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The overlap between neurodegenerative and vascular factors in the pathogenesis of dementia.
Acta Neuropathol 2010; 120(3):287-96AN

Abstract

There is increasing evidence that cerebrovascular dysfunction plays a role not only in vascular causes of cognitive impairment but also in Alzheimer's disease (AD). Vascular risk factors and AD impair the structure and function of cerebral blood vessels and associated cells (neurovascular unit), effects mediated by vascular oxidative stress and inflammation. Injury to the neurovascular unit alters cerebral blood flow regulation, depletes vascular reserves, disrupts the blood-brain barrier, and reduces the brain's repair potential, effects that amplify the brain dysfunction and damage exerted by incident ischemia and coexisting neurodegeneration. Clinical-pathological studies support the notion that vascular lesions aggravate the deleterious effects of AD pathology by reducing the threshold for cognitive impairment and accelerating the pace of the dementia. In the absence of mechanism-based approaches to counteract cognitive dysfunction, targeting vascular risk factors and improving cerebrovascular health offers the opportunity to mitigate the impact of one of the most disabling human afflictions.

Authors+Show Affiliations

Division of Neurobiology, Weill Cornell Medical College, New York, NY 10065, USA. coi2001@med.cornell.edu

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Review

Language

eng

PubMed ID

20623294

Citation

Iadecola, Costantino. "The Overlap Between Neurodegenerative and Vascular Factors in the Pathogenesis of Dementia." Acta Neuropathologica, vol. 120, no. 3, 2010, pp. 287-96.
Iadecola C. The overlap between neurodegenerative and vascular factors in the pathogenesis of dementia. Acta Neuropathol. 2010;120(3):287-96.
Iadecola, C. (2010). The overlap between neurodegenerative and vascular factors in the pathogenesis of dementia. Acta Neuropathologica, 120(3), pp. 287-96. doi:10.1007/s00401-010-0718-6.
Iadecola C. The Overlap Between Neurodegenerative and Vascular Factors in the Pathogenesis of Dementia. Acta Neuropathol. 2010;120(3):287-96. PubMed PMID: 20623294.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The overlap between neurodegenerative and vascular factors in the pathogenesis of dementia. A1 - Iadecola,Costantino, Y1 - 2010/07/11/ PY - 2010/06/28/received PY - 2010/07/04/accepted PY - 2010/07/03/revised PY - 2010/7/13/entrez PY - 2010/7/14/pubmed PY - 2010/11/16/medline SP - 287 EP - 96 JF - Acta neuropathologica JO - Acta Neuropathol. VL - 120 IS - 3 N2 - There is increasing evidence that cerebrovascular dysfunction plays a role not only in vascular causes of cognitive impairment but also in Alzheimer's disease (AD). Vascular risk factors and AD impair the structure and function of cerebral blood vessels and associated cells (neurovascular unit), effects mediated by vascular oxidative stress and inflammation. Injury to the neurovascular unit alters cerebral blood flow regulation, depletes vascular reserves, disrupts the blood-brain barrier, and reduces the brain's repair potential, effects that amplify the brain dysfunction and damage exerted by incident ischemia and coexisting neurodegeneration. Clinical-pathological studies support the notion that vascular lesions aggravate the deleterious effects of AD pathology by reducing the threshold for cognitive impairment and accelerating the pace of the dementia. In the absence of mechanism-based approaches to counteract cognitive dysfunction, targeting vascular risk factors and improving cerebrovascular health offers the opportunity to mitigate the impact of one of the most disabling human afflictions. SN - 1432-0533 UR - https://www.unboundmedicine.com/medline/citation/20623294/The_overlap_between_neurodegenerative_and_vascular_factors_in_the_pathogenesis_of_dementia_ L2 - https://dx.doi.org/10.1007/s00401-010-0718-6 DB - PRIME DP - Unbound Medicine ER -