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Update on methodologies available for ciguatoxin determination: perspectives to confront the onset of ciguatera fish poisoning in Europe.
Mar Drugs. 2010 Jun 14; 8(6):1838-907.MD

Abstract

Ciguatera fish poisoning (CFP) occurs mainly when humans ingest finfish contaminated with ciguatoxins (CTXs). The complexity and variability of such toxins have made it difficult to develop reliable methods to routinely monitor CFP with specificity and sensitivity. This review aims to describe the methodologies available for CTX detection, including those based on the toxicological, biochemical, chemical, and pharmaceutical properties of CTXs. Selecting any of these methodological approaches for routine monitoring of ciguatera may be dependent upon the applicability of the method. However, identifying a reference validation method for CTXs is a critical and urgent issue, and is dependent upon the availability of certified CTX standards and the coordinated action of laboratories. Reports of CFP cases in European hospitals have been described in several countries, and are mostly due to travel to CFP endemic areas. Additionally, the recent detection of the CTX-producing tropical genus Gambierdiscus in the eastern Atlantic Ocean of the northern hemisphere and in the Mediterranean Sea, as well as the confirmation of CFP in the Canary Islands and possibly in Madeira, constitute other reasons to study the onset of CFP in Europe [1]. The question of the possible contribution of climate change to the distribution of toxin-producing microalgae and ciguateric fish is raised. The impact of ciguatera onset on European Union (EU) policies will be discussed with respect to EU regulations on marine toxins in seafood. Critical analysis and availability of methodologies for CTX determination is required for a rapid response to suspected CFP cases and to conduct sound CFP risk analysis.

Authors+Show Affiliations

IRTA, Ctra. Poble Nou, Sant Carles de la Ràpita, Spain. amandine.caillaud@irta.esNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

20631873

Citation

Caillaud, Amandine, et al. "Update On Methodologies Available for Ciguatoxin Determination: Perspectives to Confront the Onset of Ciguatera Fish Poisoning in Europe." Marine Drugs, vol. 8, no. 6, 2010, pp. 1838-907.
Caillaud A, de la Iglesia P, Darius HT, et al. Update on methodologies available for ciguatoxin determination: perspectives to confront the onset of ciguatera fish poisoning in Europe. Mar Drugs. 2010;8(6):1838-907.
Caillaud, A., de la Iglesia, P., Darius, H. T., Pauillac, S., Aligizaki, K., Fraga, S., Chinain, M., & Diogène, J. (2010). Update on methodologies available for ciguatoxin determination: perspectives to confront the onset of ciguatera fish poisoning in Europe. Marine Drugs, 8(6), 1838-907. https://doi.org/10.3390/md8061838
Caillaud A, et al. Update On Methodologies Available for Ciguatoxin Determination: Perspectives to Confront the Onset of Ciguatera Fish Poisoning in Europe. Mar Drugs. 2010 Jun 14;8(6):1838-907. PubMed PMID: 20631873.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Update on methodologies available for ciguatoxin determination: perspectives to confront the onset of ciguatera fish poisoning in Europe. AU - Caillaud,Amandine, AU - de la Iglesia,Pablo, AU - Darius,H Taiana, AU - Pauillac,Serge, AU - Aligizaki,Katerina, AU - Fraga,Santiago, AU - Chinain,Mireille, AU - Diogène,Jorge, Y1 - 2010/06/14/ PY - 2010/04/06/received PY - 2010/05/18/revised PY - 2010/06/10/accepted PY - 2010/7/16/entrez PY - 2010/7/16/pubmed PY - 2011/2/18/medline KW - CFP KW - Europe KW - Gambierdiscus KW - ciguatera KW - ciguatoxin KW - detection methods KW - methods SP - 1838 EP - 907 JF - Marine drugs JO - Mar Drugs VL - 8 IS - 6 N2 - Ciguatera fish poisoning (CFP) occurs mainly when humans ingest finfish contaminated with ciguatoxins (CTXs). The complexity and variability of such toxins have made it difficult to develop reliable methods to routinely monitor CFP with specificity and sensitivity. This review aims to describe the methodologies available for CTX detection, including those based on the toxicological, biochemical, chemical, and pharmaceutical properties of CTXs. Selecting any of these methodological approaches for routine monitoring of ciguatera may be dependent upon the applicability of the method. However, identifying a reference validation method for CTXs is a critical and urgent issue, and is dependent upon the availability of certified CTX standards and the coordinated action of laboratories. Reports of CFP cases in European hospitals have been described in several countries, and are mostly due to travel to CFP endemic areas. Additionally, the recent detection of the CTX-producing tropical genus Gambierdiscus in the eastern Atlantic Ocean of the northern hemisphere and in the Mediterranean Sea, as well as the confirmation of CFP in the Canary Islands and possibly in Madeira, constitute other reasons to study the onset of CFP in Europe [1]. The question of the possible contribution of climate change to the distribution of toxin-producing microalgae and ciguateric fish is raised. The impact of ciguatera onset on European Union (EU) policies will be discussed with respect to EU regulations on marine toxins in seafood. Critical analysis and availability of methodologies for CTX determination is required for a rapid response to suspected CFP cases and to conduct sound CFP risk analysis. SN - 1660-3397 UR - https://www.unboundmedicine.com/medline/citation/20631873/Update_on_methodologies_available_for_ciguatoxin_determination:_perspectives_to_confront_the_onset_of_ciguatera_fish_poisoning_in_Europe_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20631873/ DB - PRIME DP - Unbound Medicine ER -