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Longitudinal MRI atrophy biomarkers: relationship to conversion in the ADNI cohort.
Neurobiol Aging 2010; 31(8):1401-18NA

Abstract

Atrophic changes in early Alzheimer's disease (AD) and amnestic mild cognitive impairment (MCI) have been proposed as biomarkers for detection and monitoring. We analyzed magnetic resonance imaging (MRI) atrophy rate from baseline to 1 year in 4 groups of participants from the Alzheimer's Disease Neuroimaging Initiative (ADNI): AD (n = 152), converters from MCI to probable AD (MCI-C, n = 60), stable MCI (MCI-S, n = 261), and healthy controls (HC, n = 200). Scans were analyzed using multiple methods, including voxel-based morphometry (VBM), regions of interest (ROIs), and automated parcellation, permitting comparison of annual percent change (APC) in neurodegeneration markers. Effect sizes and the sample required to detect 25% reduction in atrophy rates were calculated. The influence of APOE genotype on APC was also evaluated. AD patients and converters from MCI to probable AD demonstrated high atrophy APCs across regions compared with minimal change in healthy controls. Stable MCI subjects showed intermediate atrophy rates. APOE genotype was associated with APC in key regions. In sum, APC rates are influenced by APOE genotype, imminent MCI to AD conversion, and AD-related neurodegeneration.

Authors+Show Affiliations

Center for Neuroimaging, Department of Radiology and Imaging Sciences, Indiana University, School of Medicine, 950 W Walnut St., Indianapolis, IN 46202, United States.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Multicenter Study
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

20620664

Citation

Risacher, Shannon L., et al. "Longitudinal MRI Atrophy Biomarkers: Relationship to Conversion in the ADNI Cohort." Neurobiology of Aging, vol. 31, no. 8, 2010, pp. 1401-18.
Risacher SL, Shen L, West JD, et al. Longitudinal MRI atrophy biomarkers: relationship to conversion in the ADNI cohort. Neurobiol Aging. 2010;31(8):1401-18.
Risacher, S. L., Shen, L., West, J. D., Kim, S., McDonald, B. C., Beckett, L. A., ... Saykin, A. J. (2010). Longitudinal MRI atrophy biomarkers: relationship to conversion in the ADNI cohort. Neurobiology of Aging, 31(8), pp. 1401-18. doi:10.1016/j.neurobiolaging.2010.04.029.
Risacher SL, et al. Longitudinal MRI Atrophy Biomarkers: Relationship to Conversion in the ADNI Cohort. Neurobiol Aging. 2010;31(8):1401-18. PubMed PMID: 20620664.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Longitudinal MRI atrophy biomarkers: relationship to conversion in the ADNI cohort. AU - Risacher,Shannon L, AU - Shen,Li, AU - West,John D, AU - Kim,Sungeun, AU - McDonald,Brenna C, AU - Beckett,Laurel A, AU - Harvey,Danielle J, AU - Jack,Clifford R,Jr AU - Weiner,Michael W, AU - Saykin,Andrew J, AU - ,, PY - 2010/02/16/received PY - 2010/04/25/revised PY - 2010/04/27/accepted PY - 2010/7/13/entrez PY - 2010/7/14/pubmed PY - 2011/3/30/medline SP - 1401 EP - 18 JF - Neurobiology of aging JO - Neurobiol. Aging VL - 31 IS - 8 N2 - Atrophic changes in early Alzheimer's disease (AD) and amnestic mild cognitive impairment (MCI) have been proposed as biomarkers for detection and monitoring. We analyzed magnetic resonance imaging (MRI) atrophy rate from baseline to 1 year in 4 groups of participants from the Alzheimer's Disease Neuroimaging Initiative (ADNI): AD (n = 152), converters from MCI to probable AD (MCI-C, n = 60), stable MCI (MCI-S, n = 261), and healthy controls (HC, n = 200). Scans were analyzed using multiple methods, including voxel-based morphometry (VBM), regions of interest (ROIs), and automated parcellation, permitting comparison of annual percent change (APC) in neurodegeneration markers. Effect sizes and the sample required to detect 25% reduction in atrophy rates were calculated. The influence of APOE genotype on APC was also evaluated. AD patients and converters from MCI to probable AD demonstrated high atrophy APCs across regions compared with minimal change in healthy controls. Stable MCI subjects showed intermediate atrophy rates. APOE genotype was associated with APC in key regions. In sum, APC rates are influenced by APOE genotype, imminent MCI to AD conversion, and AD-related neurodegeneration. SN - 1558-1497 UR - https://www.unboundmedicine.com/medline/citation/20620664/Longitudinal_MRI_atrophy_biomarkers:_relationship_to_conversion_in_the_ADNI_cohort_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0197-4580(10)00204-6 DB - PRIME DP - Unbound Medicine ER -