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Synthesis and biological evaluation of indolyl chalcones as antitumor agents.
Bioorg Med Chem Lett. 2010 Jul 01; 20(13):3916-9.BM

Abstract

A series of indolyl chalcones were synthesized and evaluated in vitro for their anticancer activity against three human cancer cell lines. Compounds 3b-d, 3h, 3j, 3l, 3m, 4g, and 4j showed significant cytotoxicity, particularly, indolyl chalcones 3l and 3m were identified as the most potent and selective anticancer agents with IC(50) values 0.03 and 0.09 microM, against PaCa-2 cell line, respectively.

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Authors+Show Affiliations

Kumar D
Birla Institute of Technology and Science, Pilani, India. dalipk@bits-pilani.ac.in
Kumar NM
No affiliation info available
Akamatsu K
No affiliation info available
Kusaka E
No affiliation info available
Harada H
No affiliation info available
Ito T
No affiliation info available

MeSH

Antineoplastic AgentsCell Line, TumorCell ProliferationChalconesDose-Response Relationship, DrugDrug Screening Assays, AntitumorHumansMolecular StructureStereoisomerismStructure-Activity Relationship

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20627724

Citation

Kumar, Dalip, et al. "Synthesis and Biological Evaluation of Indolyl Chalcones as Antitumor Agents." Bioorganic & Medicinal Chemistry Letters, vol. 20, no. 13, 2010, pp. 3916-9.
Kumar D, Kumar NM, Akamatsu K, et al. Synthesis and biological evaluation of indolyl chalcones as antitumor agents. Bioorg Med Chem Lett. 2010;20(13):3916-9.
Kumar, D., Kumar, N. M., Akamatsu, K., Kusaka, E., Harada, H., & Ito, T. (2010). Synthesis and biological evaluation of indolyl chalcones as antitumor agents. Bioorganic & Medicinal Chemistry Letters, 20(13), 3916-9. https://doi.org/10.1016/j.bmcl.2010.05.016
Kumar D, et al. Synthesis and Biological Evaluation of Indolyl Chalcones as Antitumor Agents. Bioorg Med Chem Lett. 2010 Jul 1;20(13):3916-9. PubMed PMID: 20627724.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Synthesis and biological evaluation of indolyl chalcones as antitumor agents. AU - Kumar,Dalip, AU - Kumar,N Maruthi, AU - Akamatsu,Kanako, AU - Kusaka,Eriko, AU - Harada,Hiroshi, AU - Ito,Takeo, Y1 - 2010/05/13/ PY - 2009/12/18/received PY - 2010/03/02/revised PY - 2010/05/08/accepted PY - 2010/7/15/entrez PY - 2010/7/16/pubmed PY - 2011/1/14/medline SP - 3916 EP - 9 JF - Bioorganic & medicinal chemistry letters JO - Bioorg Med Chem Lett VL - 20 IS - 13 N2 - A series of indolyl chalcones were synthesized and evaluated in vitro for their anticancer activity against three human cancer cell lines. Compounds 3b-d, 3h, 3j, 3l, 3m, 4g, and 4j showed significant cytotoxicity, particularly, indolyl chalcones 3l and 3m were identified as the most potent and selective anticancer agents with IC(50) values 0.03 and 0.09 microM, against PaCa-2 cell line, respectively. SN - 1464-3405 UR - https://www.unboundmedicine.com/medline/citation/20627724/Synthesis_and_biological_evaluation_of_indolyl_chalcones_as_antitumor_agents_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0960-894X(10)00657-8 DB - PRIME DP - Unbound Medicine ER -