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Factors associated with upgrading to malignancy at surgery of atypical ductal hyperplasia diagnosed on core biopsy.
Breast. 2011 Feb; 20(1):50-5.B

Abstract

Previous studies have shown that 4-54% of breast lesions reported on core biopsies as atypical ductal hyperplasia (ADH) are upgraded on further excision to ductal carcinoma in situ (DCIS) or invasive carcinoma. We evaluated the rate of upgrading ADH to carcinoma at surgery for ADH diagnosed by percutaneous biopsy, and examined characteristics associated with malignancy. We identified 13,488 consecutive biopsies conducted at one center over a nine-year period. A total of 422 biopsies with ADH in 415 patients were included. DCIS or invasive carcinoma was found in 132 cases (31.3% upgrading). Multivariate model revealed that ipsilateral breast symptoms, mammographic lesion other than microcalcifications alone, 14G core needle biopsy, papilloma co-diagnosis, severe ADH and pathologists with lower volume of ADH diagnosis were factors statistically associated with malignancy. However, no subgroups were identified for safe clinical-only follow-up. Surgery is recommended in all cases of ADH diagnosed by percutaneous breast biopsy.

Authors+Show Affiliations

Centre des Maladies du Sein Deschênes-Fabia, Hôpital du Saint-Sacrement, 1050 chemin Ste-Foy, Quebec City, QC, Canada. isabelle.deshaies@gmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20619647

Citation

Deshaies, Isabelle, et al. "Factors Associated With Upgrading to Malignancy at Surgery of Atypical Ductal Hyperplasia Diagnosed On Core Biopsy." Breast (Edinburgh, Scotland), vol. 20, no. 1, 2011, pp. 50-5.
Deshaies I, Provencher L, Jacob S, et al. Factors associated with upgrading to malignancy at surgery of atypical ductal hyperplasia diagnosed on core biopsy. Breast. 2011;20(1):50-5.
Deshaies, I., Provencher, L., Jacob, S., Côté, G., Robert, J., Desbiens, C., Poirier, B., Hogue, J. C., Vachon, E., & Diorio, C. (2011). Factors associated with upgrading to malignancy at surgery of atypical ductal hyperplasia diagnosed on core biopsy. Breast (Edinburgh, Scotland), 20(1), 50-5. https://doi.org/10.1016/j.breast.2010.06.004
Deshaies I, et al. Factors Associated With Upgrading to Malignancy at Surgery of Atypical Ductal Hyperplasia Diagnosed On Core Biopsy. Breast. 2011;20(1):50-5. PubMed PMID: 20619647.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Factors associated with upgrading to malignancy at surgery of atypical ductal hyperplasia diagnosed on core biopsy. AU - Deshaies,Isabelle, AU - Provencher,Louise, AU - Jacob,Simon, AU - Côté,Gary, AU - Robert,Jean, AU - Desbiens,Christine, AU - Poirier,Brigitte, AU - Hogue,Jean-Charles, AU - Vachon,Eric, AU - Diorio,Caroline, Y1 - 2010/07/08/ PY - 2010/04/19/received PY - 2010/06/14/revised PY - 2010/06/15/accepted PY - 2010/7/13/entrez PY - 2010/7/14/pubmed PY - 2011/6/11/medline SP - 50 EP - 5 JF - Breast (Edinburgh, Scotland) JO - Breast VL - 20 IS - 1 N2 - Previous studies have shown that 4-54% of breast lesions reported on core biopsies as atypical ductal hyperplasia (ADH) are upgraded on further excision to ductal carcinoma in situ (DCIS) or invasive carcinoma. We evaluated the rate of upgrading ADH to carcinoma at surgery for ADH diagnosed by percutaneous biopsy, and examined characteristics associated with malignancy. We identified 13,488 consecutive biopsies conducted at one center over a nine-year period. A total of 422 biopsies with ADH in 415 patients were included. DCIS or invasive carcinoma was found in 132 cases (31.3% upgrading). Multivariate model revealed that ipsilateral breast symptoms, mammographic lesion other than microcalcifications alone, 14G core needle biopsy, papilloma co-diagnosis, severe ADH and pathologists with lower volume of ADH diagnosis were factors statistically associated with malignancy. However, no subgroups were identified for safe clinical-only follow-up. Surgery is recommended in all cases of ADH diagnosed by percutaneous breast biopsy. SN - 1532-3080 UR - https://www.unboundmedicine.com/medline/citation/20619647/Factors_associated_with_upgrading_to_malignancy_at_surgery_of_atypical_ductal_hyperplasia_diagnosed_on_core_biopsy_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0960-9776(10)00154-2 DB - PRIME DP - Unbound Medicine ER -