Tags

Type your tag names separated by a space and hit enter

Low-density lipoprotein receptor-related protein 5 polymorphisms are associated with bone mineral density in Greek postmenopausal women: an interaction with calcium intake.
J Am Diet Assoc. 2010 Jul; 110(7):1078-83.JA

Abstract

The low-density lipoprotein receptor-related protein 5 (LRP5) has been shown to play a significant role in bone biology. This study aimed to assess the association of four common polymorphisms of the LRP5 gene with bone mineral density (BMD) and possible genexcalcium intake interactions in Greek postmenopausal women. For this observational cross-sectional association study, healthy postmenopausal women (N=578) were recruited (between December 2006 and January 2008) and genotyped for four polymorphisms (rs1784235, rs491347, rs4988321, and rs4988330) in the LRP5 gene. Measurements of BMD were performed and detailed medical, dietary, and anthropometric data were recorded. Student t tests and multiple linear regression models were applied after controlling for potential covariates (ie, age, weight, height, and calcium intake). None of the polymorphisms was associated with the presence of osteoporosis, fractures, and hip BMD. All polymorphisms were associated with unadjusted spine BMD, with the exception of rs4988330. Only rs4988321 was associated with adjusted spine BMD, where the presence of the A allele was associated with significantly lower spine BMD compared with the GG genotype (P=0.002). An interaction of the rs4988321 polymorphism with calcium intake (P=0.016) was found. The carriers of the A allele demonstrated significantly lower spine BMD compared to GG homozygotes (P=0.001) only in the lowest calcium intake group (<680 mg/day), whereas in the highest calcium intake group no differences were found in BMD between genotypes. These findings demonstrate that both rs4988321 polymorphism and its interaction with calcium intake are associated with BMD, whereas higher calcium intake was shown to decrease the negative effect of this polymorphism on BMD.

Authors+Show Affiliations

Department of Dietetics and Nutrition, Harokopio University, 17671 Athens, Greece.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20630166

Citation

Stathopoulou, Maria G., et al. "Low-density Lipoprotein Receptor-related Protein 5 Polymorphisms Are Associated With Bone Mineral Density in Greek Postmenopausal Women: an Interaction With Calcium Intake." Journal of the American Dietetic Association, vol. 110, no. 7, 2010, pp. 1078-83.
Stathopoulou MG, Dedoussis GV, Trovas G, et al. Low-density lipoprotein receptor-related protein 5 polymorphisms are associated with bone mineral density in Greek postmenopausal women: an interaction with calcium intake. J Am Diet Assoc. 2010;110(7):1078-83.
Stathopoulou, M. G., Dedoussis, G. V., Trovas, G., Katsalira, A., Hammond, N., Deloukas, P., & Lyritis, G. P. (2010). Low-density lipoprotein receptor-related protein 5 polymorphisms are associated with bone mineral density in Greek postmenopausal women: an interaction with calcium intake. Journal of the American Dietetic Association, 110(7), 1078-83. https://doi.org/10.1016/j.jada.2010.04.007
Stathopoulou MG, et al. Low-density Lipoprotein Receptor-related Protein 5 Polymorphisms Are Associated With Bone Mineral Density in Greek Postmenopausal Women: an Interaction With Calcium Intake. J Am Diet Assoc. 2010;110(7):1078-83. PubMed PMID: 20630166.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Low-density lipoprotein receptor-related protein 5 polymorphisms are associated with bone mineral density in Greek postmenopausal women: an interaction with calcium intake. AU - Stathopoulou,Maria G, AU - Dedoussis,George V Z, AU - Trovas,George, AU - Katsalira,Aikaterini, AU - Hammond,Naomi, AU - Deloukas,Panos, AU - Lyritis,George P, PY - 2009/10/27/received PY - 2010/7/16/entrez PY - 2010/7/16/pubmed PY - 2010/7/28/medline SP - 1078 EP - 83 JF - Journal of the American Dietetic Association JO - J Am Diet Assoc VL - 110 IS - 7 N2 - The low-density lipoprotein receptor-related protein 5 (LRP5) has been shown to play a significant role in bone biology. This study aimed to assess the association of four common polymorphisms of the LRP5 gene with bone mineral density (BMD) and possible genexcalcium intake interactions in Greek postmenopausal women. For this observational cross-sectional association study, healthy postmenopausal women (N=578) were recruited (between December 2006 and January 2008) and genotyped for four polymorphisms (rs1784235, rs491347, rs4988321, and rs4988330) in the LRP5 gene. Measurements of BMD were performed and detailed medical, dietary, and anthropometric data were recorded. Student t tests and multiple linear regression models were applied after controlling for potential covariates (ie, age, weight, height, and calcium intake). None of the polymorphisms was associated with the presence of osteoporosis, fractures, and hip BMD. All polymorphisms were associated with unadjusted spine BMD, with the exception of rs4988330. Only rs4988321 was associated with adjusted spine BMD, where the presence of the A allele was associated with significantly lower spine BMD compared with the GG genotype (P=0.002). An interaction of the rs4988321 polymorphism with calcium intake (P=0.016) was found. The carriers of the A allele demonstrated significantly lower spine BMD compared to GG homozygotes (P=0.001) only in the lowest calcium intake group (<680 mg/day), whereas in the highest calcium intake group no differences were found in BMD between genotypes. These findings demonstrate that both rs4988321 polymorphism and its interaction with calcium intake are associated with BMD, whereas higher calcium intake was shown to decrease the negative effect of this polymorphism on BMD. SN - 1878-3570 UR - https://www.unboundmedicine.com/medline/citation/20630166/Low_density_lipoprotein_receptor_related_protein_5_polymorphisms_are_associated_with_bone_mineral_density_in_Greek_postmenopausal_women:_an_interaction_with_calcium_intake_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002-8223(10)00388-3 DB - PRIME DP - Unbound Medicine ER -