Tags

Type your tag names separated by a space and hit enter

Exposure to the Chinese famine in early life and the risk of hyperglycemia and type 2 diabetes in adulthood.
Diabetes 2010; 59(10):2400-6D

Abstract

OBJECTIVE

Early developmental adaptations in response to undernutrition may play an essential role in susceptibility to type 2 diabetes, particularly for those experiencing a "mismatched rich nutritional environment" in later life. We examined the associations of exposure to the Chinese famine (1959-1961) during fetal life and childhood with the risk of hyperglycemia and type 2 diabetes in adulthood.

RESEARCH DESIGN AND METHODS

We used the data for 7,874 rural adults born between 1954 and 1964 in selected communities from the cross-sectional 2002 China National Nutrition and Health Survey. Hyperglycemia was defined as fasting plasma glucose ≥6.1 mmol/l and/or 2-h plasma glucose ≥7.8 mmol/l and/or a previous clinical diagnosis of type 2 diabetes.

RESULTS

Prevalences of hyperglycemia among adults in nonexposed, fetal exposed, early-childhood, mid-childhood, and late-childhood exposed cohorts were 2.4%, 5.7%, 3.9%, 3.4%, and 5.9%, respectively. In severely affected famine areas, fetal-exposed subjects had an increased risk of hyperglycemia compared with nonexposed subjects (odds ratio = 3.92; 95% CI: 1.64-9.39; P = 0.002); this difference was not observed in less severely affected famine areas (odds ratio = 0.57; 95% CI: 0.25-1.31; P = 0.185). The odds ratios were significantly different between groups from the severe and less severe famine areas (P for interaction = 0.001). In severely affected famine areas, fetal-exposed subjects who followed an affluent/Western dietary pattern (odds ratios = 7.63; 95% CI: 2.41-24.1; P = 0.0005) or who had a higher economic status in later life experienced a substantially elevated risk of hyperglycemia (odds ratios = 6.20; 95% CI: 2.08-18.5; P = 0.001).

CONCLUSIONS

Fetal exposure to the severe Chinese famine increases the risk of hyperglycemia in adulthood. This association appears to be exacerbated by a nutritionally rich environment in later life.

Authors+Show Affiliations

National Institute for Nutrition and Food Safety, Chinese Center for Disease Control and Prevention, Beijing, China. liyanping72@yahoo.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20622161

Citation

Li, Yanping, et al. "Exposure to the Chinese Famine in Early Life and the Risk of Hyperglycemia and Type 2 Diabetes in Adulthood." Diabetes, vol. 59, no. 10, 2010, pp. 2400-6.
Li Y, He Y, Qi L, et al. Exposure to the Chinese famine in early life and the risk of hyperglycemia and type 2 diabetes in adulthood. Diabetes. 2010;59(10):2400-6.
Li, Y., He, Y., Qi, L., Jaddoe, V. W., Feskens, E. J., Yang, X., ... Hu, F. B. (2010). Exposure to the Chinese famine in early life and the risk of hyperglycemia and type 2 diabetes in adulthood. Diabetes, 59(10), pp. 2400-6. doi:10.2337/db10-0385.
Li Y, et al. Exposure to the Chinese Famine in Early Life and the Risk of Hyperglycemia and Type 2 Diabetes in Adulthood. Diabetes. 2010;59(10):2400-6. PubMed PMID: 20622161.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Exposure to the Chinese famine in early life and the risk of hyperglycemia and type 2 diabetes in adulthood. AU - Li,Yanping, AU - He,Yuna, AU - Qi,Lu, AU - Jaddoe,Vincent W, AU - Feskens,Edith J M, AU - Yang,Xiaoguang, AU - Ma,Guansheng, AU - Hu,Frank B, Y1 - 2010/07/09/ PY - 2010/7/13/entrez PY - 2010/7/14/pubmed PY - 2010/10/30/medline SP - 2400 EP - 6 JF - Diabetes JO - Diabetes VL - 59 IS - 10 N2 - OBJECTIVE: Early developmental adaptations in response to undernutrition may play an essential role in susceptibility to type 2 diabetes, particularly for those experiencing a "mismatched rich nutritional environment" in later life. We examined the associations of exposure to the Chinese famine (1959-1961) during fetal life and childhood with the risk of hyperglycemia and type 2 diabetes in adulthood. RESEARCH DESIGN AND METHODS: We used the data for 7,874 rural adults born between 1954 and 1964 in selected communities from the cross-sectional 2002 China National Nutrition and Health Survey. Hyperglycemia was defined as fasting plasma glucose ≥6.1 mmol/l and/or 2-h plasma glucose ≥7.8 mmol/l and/or a previous clinical diagnosis of type 2 diabetes. RESULTS: Prevalences of hyperglycemia among adults in nonexposed, fetal exposed, early-childhood, mid-childhood, and late-childhood exposed cohorts were 2.4%, 5.7%, 3.9%, 3.4%, and 5.9%, respectively. In severely affected famine areas, fetal-exposed subjects had an increased risk of hyperglycemia compared with nonexposed subjects (odds ratio = 3.92; 95% CI: 1.64-9.39; P = 0.002); this difference was not observed in less severely affected famine areas (odds ratio = 0.57; 95% CI: 0.25-1.31; P = 0.185). The odds ratios were significantly different between groups from the severe and less severe famine areas (P for interaction = 0.001). In severely affected famine areas, fetal-exposed subjects who followed an affluent/Western dietary pattern (odds ratios = 7.63; 95% CI: 2.41-24.1; P = 0.0005) or who had a higher economic status in later life experienced a substantially elevated risk of hyperglycemia (odds ratios = 6.20; 95% CI: 2.08-18.5; P = 0.001). CONCLUSIONS: Fetal exposure to the severe Chinese famine increases the risk of hyperglycemia in adulthood. This association appears to be exacerbated by a nutritionally rich environment in later life. SN - 1939-327X UR - https://www.unboundmedicine.com/medline/citation/20622161/Exposure_to_the_Chinese_famine_in_early_life_and_the_risk_of_hyperglycemia_and_type_2_diabetes_in_adulthood_ L2 - http://diabetes.diabetesjournals.org/cgi/pmidlookup?view=long&pmid=20622161 DB - PRIME DP - Unbound Medicine ER -