Bulent, PY - 2010/7/13/entrez PY - 2010/7/14/pubmed PY - 2010/10/23/medline SP - 775 EP - 9 JF - International journal of dermatology JO - Int J Dermatol VL - 49 IS - 7 N2 - BACKGROUND: Acne and hirsutism are common manifestations of hyperandrogenemia. They may also be a sign of underlying severe diseases. Aim To compare ovarian morphology and prevalence of polycystic ovary syndrome (PCOS) in reproductive aged women with or without mild acne and hirsutism. METHODS: 52 women with mild acne and 59 age-matched controls were included in this study. Main outcome measures were the prevalence of PCOS, ovarian morphology, and ovarian stromal thickness in both groups, and acne and hirsutism subgroups. Patients in both groups were taking no hormonal therapy at that time. Androgen profiles were compared between the two groups. RESULTS: The prevalence of PCOS was 17.1% (19/111) in all women included in this study. In the acne group, the prevalence of PCOS was 26.9% (14/52), and significantly more prevalent than in control group [8.4% (5/59), P = 0.001]. Total ovarian volume was significantly larger and stromal thickness of the ovary was thicker in women with acne than women without acne. There were no statistically significant difference between the two groups in terms of dehydroepiandrosterone sulfate, and 17-hydroxyprogesterone, respectively, while serum total testosterone levels were significantly higher (P < 0.05) in women with acne than those women in the control group. CONCLUSIONS: Acne and hirsutism may not only cause cosmetic concern but may also be a sign of underlying PCOS. Therefore, women presenting with acne and/or hirsutism should be evaluated in terms of PCOS. SN - 1365-4632 UR - https://www.unboundmedicine.com/medline/citation/20618496/Ovarian_morphology_and_prevalence_of_polycystic_ovary_syndrome_in_reproductive_aged_women_with_or_without_mild_acne_ L2 - https://doi.org/10.1111/j.1365-4632.2009.04389.x DB - PRIME DP - Unbound Medicine ER -