TY - JOUR T1 - Nutrition and aging skin: sugar and glycation. A1 - Danby,F William, PY - 2010/7/13/entrez PY - 2010/7/14/pubmed PY - 2010/10/21/medline SP - 409 EP - 11 JF - Clinics in dermatology JO - Clin Dermatol VL - 28 IS - 4 N2 - The effect of sugars on aging skin is governed by the simple act of covalently cross-linking two collagen fibers, which renders both of them incapable of easy repair. Glucose and fructose link the amino acids present in the collagen and elastin that support the dermis, producing advanced glycation end products or "AGEs." This process is accelerated in all body tissues when sugar is elevated and is further stimulated by ultraviolet light in the skin. The effect on vascular, renal, retinal, coronary, and cutaneous tissues is being defined, as are methods of reducing the glycation load through careful diet and use of supplements. SN - 1879-1131 UR - https://www.unboundmedicine.com/medline/citation/20620757/Nutrition_and_aging_skin:_sugar_and_glycation_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0738-081X(10)00042-8 DB - PRIME DP - Unbound Medicine ER -