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Intake of fruits and vegetables, and risk of endometrial cancer in the NIH-AARP Diet and Health Study.
Cancer Epidemiol 2010; 34(5):568-73CE

Abstract

BACKGROUND

Fruits and vegetables contain a wide variety of phytochemicals which may have anti-carcinogenic effects. Although the results of case-control studies have suggested a possible protective effect of fruit and vegetable intake on the risk of endometrial carcinoma, few cohort studies have examined this association.

MATERIALS AND METHODS

We used data from the NIH-AARP Diet and Health Study to assess the association of fruit and vegetable consumption, as well as intake of specific botanical groupings of fruits and vegetables, with endometrial cancer risk among 112,088 women who completed a food-frequency questionnaire at baseline, in 1995-1996. During 8 years of follow-up 1142 incident cases of endometrial cancer were ascertained. Cox proportional hazards models were used to estimate hazard ratios (HR) and 95% confidence intervals (95% CI).

RESULTS

After adjustment for covariates, HRs for the highest compared to the lowest quintile of total fruit and total vegetable intake were 1.30 (95% CI 1.04-1.61, P for trend 0.05) and 1.09 (95% CI 0.90-1.33, P for trend 0.55), respectively. No inverse associations were observed for intake of any of 13 botanical groupings of fruits and vegetables.

CONCLUSIONS

Results from this large prospective study do not support a protective role of a high intake of fruits or vegetables on the risk of endometrial cancer in older women.

Authors+Show Affiliations

Department of Epidemiology and Population Health, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA. Geoffrey.kabat@einstein.yu.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

20619761

Citation

Kabat, Geoffrey C., et al. "Intake of Fruits and Vegetables, and Risk of Endometrial Cancer in the NIH-AARP Diet and Health Study." Cancer Epidemiology, vol. 34, no. 5, 2010, pp. 568-73.
Kabat GC, Park Y, Hollenbeck AR, et al. Intake of fruits and vegetables, and risk of endometrial cancer in the NIH-AARP Diet and Health Study. Cancer Epidemiol. 2010;34(5):568-73.
Kabat, G. C., Park, Y., Hollenbeck, A. R., Schatzkin, A., & Rohan, T. E. (2010). Intake of fruits and vegetables, and risk of endometrial cancer in the NIH-AARP Diet and Health Study. Cancer Epidemiology, 34(5), pp. 568-73. doi:10.1016/j.canep.2010.06.005.
Kabat GC, et al. Intake of Fruits and Vegetables, and Risk of Endometrial Cancer in the NIH-AARP Diet and Health Study. Cancer Epidemiol. 2010;34(5):568-73. PubMed PMID: 20619761.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Intake of fruits and vegetables, and risk of endometrial cancer in the NIH-AARP Diet and Health Study. AU - Kabat,Geoffrey C, AU - Park,Yikyung, AU - Hollenbeck,Albert R, AU - Schatzkin,Arthur, AU - Rohan,Thomas E, Y1 - 2010/07/08/ PY - 2010/03/30/received PY - 2010/06/10/revised PY - 2010/06/13/accepted PY - 2010/7/13/entrez PY - 2010/7/14/pubmed PY - 2010/12/14/medline SP - 568 EP - 73 JF - Cancer epidemiology JO - Cancer Epidemiol VL - 34 IS - 5 N2 - BACKGROUND: Fruits and vegetables contain a wide variety of phytochemicals which may have anti-carcinogenic effects. Although the results of case-control studies have suggested a possible protective effect of fruit and vegetable intake on the risk of endometrial carcinoma, few cohort studies have examined this association. MATERIALS AND METHODS: We used data from the NIH-AARP Diet and Health Study to assess the association of fruit and vegetable consumption, as well as intake of specific botanical groupings of fruits and vegetables, with endometrial cancer risk among 112,088 women who completed a food-frequency questionnaire at baseline, in 1995-1996. During 8 years of follow-up 1142 incident cases of endometrial cancer were ascertained. Cox proportional hazards models were used to estimate hazard ratios (HR) and 95% confidence intervals (95% CI). RESULTS: After adjustment for covariates, HRs for the highest compared to the lowest quintile of total fruit and total vegetable intake were 1.30 (95% CI 1.04-1.61, P for trend 0.05) and 1.09 (95% CI 0.90-1.33, P for trend 0.55), respectively. No inverse associations were observed for intake of any of 13 botanical groupings of fruits and vegetables. CONCLUSIONS: Results from this large prospective study do not support a protective role of a high intake of fruits or vegetables on the risk of endometrial cancer in older women. SN - 1877-783X UR - https://www.unboundmedicine.com/medline/citation/20619761/Intake_of_fruits_and_vegetables_and_risk_of_endometrial_cancer_in_the_NIH_AARP_Diet_and_Health_Study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1877-7821(10)00111-6 DB - PRIME DP - Unbound Medicine ER -