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Recent patents and trends in orally disintegrating tablets.
Recent Pat Drug Deliv Formul. 2010 Nov; 4(3):178-97.RP

Abstract

Orally disintegrating tablets (ODTs) offer many advantages over the conventional oral dosage forms in terms of convenience and ease of use. Over the last decade, substantial advances in the formulation of ODTs have been achieved in academia and industry that resulted in the emerging of a large number of patents. The aim of this review is to summarise the most recent patents in ODT formulations and highlight their motivations, inventive steps and significances in the development of ODT formulations. Five major techniques have been applied in manufacturing of ODTs, namely conventional tablet press, moulding, freeze drying, tablet loading and pulverization, with majority of the patents dedicated to the use of conventional tablet pressing. The patents have addressed various issues concerning the manufacturing of robust and practical ODT formulations by disclosing new manufacturing techniques, advantageous materials, and innovative formulation steps. However, future developments are required to reduce the cost and widening the application of the new manufacturing techniques, while simplifying and shortening the formulation steps will be crucial in the well established ones.

Authors+Show Affiliations

Aston Pharmacy School, Aston University, Birmingham B4 7ET, UK.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

20626334

Citation

AlHusban, Farhan A., et al. "Recent Patents and Trends in Orally Disintegrating Tablets." Recent Patents On Drug Delivery & Formulation, vol. 4, no. 3, 2010, pp. 178-97.
AlHusban FA, El-Shaer AM, Jones RJ, et al. Recent patents and trends in orally disintegrating tablets. Recent Pat Drug Deliv Formul. 2010;4(3):178-97.
AlHusban, F. A., El-Shaer, A. M., Jones, R. J., & Mohammed, A. R. (2010). Recent patents and trends in orally disintegrating tablets. Recent Patents On Drug Delivery & Formulation, 4(3), 178-97.
AlHusban FA, et al. Recent Patents and Trends in Orally Disintegrating Tablets. Recent Pat Drug Deliv Formul. 2010;4(3):178-97. PubMed PMID: 20626334.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Recent patents and trends in orally disintegrating tablets. AU - AlHusban,Farhan A, AU - El-Shaer,Amr M, AU - Jones,Rhys J, AU - Mohammed,Afzal R, PY - 2010/04/02/received PY - 2010/05/20/accepted PY - 2010/7/15/entrez PY - 2010/7/16/pubmed PY - 2011/2/5/medline SP - 178 EP - 97 JF - Recent patents on drug delivery & formulation JO - Recent Pat Drug Deliv Formul VL - 4 IS - 3 N2 - Orally disintegrating tablets (ODTs) offer many advantages over the conventional oral dosage forms in terms of convenience and ease of use. Over the last decade, substantial advances in the formulation of ODTs have been achieved in academia and industry that resulted in the emerging of a large number of patents. The aim of this review is to summarise the most recent patents in ODT formulations and highlight their motivations, inventive steps and significances in the development of ODT formulations. Five major techniques have been applied in manufacturing of ODTs, namely conventional tablet press, moulding, freeze drying, tablet loading and pulverization, with majority of the patents dedicated to the use of conventional tablet pressing. The patents have addressed various issues concerning the manufacturing of robust and practical ODT formulations by disclosing new manufacturing techniques, advantageous materials, and innovative formulation steps. However, future developments are required to reduce the cost and widening the application of the new manufacturing techniques, while simplifying and shortening the formulation steps will be crucial in the well established ones. SN - 2212-4039 UR - https://www.unboundmedicine.com/medline/citation/20626334/Recent_patents_and_trends_in_orally_disintegrating_tablets_ L2 - http://www.eurekaselect.com/94093/article DB - PRIME DP - Unbound Medicine ER -