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REM sleep behavior disorder is not linked to postural instability and gait dysfunction in Parkinson.
Mov Disord. 2010 Aug 15; 25(11):1597-604.MD

Abstract

To evaluate a potential association of REM-sleep behavior disorder (RBD) with gait and postural impairment in Parkinson's disease (PD). Gait difficulties and postural impairment are frequent in PD and are a major cause of disability. Animal studies indicate a key role of the pedunculopontine nucleus (PPN) in gait, postural control, and REM sleep, and also in the pathophysiology of RBD. In humans, such an association has not been investigated. Twenty-six patients with mild-to-moderate PD (13 with polysomnography confirmed and 13 with excluded RBD), and 20 age-matched healthy controls were prospectively investigated. Gait assessment on a treadmill, and static and dynamic posturography were performed. PD patients with RBD do not differ from those without RBD in gait and postural control. Greater severity of PD or prevalence of gait and postural disturbances in the presence of RBD were not found. RBD was not associated with any particular motor phenotype. We found no association of RBD with gait disturbances and postural impairment. Human gait and postural control and RBD appear to depend upon different neuronal circuits.

Authors+Show Affiliations

Department of Neurology, University Hospital of Zurich, Zurich, Switzerland. benningerd@ninds.nih.govNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

20629146

Citation

Benninger, David H., et al. "REM Sleep Behavior Disorder Is Not Linked to Postural Instability and Gait Dysfunction in Parkinson." Movement Disorders : Official Journal of the Movement Disorder Society, vol. 25, no. 11, 2010, pp. 1597-604.
Benninger DH, Michel J, Waldvogel D, et al. REM sleep behavior disorder is not linked to postural instability and gait dysfunction in Parkinson. Mov Disord. 2010;25(11):1597-604.
Benninger, D. H., Michel, J., Waldvogel, D., Candia, V., Poryazova, R., van Hedel, H. J., & Bassetti, C. L. (2010). REM sleep behavior disorder is not linked to postural instability and gait dysfunction in Parkinson. Movement Disorders : Official Journal of the Movement Disorder Society, 25(11), 1597-604. https://doi.org/10.1002/mds.23121
Benninger DH, et al. REM Sleep Behavior Disorder Is Not Linked to Postural Instability and Gait Dysfunction in Parkinson. Mov Disord. 2010 Aug 15;25(11):1597-604. PubMed PMID: 20629146.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - REM sleep behavior disorder is not linked to postural instability and gait dysfunction in Parkinson. AU - Benninger,David H, AU - Michel,Jan, AU - Waldvogel,Daniel, AU - Candia,Victor, AU - Poryazova,Rositsa, AU - van Hedel,Hubertus J A, AU - Bassetti,Claudio L, PY - 2010/7/15/entrez PY - 2010/7/16/pubmed PY - 2010/12/14/medline SP - 1597 EP - 604 JF - Movement disorders : official journal of the Movement Disorder Society JO - Mov Disord VL - 25 IS - 11 N2 - To evaluate a potential association of REM-sleep behavior disorder (RBD) with gait and postural impairment in Parkinson's disease (PD). Gait difficulties and postural impairment are frequent in PD and are a major cause of disability. Animal studies indicate a key role of the pedunculopontine nucleus (PPN) in gait, postural control, and REM sleep, and also in the pathophysiology of RBD. In humans, such an association has not been investigated. Twenty-six patients with mild-to-moderate PD (13 with polysomnography confirmed and 13 with excluded RBD), and 20 age-matched healthy controls were prospectively investigated. Gait assessment on a treadmill, and static and dynamic posturography were performed. PD patients with RBD do not differ from those without RBD in gait and postural control. Greater severity of PD or prevalence of gait and postural disturbances in the presence of RBD were not found. RBD was not associated with any particular motor phenotype. We found no association of RBD with gait disturbances and postural impairment. Human gait and postural control and RBD appear to depend upon different neuronal circuits. SN - 1531-8257 UR - https://www.unboundmedicine.com/medline/citation/20629146/REM_sleep_behavior_disorder_is_not_linked_to_postural_instability_and_gait_dysfunction_in_Parkinson_ L2 - https://doi.org/10.1002/mds.23121 DB - PRIME DP - Unbound Medicine ER -