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Comparison of waist-to-hip ratio and other obesity indices as predictors of cardiovascular disease risk in people with type-2 diabetes: a prospective cohort study from ADVANCE.
Eur J Cardiovasc Prev Rehabil. 2011 Apr; 18(2):312-9.EJ

Abstract

AIMS

The aim of this study was to compare the strength of associations and discrimination capability of body mass index (BMI), waist circumference (WC) and waist-to-hip ratio (WHR) with cardiovascular disease risk in individuals with type-2 diabetes.

METHODS AND RESULTS

Eleven thousand, one hundred and forty men and women were followed for a mean of 4.8 years. The Cox proportional hazard models were used to compute the hazard ratios and 95% confidence intervals (95% CI) for one standard deviation (SD) increase in baseline BMI (SD: 5 kg/m2), WC (SD: 13 cm) and WHR (SD: 0.08) with cardiovascular disease risk. After adjustment, hazard ratio (95% CI) for WC were 1.10 (1.03–1.18) for cardiovascular events, 1.13 (1.03–1.24) for coronary events, and 1.08 (0.98–1.19) for cardiovascular deaths. Estimates for WHR were 1.12 (1.05–1.19), 1.17 (1.08–1.28) and 1.19 (1.09–1.31). BMI was not related to any of these outcomes. Although the receiver operating characteristic curve could not differentiate between anthropometric variables (P values 0.24), the relative integrated discrimination improvement statistic showed an enhancement in the discrimination capabilities of models using WHR for cardiovascular outcomes, except for cerebrovascular events.

CONCLUSION

Strengths of associations and discrimination statistics suggested that WHR was the best predictor of cardiovascular events and mortality in patients with type-2 diabetes and BMI the worst.

Authors+Show Affiliations

The George Institute for International Health, The University of Sydney, New South Wales, Australia. czernichow@uren.smbh.univ-paris13.frNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20628304

Citation

Czernichow, Sébastien, et al. "Comparison of Waist-to-hip Ratio and Other Obesity Indices as Predictors of Cardiovascular Disease Risk in People With Type-2 Diabetes: a Prospective Cohort Study From ADVANCE." European Journal of Cardiovascular Prevention and Rehabilitation : Official Journal of the European Society of Cardiology, Working Groups On Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology, vol. 18, no. 2, 2011, pp. 312-9.
Czernichow S, Kengne AP, Huxley RR, et al. Comparison of waist-to-hip ratio and other obesity indices as predictors of cardiovascular disease risk in people with type-2 diabetes: a prospective cohort study from ADVANCE. Eur J Cardiovasc Prev Rehabil. 2011;18(2):312-9.
Czernichow, S., Kengne, A. P., Huxley, R. R., Batty, G. D., de Galan, B., Grobbee, D., Pillai, A., Zoungas, S., Marre, M., Woodward, M., Neal, B., & Chalmers, J. (2011). Comparison of waist-to-hip ratio and other obesity indices as predictors of cardiovascular disease risk in people with type-2 diabetes: a prospective cohort study from ADVANCE. European Journal of Cardiovascular Prevention and Rehabilitation : Official Journal of the European Society of Cardiology, Working Groups On Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology, 18(2), 312-9. https://doi.org/10.1097/HJR.0b013e32833c1aa3
Czernichow S, et al. Comparison of Waist-to-hip Ratio and Other Obesity Indices as Predictors of Cardiovascular Disease Risk in People With Type-2 Diabetes: a Prospective Cohort Study From ADVANCE. Eur J Cardiovasc Prev Rehabil. 2011;18(2):312-9. PubMed PMID: 20628304.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparison of waist-to-hip ratio and other obesity indices as predictors of cardiovascular disease risk in people with type-2 diabetes: a prospective cohort study from ADVANCE. AU - Czernichow,Sébastien, AU - Kengne,Andre-Pascal, AU - Huxley,Rachel R, AU - Batty,George David, AU - de Galan,Bastiaan, AU - Grobbee,Diederick, AU - Pillai,Avinesh, AU - Zoungas,Sophia, AU - Marre,Michel, AU - Woodward,Mark, AU - Neal,Bruce, AU - Chalmers,John, AU - ,, PY - 2010/7/15/entrez PY - 2010/7/16/pubmed PY - 2011/7/19/medline SP - 312 EP - 9 JF - European journal of cardiovascular prevention and rehabilitation : official journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology JO - Eur J Cardiovasc Prev Rehabil VL - 18 IS - 2 N2 - AIMS: The aim of this study was to compare the strength of associations and discrimination capability of body mass index (BMI), waist circumference (WC) and waist-to-hip ratio (WHR) with cardiovascular disease risk in individuals with type-2 diabetes. METHODS AND RESULTS: Eleven thousand, one hundred and forty men and women were followed for a mean of 4.8 years. The Cox proportional hazard models were used to compute the hazard ratios and 95% confidence intervals (95% CI) for one standard deviation (SD) increase in baseline BMI (SD: 5 kg/m2), WC (SD: 13 cm) and WHR (SD: 0.08) with cardiovascular disease risk. After adjustment, hazard ratio (95% CI) for WC were 1.10 (1.03–1.18) for cardiovascular events, 1.13 (1.03–1.24) for coronary events, and 1.08 (0.98–1.19) for cardiovascular deaths. Estimates for WHR were 1.12 (1.05–1.19), 1.17 (1.08–1.28) and 1.19 (1.09–1.31). BMI was not related to any of these outcomes. Although the receiver operating characteristic curve could not differentiate between anthropometric variables (P values 0.24), the relative integrated discrimination improvement statistic showed an enhancement in the discrimination capabilities of models using WHR for cardiovascular outcomes, except for cerebrovascular events. CONCLUSION: Strengths of associations and discrimination statistics suggested that WHR was the best predictor of cardiovascular events and mortality in patients with type-2 diabetes and BMI the worst. SN - 1741-8275 UR - https://www.unboundmedicine.com/medline/citation/20628304/Comparison_of_waist_to_hip_ratio_and_other_obesity_indices_as_predictors_of_cardiovascular_disease_risk_in_people_with_type_2_diabetes:_a_prospective_cohort_study_from_ADVANCE_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20628304/ DB - PRIME DP - Unbound Medicine ER -