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An intensive behavioral weight loss intervention and hot flushes in women.
Arch Intern Med. 2010 Jul 12; 170(13):1161-7.AI

Abstract

BACKGROUND

Higher body mass index is associated with worse hot flushes during menopause but the effect of weight loss on flushing is unclear.

METHODS

Self-administered questionnaires were used to assess bothersome hot flushes in a 6-month randomized controlled trial of an intensive behavioral weight loss program (intervention) vs a structured health education program (control) in 338 women who were overweight or obese and had urinary incontinence. Weight, body mass index, abdominal circumference, physical activity, calorie intake, blood pressure, and physical and mental functioning were assessed at baseline and at 6 months. Repeated-measures proportional odds models examined intervention effects on bothersome hot flushes and potential mediating factors.

RESULTS

Approximately half of participants (n = 154) were at least slightly bothered by hot flushes at baseline. Among these women, the intervention was associated with greater improvement in bothersome flushes vs control (odds ratio [OR] for improvement by 1 Likert category, 2.25; 95% confidence interval [CI], 1.20-4.21). Reductions in weight (OR, 1.32; 95% CI, 1.08-1.61; per 5-kg decrease), body mass index (1.17; 1.05-1.30; per 1-point decrease), and abdominal circumference (1.32; 1.07-1.64; per 5-cm decrease) were each associated with improvement in flushing, but changes in physical activity, calorie intake, blood pressure, and physical and mental functioning were not related. The effect of the intervention on flushing was modestly diminished after adjustment for multiple potential mediators (OR, 1.92; 95% CI, 0.95-3.89).

CONCLUSION

Among women who were overweight or obese and had bothersome hot flushes, an intensive behavioral weight loss intervention resulted in improvement in flushing relative to control. Trial Registration clinicaltrials.gov Identifier: NCT00091988.

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Authors+Show Affiliations

Huang AJ
Department of Medicine, University of California, San Francisco, San Francisco, CA 94115, USA. ahuang@ucsfmed.org
Subak LL
No affiliation info available
Wing R
No affiliation info available
West DS
No affiliation info available
Hernandez AL
No affiliation info available
Macer J
No affiliation info available
Grady D
No affiliation info available
Program to Reduce Incontinence by Diet and Exercise Investigators
No affiliation info available

MeSH

AlabamaBehavior TherapyBody Mass IndexFemaleFollow-Up StudiesHot FlashesHumansIncidenceMenopauseMiddle AgedObesityOverweightRhode IslandSurveys and QuestionnairesTreatment OutcomeWeight Loss

Pub Type(s)

Comparative Study
Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20625026

Clinical Trial Links

Clinical trial which this article describes

Citation

Huang, Alison J., et al. "An Intensive Behavioral Weight Loss Intervention and Hot Flushes in Women." Archives of Internal Medicine, vol. 170, no. 13, 2010, pp. 1161-7.
Huang AJ, Subak LL, Wing R, et al. An intensive behavioral weight loss intervention and hot flushes in women. Arch Intern Med. 2010;170(13):1161-7.
Huang, A. J., Subak, L. L., Wing, R., West, D. S., Hernandez, A. L., Macer, J., & Grady, D. (2010). An intensive behavioral weight loss intervention and hot flushes in women. Archives of Internal Medicine, 170(13), 1161-7. https://doi.org/10.1001/archinternmed.2010.162
Huang AJ, et al. An Intensive Behavioral Weight Loss Intervention and Hot Flushes in Women. Arch Intern Med. 2010 Jul 12;170(13):1161-7. PubMed PMID: 20625026.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - An intensive behavioral weight loss intervention and hot flushes in women. AU - Huang,Alison J, AU - Subak,Leslee L, AU - Wing,Rena, AU - West,Delia Smith, AU - Hernandez,Alexandra L, AU - Macer,Judy, AU - Grady,Deborah, AU - ,, PY - 2010/7/14/entrez PY - 2010/7/14/pubmed PY - 2010/9/3/medline SP - 1161 EP - 7 JF - Archives of internal medicine JO - Arch Intern Med VL - 170 IS - 13 N2 - BACKGROUND: Higher body mass index is associated with worse hot flushes during menopause but the effect of weight loss on flushing is unclear. METHODS: Self-administered questionnaires were used to assess bothersome hot flushes in a 6-month randomized controlled trial of an intensive behavioral weight loss program (intervention) vs a structured health education program (control) in 338 women who were overweight or obese and had urinary incontinence. Weight, body mass index, abdominal circumference, physical activity, calorie intake, blood pressure, and physical and mental functioning were assessed at baseline and at 6 months. Repeated-measures proportional odds models examined intervention effects on bothersome hot flushes and potential mediating factors. RESULTS: Approximately half of participants (n = 154) were at least slightly bothered by hot flushes at baseline. Among these women, the intervention was associated with greater improvement in bothersome flushes vs control (odds ratio [OR] for improvement by 1 Likert category, 2.25; 95% confidence interval [CI], 1.20-4.21). Reductions in weight (OR, 1.32; 95% CI, 1.08-1.61; per 5-kg decrease), body mass index (1.17; 1.05-1.30; per 1-point decrease), and abdominal circumference (1.32; 1.07-1.64; per 5-cm decrease) were each associated with improvement in flushing, but changes in physical activity, calorie intake, blood pressure, and physical and mental functioning were not related. The effect of the intervention on flushing was modestly diminished after adjustment for multiple potential mediators (OR, 1.92; 95% CI, 0.95-3.89). CONCLUSION: Among women who were overweight or obese and had bothersome hot flushes, an intensive behavioral weight loss intervention resulted in improvement in flushing relative to control. Trial Registration clinicaltrials.gov Identifier: NCT00091988. SN - 1538-3679 UR - https://www.unboundmedicine.com/medline/citation/20625026/full_citation L2 - https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/10.1001/archinternmed.2010.162 DB - PRIME DP - Unbound Medicine ER -