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Nutrition and aging skin: sugar and glycation.
Clin Dermatol. 2010 Jul-Aug; 28(4):409-11.CD

Abstract

The effect of sugars on aging skin is governed by the simple act of covalently cross-linking two collagen fibers, which renders both of them incapable of easy repair. Glucose and fructose link the amino acids present in the collagen and elastin that support the dermis, producing advanced glycation end products or "AGEs." This process is accelerated in all body tissues when sugar is elevated and is further stimulated by ultraviolet light in the skin. The effect on vascular, renal, retinal, coronary, and cutaneous tissues is being defined, as are methods of reducing the glycation load through careful diet and use of supplements.

Authors+Show Affiliations

Department of Medicine, Section of Dermatology, Dartmouth Medical School, Hanover, NH 03104, USA. fwdljm@tds.net

Pub Type(s)

Journal Article

Language

eng

PubMed ID

20620757

Citation

Danby, F William. "Nutrition and Aging Skin: Sugar and Glycation." Clinics in Dermatology, vol. 28, no. 4, 2010, pp. 409-11.
Danby FW. Nutrition and aging skin: sugar and glycation. Clin Dermatol. 2010;28(4):409-11.
Danby, F. W. (2010). Nutrition and aging skin: sugar and glycation. Clinics in Dermatology, 28(4), 409-11. https://doi.org/10.1016/j.clindermatol.2010.03.018
Danby FW. Nutrition and Aging Skin: Sugar and Glycation. Clin Dermatol. 2010 Jul-Aug;28(4):409-11. PubMed PMID: 20620757.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Nutrition and aging skin: sugar and glycation. A1 - Danby,F William, PY - 2010/7/13/entrez PY - 2010/7/14/pubmed PY - 2010/10/21/medline SP - 409 EP - 11 JF - Clinics in dermatology JO - Clin. Dermatol. VL - 28 IS - 4 N2 - The effect of sugars on aging skin is governed by the simple act of covalently cross-linking two collagen fibers, which renders both of them incapable of easy repair. Glucose and fructose link the amino acids present in the collagen and elastin that support the dermis, producing advanced glycation end products or "AGEs." This process is accelerated in all body tissues when sugar is elevated and is further stimulated by ultraviolet light in the skin. The effect on vascular, renal, retinal, coronary, and cutaneous tissues is being defined, as are methods of reducing the glycation load through careful diet and use of supplements. SN - 1879-1131 UR - https://www.unboundmedicine.com/medline/citation/20620757/Nutrition_and_aging_skin:_sugar_and_glycation_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0738-081X(10)00042-8 DB - PRIME DP - Unbound Medicine ER -