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Virosomal influenza-vaccine induced immunity in HIV-infected individuals with high versus low CD4+ T-cell counts: clues towards a rational vaccination strategy.
AIDS. 2010 Sep 10; 24(14):2287-9.AIDS

Abstract

In a prospective influenza-vaccination trial we show that HIV-infected individuals with CD4 T-cell counts less than 350 microl were distinct from HIV-infected individuals with more than 350 CD4 T-cell counts/microl, and from HIV-negative individuals, in that an influenza-specific immunoglobulin M-response was absent and expansion of interferon-gamma-secreting CD4 T cells was impaired. By contrast, immunoglobulin G-responses were induced in all study groups. These data suggest that establishing broad influenza-specific (immunoglobulin G) B-cell memory prior to severe immunodeficiency is important.

Authors+Show Affiliations

Department of Biomedicine, Basel University, Switzerland.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20625265

Citation

Fritz, Stefanie, et al. "Virosomal Influenza-vaccine Induced Immunity in HIV-infected Individuals With High Versus Low CD4+ T-cell Counts: Clues Towards a Rational Vaccination Strategy." AIDS (London, England), vol. 24, no. 14, 2010, pp. 2287-9.
Fritz S, Mossdorf E, Durovic B, et al. Virosomal influenza-vaccine induced immunity in HIV-infected individuals with high versus low CD4+ T-cell counts: clues towards a rational vaccination strategy. AIDS. 2010;24(14):2287-9.
Fritz, S., Mossdorf, E., Durovic, B., Zenhaeusern, G., Conen, A., Steffen, I., Battegay, M., Nüesch, R., & Hess, C. (2010). Virosomal influenza-vaccine induced immunity in HIV-infected individuals with high versus low CD4+ T-cell counts: clues towards a rational vaccination strategy. AIDS (London, England), 24(14), 2287-9. https://doi.org/10.1097/QAD.0b013e32833c6f92
Fritz S, et al. Virosomal Influenza-vaccine Induced Immunity in HIV-infected Individuals With High Versus Low CD4+ T-cell Counts: Clues Towards a Rational Vaccination Strategy. AIDS. 2010 Sep 10;24(14):2287-9. PubMed PMID: 20625265.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Virosomal influenza-vaccine induced immunity in HIV-infected individuals with high versus low CD4+ T-cell counts: clues towards a rational vaccination strategy. AU - Fritz,Stefanie, AU - Mossdorf,Erik, AU - Durovic,Bojana, AU - Zenhaeusern,Gabriela, AU - Conen,Anna, AU - Steffen,Ingrid, AU - Battegay,Manuel, AU - Nüesch,Reto, AU - Hess,Christoph, PY - 2010/7/14/entrez PY - 2010/7/14/pubmed PY - 2011/3/26/medline SP - 2287 EP - 9 JF - AIDS (London, England) JO - AIDS VL - 24 IS - 14 N2 - In a prospective influenza-vaccination trial we show that HIV-infected individuals with CD4 T-cell counts less than 350 microl were distinct from HIV-infected individuals with more than 350 CD4 T-cell counts/microl, and from HIV-negative individuals, in that an influenza-specific immunoglobulin M-response was absent and expansion of interferon-gamma-secreting CD4 T cells was impaired. By contrast, immunoglobulin G-responses were induced in all study groups. These data suggest that establishing broad influenza-specific (immunoglobulin G) B-cell memory prior to severe immunodeficiency is important. SN - 1473-5571 UR - https://www.unboundmedicine.com/medline/citation/20625265/Virosomal_influenza_vaccine_induced_immunity_in_HIV_infected_individuals_with_high_versus_low_CD4+_T_cell_counts:_clues_towards_a_rational_vaccination_strategy_ L2 - http://Insights.ovid.com/pubmed?pmid=20625265 DB - PRIME DP - Unbound Medicine ER -