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Spatial analysis of air pollution and cancer incidence rates in Haifa Bay, Israel.
Sci Total Environ. 2010 Sep 15; 408(20):4429-39.ST

Abstract

The Israel National Cancer Registry reported in 2001 that cancer incidence rates in the Haifa area are roughly 20% above the national average. Since Haifa has been the major industrial center in Israel since 1930, concern has been raised that the elevated cancer rates may be associated with historically high air pollution levels. This work tests whether persistent spatial patterns of metrics of chronic exposure to air pollutants are associated with the observed patterns of cancer incidence rates. Risk metrics of chronic exposure to PM(10), emitted both by industry and traffic, and to SO(2), a marker of industrial emissions, was developed. Ward-based maps of standardized incidence rates of three prevalent cancers: Non-Hodgkin's lymphoma, lung cancer and bladder cancer were also produced. Global clustering tests were employed to filter out those cancers that show sufficiently random spatial distribution to have a nil probability of being related to the spatial non-random risk maps. A Bayesian method was employed to assess possible associations between the morbidity and risk patterns, accounting for the ward-based socioeconomic status ranking. Lung cancer in males and bladder cancer in both genders showed non-random spatial patterns. No significant associations between the SO(2)-based risk maps and any of the cancers were found. Lung cancer in males was found to be associated with PM(10), with the relative risk associated with an increase of 1 microg/m(3) of PM(10) being 12%. Special consideration of wards with expected rates <1 improved the results by decreasing the variance of the spatially correlated residual log-relative risk.

Authors+Show Affiliations

Faculty of Civil and Environmental Engineering, Technion, Israel Institute of Technology, Haifa 32000, Israel.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20630566

Citation

Eitan, Ori, et al. "Spatial Analysis of Air Pollution and Cancer Incidence Rates in Haifa Bay, Israel." The Science of the Total Environment, vol. 408, no. 20, 2010, pp. 4429-39.
Eitan O, Yuval , Barchana M, et al. Spatial analysis of air pollution and cancer incidence rates in Haifa Bay, Israel. Sci Total Environ. 2010;408(20):4429-39.
Eitan, O., Yuval, ., Barchana, M., Dubnov, J., Linn, S., Carmel, Y., & Broday, D. M. (2010). Spatial analysis of air pollution and cancer incidence rates in Haifa Bay, Israel. The Science of the Total Environment, 408(20), 4429-39. https://doi.org/10.1016/j.scitotenv.2010.06.031
Eitan O, et al. Spatial Analysis of Air Pollution and Cancer Incidence Rates in Haifa Bay, Israel. Sci Total Environ. 2010 Sep 15;408(20):4429-39. PubMed PMID: 20630566.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Spatial analysis of air pollution and cancer incidence rates in Haifa Bay, Israel. AU - Eitan,Ori, AU - Yuval,, AU - Barchana,Micha, AU - Dubnov,Jonathan, AU - Linn,Shai, AU - Carmel,Yohay, AU - Broday,David M, Y1 - 2010/07/13/ PY - 2009/10/13/received PY - 2010/05/14/revised PY - 2010/06/17/accepted PY - 2010/7/16/entrez PY - 2010/7/16/pubmed PY - 2010/9/25/medline SP - 4429 EP - 39 JF - The Science of the total environment JO - Sci Total Environ VL - 408 IS - 20 N2 - The Israel National Cancer Registry reported in 2001 that cancer incidence rates in the Haifa area are roughly 20% above the national average. Since Haifa has been the major industrial center in Israel since 1930, concern has been raised that the elevated cancer rates may be associated with historically high air pollution levels. This work tests whether persistent spatial patterns of metrics of chronic exposure to air pollutants are associated with the observed patterns of cancer incidence rates. Risk metrics of chronic exposure to PM(10), emitted both by industry and traffic, and to SO(2), a marker of industrial emissions, was developed. Ward-based maps of standardized incidence rates of three prevalent cancers: Non-Hodgkin's lymphoma, lung cancer and bladder cancer were also produced. Global clustering tests were employed to filter out those cancers that show sufficiently random spatial distribution to have a nil probability of being related to the spatial non-random risk maps. A Bayesian method was employed to assess possible associations between the morbidity and risk patterns, accounting for the ward-based socioeconomic status ranking. Lung cancer in males and bladder cancer in both genders showed non-random spatial patterns. No significant associations between the SO(2)-based risk maps and any of the cancers were found. Lung cancer in males was found to be associated with PM(10), with the relative risk associated with an increase of 1 microg/m(3) of PM(10) being 12%. Special consideration of wards with expected rates <1 improved the results by decreasing the variance of the spatially correlated residual log-relative risk. SN - 1879-1026 UR - https://www.unboundmedicine.com/medline/citation/20630566/Spatial_analysis_of_air_pollution_and_cancer_incidence_rates_in_Haifa_Bay_Israel_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0048-9697(10)00636-4 DB - PRIME DP - Unbound Medicine ER -