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Serum vitamin D and the risk of Parkinson disease.

Abstract

OBJECTIVE

To investigate whether serum vitamin D level predicts the risk of Parkinson disease.

DESIGN

Cohort study.

SETTING

The study was based on the Mini-Finland Health Survey, which was conducted from 1978 to 1980, with Parkinson disease occurrence follow-up through the end of 2007. During the 29-year follow-up period, 50 incident Parkinson disease cases occurred. Serum 25-hydroxyvitamin D level was determined from frozen samples stored at baseline. Estimates of the relationship between serum vitamin D concentration and Parkinson disease incidence were calculated using the Cox model.

PARTICIPANTS

Three thousand one hundred seventy-three men and women, aged 50 to 79 years and free of Parkinson disease at baseline. Main Outcome Measure Parkinson disease incidence.

RESULTS

Individuals with higher serum vitamin D concentrations showed a reduced risk of Parkinson disease. The relative risk between the highest and lowest quartiles was 0.33 (95% confidence interval, 0.14-0.80) after adjustment for sex, age, marital status, education, alcohol consumption, leisure-time physical activity, smoking, body mass index, and month of blood draw.

CONCLUSIONS

The results are consistent with the suggestion that high vitamin D status provides protection against Parkinson disease. It cannot, however, be excluded that the finding is due to residual confounding and further studies are thus needed.

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    Source

    Archives of neurology 67:7 2010 Jul pg 808-11

    MeSH

    Aged
    Female
    Finland
    Health Surveys
    Humans
    Incidence
    Longitudinal Studies
    Male
    Middle Aged
    Parkinson Disease
    Proportional Hazards Models
    Vitamin D

    Pub Type(s)

    Journal Article
    Research Support, N.I.H., Extramural

    Language

    eng

    PubMed ID

    20625085

    Citation

    TY - JOUR T1 - Serum vitamin D and the risk of Parkinson disease. AU - Knekt,Paul, AU - Kilkkinen,Annamari, AU - Rissanen,Harri, AU - Marniemi,Jukka, AU - Sääksjärvi,Katri, AU - Heliövaara,Markku, PY - 2010/7/14/entrez PY - 2010/7/14/pubmed PY - 2010/8/7/medline SP - 808 EP - 11 JF - Archives of neurology JO - Arch. Neurol. VL - 67 IS - 7 N2 - OBJECTIVE: To investigate whether serum vitamin D level predicts the risk of Parkinson disease. DESIGN: Cohort study. SETTING: The study was based on the Mini-Finland Health Survey, which was conducted from 1978 to 1980, with Parkinson disease occurrence follow-up through the end of 2007. During the 29-year follow-up period, 50 incident Parkinson disease cases occurred. Serum 25-hydroxyvitamin D level was determined from frozen samples stored at baseline. Estimates of the relationship between serum vitamin D concentration and Parkinson disease incidence were calculated using the Cox model. PARTICIPANTS: Three thousand one hundred seventy-three men and women, aged 50 to 79 years and free of Parkinson disease at baseline. Main Outcome Measure Parkinson disease incidence. RESULTS: Individuals with higher serum vitamin D concentrations showed a reduced risk of Parkinson disease. The relative risk between the highest and lowest quartiles was 0.33 (95% confidence interval, 0.14-0.80) after adjustment for sex, age, marital status, education, alcohol consumption, leisure-time physical activity, smoking, body mass index, and month of blood draw. CONCLUSIONS: The results are consistent with the suggestion that high vitamin D status provides protection against Parkinson disease. It cannot, however, be excluded that the finding is due to residual confounding and further studies are thus needed. SN - 1538-3687 UR - https://www.unboundmedicine.com/medline/citation/20625085/full_citation L2 - http://archneur.jamanetwork.com/article.aspx?doi=10.1001/archneurol.2010.120 ER -