Tags

Type your tag names separated by a space and hit enter

Esophageal verrucous carcinoma arising from hyperkeratotic plaques associated with human papilloma virus type 51.
Dis Esophagus. 2010 Jul; 23(5):E17-20.DE

Abstract

Esophageal verrucous carcinoma is a rare variant of esophageal squamous cell carcinoma. We report a case of esophageal verrucous carcinoma associated with human papilloma virus (HPV) type 51. The patient had long-standing dysphagia and odynophagia, and white esophageal plaques showing hyperkeratosis on biopsy. At repeat endoscopy, the esophagus was covered with verrucous white plaques and areas of nodular mucosa with white fronds, with a distal 10-cm smooth mass protruding into the lumen. Biopsies demonstrated an atypical squamoproliferative lesion but no frank malignancy. HPV type 51 DNA was detected in endoscopic biopsy specimens by polymerase chain reaction. Because the size of the lesion favored an underlying verrucous carcinoma, our patient underwent minimally invasive esophagectomy with gastric pull-up and cervical anastomosis. The pathologic diagnosis was a well-differentiated esophageal verrucous carcinoma. One year after esophagectomy, the patient feels well and is free of disease. Although HPV DNA was not detected in the cancer tissue obtained at surgery, our case suggests an association between HPV type 51 and esophageal verrucous carcinoma. The clinical evolution in this case highlights the importance of endoscopic surveillance in patients with exuberant esophageal hyperkeratosis, and of definitive surgical resection when malignancy is suspected even if frank malignancy is not demonstrated on superficial biopsies.

Authors+Show Affiliations

School of Medicine, University of California, San Francisco, California, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

20626449

Citation

Tonna, J, et al. "Esophageal Verrucous Carcinoma Arising From Hyperkeratotic Plaques Associated With Human Papilloma Virus Type 51." Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus, vol. 23, no. 5, 2010, pp. E17-20.
Tonna J, Palefsky JM, Rabban J, et al. Esophageal verrucous carcinoma arising from hyperkeratotic plaques associated with human papilloma virus type 51. Dis Esophagus. 2010;23(5):E17-20.
Tonna, J., Palefsky, J. M., Rabban, J., Campos, G. M., Theodore, P., & Ladabaum, U. (2010). Esophageal verrucous carcinoma arising from hyperkeratotic plaques associated with human papilloma virus type 51. Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus, 23(5), E17-20. https://doi.org/10.1111/j.1442-2050.2010.01087.x
Tonna J, et al. Esophageal Verrucous Carcinoma Arising From Hyperkeratotic Plaques Associated With Human Papilloma Virus Type 51. Dis Esophagus. 2010;23(5):E17-20. PubMed PMID: 20626449.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Esophageal verrucous carcinoma arising from hyperkeratotic plaques associated with human papilloma virus type 51. AU - Tonna,J, AU - Palefsky,J M, AU - Rabban,J, AU - Campos,G M, AU - Theodore,P, AU - Ladabaum,U, Y1 - 2010/07/08/ PY - 2010/7/15/entrez PY - 2010/7/16/pubmed PY - 2010/11/3/medline SP - E17 EP - 20 JF - Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus JO - Dis. Esophagus VL - 23 IS - 5 N2 - Esophageal verrucous carcinoma is a rare variant of esophageal squamous cell carcinoma. We report a case of esophageal verrucous carcinoma associated with human papilloma virus (HPV) type 51. The patient had long-standing dysphagia and odynophagia, and white esophageal plaques showing hyperkeratosis on biopsy. At repeat endoscopy, the esophagus was covered with verrucous white plaques and areas of nodular mucosa with white fronds, with a distal 10-cm smooth mass protruding into the lumen. Biopsies demonstrated an atypical squamoproliferative lesion but no frank malignancy. HPV type 51 DNA was detected in endoscopic biopsy specimens by polymerase chain reaction. Because the size of the lesion favored an underlying verrucous carcinoma, our patient underwent minimally invasive esophagectomy with gastric pull-up and cervical anastomosis. The pathologic diagnosis was a well-differentiated esophageal verrucous carcinoma. One year after esophagectomy, the patient feels well and is free of disease. Although HPV DNA was not detected in the cancer tissue obtained at surgery, our case suggests an association between HPV type 51 and esophageal verrucous carcinoma. The clinical evolution in this case highlights the importance of endoscopic surveillance in patients with exuberant esophageal hyperkeratosis, and of definitive surgical resection when malignancy is suspected even if frank malignancy is not demonstrated on superficial biopsies. SN - 1442-2050 UR - https://www.unboundmedicine.com/medline/citation/20626449/Esophageal_verrucous_carcinoma_arising_from_hyperkeratotic_plaques_associated_with_human_papilloma_virus_type_51_ L2 - https://academic.oup.com/dote/article-lookup/doi/10.1111/j.1442-2050.2010.01087.x DB - PRIME DP - Unbound Medicine ER -