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Genetics of menstrual migraine: the molecular evidence.
Curr Pain Headache Rep. 2010 Oct; 14(5):389-95.CP

Abstract

Migraine is considered to be a multifactorial disorder in which genetic, environmental, and, in the case of menstrual and menstrually related migraine, hormonal events influence the phenotype. Certainly, the role of female sex hormones in migraine has been well established, yet the mechanism behind this well-known relationship remains unclear. This review focuses on the potential role of hormonally related genes in migraine, summarizes results of candidate gene studies to date, and discusses challenges and issues involved in interpreting hormone-related gene results. In light of the molecular evidence presented, we discuss future approaches for analysis with the view to elucidate the complex genetic architecture that underlies the disorder.

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Authors+Show Affiliations

Colson N
Genomics Research Centre, Griffith Health Institute, School of Medical Science, Griffith University, Gold Coast, Queensland, 4222, Australia.
Fernandez F
No affiliation info available
Griffiths L
No affiliation info available

MeSH

Evidence-Based MedicineFemaleGenetic Predisposition to DiseaseGonadal Steroid HormonesHumansMenstrual CycleMigraine DisordersPremenstrual SyndromeRisk Reduction Behavior

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

20625856

Citation

Colson, Natalie, et al. "Genetics of Menstrual Migraine: the Molecular Evidence." Current Pain and Headache Reports, vol. 14, no. 5, 2010, pp. 389-95.
Colson N, Fernandez F, Griffiths L. Genetics of menstrual migraine: the molecular evidence. Curr Pain Headache Rep. 2010;14(5):389-95.
Colson, N., Fernandez, F., & Griffiths, L. (2010). Genetics of menstrual migraine: the molecular evidence. Current Pain and Headache Reports, 14(5), 389-95. https://doi.org/10.1007/s11916-010-0129-3
Colson N, Fernandez F, Griffiths L. Genetics of Menstrual Migraine: the Molecular Evidence. Curr Pain Headache Rep. 2010;14(5):389-95. PubMed PMID: 20625856.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Genetics of menstrual migraine: the molecular evidence. AU - Colson,Natalie, AU - Fernandez,Francesca, AU - Griffiths,Lyn, PY - 2010/7/14/entrez PY - 2010/7/14/pubmed PY - 2011/8/4/medline SP - 389 EP - 95 JF - Current pain and headache reports JO - Curr Pain Headache Rep VL - 14 IS - 5 N2 - Migraine is considered to be a multifactorial disorder in which genetic, environmental, and, in the case of menstrual and menstrually related migraine, hormonal events influence the phenotype. Certainly, the role of female sex hormones in migraine has been well established, yet the mechanism behind this well-known relationship remains unclear. This review focuses on the potential role of hormonally related genes in migraine, summarizes results of candidate gene studies to date, and discusses challenges and issues involved in interpreting hormone-related gene results. In light of the molecular evidence presented, we discuss future approaches for analysis with the view to elucidate the complex genetic architecture that underlies the disorder. SN - 1534-3081 UR - https://www.unboundmedicine.com/medline/citation/20625856/Genetics_of_menstrual_migraine:_the_molecular_evidence_ L2 - https://dx.doi.org/10.1007/s11916-010-0129-3 DB - PRIME DP - Unbound Medicine ER -