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Copper and ceruloplasmin abnormalities in Alzheimer's disease.

Abstract

The idea that copper may play a role in the pathogenesis of Alzheimer's disease is gaining momentum. Serum copper and ceruloplasmin were measured by both enzymatic (eCp) and immunologic (iCp) methods in 28 patients with Alzheimer's disease and 29 age-matched controls. ''Free copper'' was determined by subtracting copper accounted for in the eCp assay from total serum copper. Percentage free copper, that is the proportion of serum copper not bound to ceruloplasmin, was significantly elevated in patients with Alzheimer's compared to controls. There was significantly more ''defective'' ceruloplasmin, which is apoceruloplamin lacking its copper, in Alzheimer's disease than in normal controls. This abnormality may precede the clinical onset of the disease and help predict risk of disease onset. Increased exposure to environmental copper (eg, the spread of copper plumbing and the use of copper in supplements) and/or defective ceruloplasmin function may play a role in the current epidemic of Alzheimer's disease.

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  • Authors+Show Affiliations

    ,

    Department of Human Genetics, University of Michigan, Ann Arbor, 48103, USA. brewergj@umich.edu

    , , , ,

    Source

    MeSH

    Aged
    Aged, 80 and over
    Alzheimer Disease
    Apoproteins
    Biomarkers
    Ceruloplasmin
    Copper
    Enzyme Activation
    Female
    Humans
    Male
    Middle Aged
    Predictive Value of Tests
    Risk Factors

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    20631161

    Citation

    Brewer, George J., et al. "Copper and Ceruloplasmin Abnormalities in Alzheimer's Disease." American Journal of Alzheimer's Disease and Other Dementias, vol. 25, no. 6, 2010, pp. 490-7.
    Brewer GJ, Kanzer SH, Zimmerman EA, et al. Copper and ceruloplasmin abnormalities in Alzheimer's disease. Am J Alzheimers Dis Other Demen. 2010;25(6):490-7.
    Brewer, G. J., Kanzer, S. H., Zimmerman, E. A., Celmins, D. F., Heckman, S. M., & Dick, R. (2010). Copper and ceruloplasmin abnormalities in Alzheimer's disease. American Journal of Alzheimer's Disease and Other Dementias, 25(6), pp. 490-7. doi:10.1177/1533317510375083.
    Brewer GJ, et al. Copper and Ceruloplasmin Abnormalities in Alzheimer's Disease. Am J Alzheimers Dis Other Demen. 2010;25(6):490-7. PubMed PMID: 20631161.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Copper and ceruloplasmin abnormalities in Alzheimer's disease. AU - Brewer,George J, AU - Kanzer,Steve H, AU - Zimmerman,Earl A, AU - Celmins,Dzintra F, AU - Heckman,Susan M, AU - Dick,Robert, Y1 - 2010/07/14/ PY - 2010/7/16/entrez PY - 2010/7/16/pubmed PY - 2010/12/29/medline SP - 490 EP - 7 JF - American journal of Alzheimer's disease and other dementias JO - Am J Alzheimers Dis Other Demen VL - 25 IS - 6 N2 - The idea that copper may play a role in the pathogenesis of Alzheimer's disease is gaining momentum. Serum copper and ceruloplasmin were measured by both enzymatic (eCp) and immunologic (iCp) methods in 28 patients with Alzheimer's disease and 29 age-matched controls. ''Free copper'' was determined by subtracting copper accounted for in the eCp assay from total serum copper. Percentage free copper, that is the proportion of serum copper not bound to ceruloplasmin, was significantly elevated in patients with Alzheimer's compared to controls. There was significantly more ''defective'' ceruloplasmin, which is apoceruloplamin lacking its copper, in Alzheimer's disease than in normal controls. This abnormality may precede the clinical onset of the disease and help predict risk of disease onset. Increased exposure to environmental copper (eg, the spread of copper plumbing and the use of copper in supplements) and/or defective ceruloplasmin function may play a role in the current epidemic of Alzheimer's disease. SN - 1938-2731 UR - https://www.unboundmedicine.com/medline/citation/20631161/Copper_and_ceruloplasmin_abnormalities_in_Alzheimer's_disease_ L2 - http://journals.sagepub.com/doi/full/10.1177/1533317510375083?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -