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Serum vitamin D and the risk of Parkinson disease.
Arch Neurol. 2010 Jul; 67(7):808-11.AN

Abstract

OBJECTIVE

To investigate whether serum vitamin D level predicts the risk of Parkinson disease.

DESIGN

Cohort study.

SETTING

The study was based on the Mini-Finland Health Survey, which was conducted from 1978 to 1980, with Parkinson disease occurrence follow-up through the end of 2007. During the 29-year follow-up period, 50 incident Parkinson disease cases occurred. Serum 25-hydroxyvitamin D level was determined from frozen samples stored at baseline. Estimates of the relationship between serum vitamin D concentration and Parkinson disease incidence were calculated using the Cox model.

PARTICIPANTS

Three thousand one hundred seventy-three men and women, aged 50 to 79 years and free of Parkinson disease at baseline. Main Outcome Measure Parkinson disease incidence.

RESULTS

Individuals with higher serum vitamin D concentrations showed a reduced risk of Parkinson disease. The relative risk between the highest and lowest quartiles was 0.33 (95% confidence interval, 0.14-0.80) after adjustment for sex, age, marital status, education, alcohol consumption, leisure-time physical activity, smoking, body mass index, and month of blood draw.

CONCLUSIONS

The results are consistent with the suggestion that high vitamin D status provides protection against Parkinson disease. It cannot, however, be excluded that the finding is due to residual confounding and further studies are thus needed.

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Authors+Show Affiliations

Knekt P
National Institute for Health and Welfare, Helsinki, Finland. paul.knekt@thl.fi
Kilkkinen A
No affiliation info available
Rissanen H
No affiliation info available
Marniemi J
No affiliation info available
Sääksjärvi K
No affiliation info available
Heliövaara M
No affiliation info available

MeSH

AgedFemaleFinlandHealth SurveysHumansIncidenceLongitudinal StudiesMaleMiddle AgedParkinson DiseaseProportional Hazards ModelsVitamin D

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

20625085

Citation

Knekt, Paul, et al. "Serum Vitamin D and the Risk of Parkinson Disease." Archives of Neurology, vol. 67, no. 7, 2010, pp. 808-11.
Knekt P, Kilkkinen A, Rissanen H, et al. Serum vitamin D and the risk of Parkinson disease. Arch Neurol. 2010;67(7):808-11.
Knekt, P., Kilkkinen, A., Rissanen, H., Marniemi, J., Sääksjärvi, K., & Heliövaara, M. (2010). Serum vitamin D and the risk of Parkinson disease. Archives of Neurology, 67(7), 808-11. https://doi.org/10.1001/archneurol.2010.120
Knekt P, et al. Serum Vitamin D and the Risk of Parkinson Disease. Arch Neurol. 2010;67(7):808-11. PubMed PMID: 20625085.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum vitamin D and the risk of Parkinson disease. AU - Knekt,Paul, AU - Kilkkinen,Annamari, AU - Rissanen,Harri, AU - Marniemi,Jukka, AU - Sääksjärvi,Katri, AU - Heliövaara,Markku, PY - 2010/7/14/entrez PY - 2010/7/14/pubmed PY - 2010/8/7/medline SP - 808 EP - 11 JF - Archives of neurology JO - Arch Neurol VL - 67 IS - 7 N2 - OBJECTIVE: To investigate whether serum vitamin D level predicts the risk of Parkinson disease. DESIGN: Cohort study. SETTING: The study was based on the Mini-Finland Health Survey, which was conducted from 1978 to 1980, with Parkinson disease occurrence follow-up through the end of 2007. During the 29-year follow-up period, 50 incident Parkinson disease cases occurred. Serum 25-hydroxyvitamin D level was determined from frozen samples stored at baseline. Estimates of the relationship between serum vitamin D concentration and Parkinson disease incidence were calculated using the Cox model. PARTICIPANTS: Three thousand one hundred seventy-three men and women, aged 50 to 79 years and free of Parkinson disease at baseline. Main Outcome Measure Parkinson disease incidence. RESULTS: Individuals with higher serum vitamin D concentrations showed a reduced risk of Parkinson disease. The relative risk between the highest and lowest quartiles was 0.33 (95% confidence interval, 0.14-0.80) after adjustment for sex, age, marital status, education, alcohol consumption, leisure-time physical activity, smoking, body mass index, and month of blood draw. CONCLUSIONS: The results are consistent with the suggestion that high vitamin D status provides protection against Parkinson disease. It cannot, however, be excluded that the finding is due to residual confounding and further studies are thus needed. SN - 1538-3687 UR - https://www.unboundmedicine.com/medline/citation/20625085/full_citation L2 - https://jamanetwork.com/journals/jamaneurology/fullarticle/10.1001/archneurol.2010.120 DB - PRIME DP - Unbound Medicine ER -