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Tissue-specific splicing in vivo of the beta-tropomyosin gene: dependence on an RNA secondary structure.
Science. 1991 Jun 28; 252(5014):1842-5.Sci

Abstract

The beta-tropomyosin gene in chicken contains two mutually exclusive exons (exons 6A and 6B) which are used by the splicing apparatus in myogenic cells, respectively, before (myoblast stage) and after (myotube stage) differentiation. The myoblast splicing pattern is shown to depend on multiple sequence elements that are located in the upstream intron and in the exon 6B and that exert a negative control over exon 6B splicing. This regulation of splicing is due, at least in part, to a secondary structure of the primary transcript, which limits in vivo the accessibility of exon 6B in myoblasts.

Authors+Show Affiliations

Institut Pasteur, Paris, France.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

2063196

Citation

Libri, D, et al. "Tissue-specific Splicing in Vivo of the Beta-tropomyosin Gene: Dependence On an RNA Secondary Structure." Science (New York, N.Y.), vol. 252, no. 5014, 1991, pp. 1842-5.
Libri D, Piseri A, Fiszman MY. Tissue-specific splicing in vivo of the beta-tropomyosin gene: dependence on an RNA secondary structure. Science. 1991;252(5014):1842-5.
Libri, D., Piseri, A., & Fiszman, M. Y. (1991). Tissue-specific splicing in vivo of the beta-tropomyosin gene: dependence on an RNA secondary structure. Science (New York, N.Y.), 252(5014), 1842-5.
Libri D, Piseri A, Fiszman MY. Tissue-specific Splicing in Vivo of the Beta-tropomyosin Gene: Dependence On an RNA Secondary Structure. Science. 1991 Jun 28;252(5014):1842-5. PubMed PMID: 2063196.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Tissue-specific splicing in vivo of the beta-tropomyosin gene: dependence on an RNA secondary structure. AU - Libri,D, AU - Piseri,A, AU - Fiszman,M Y, PY - 1991/6/28/pubmed PY - 1991/6/28/medline PY - 1991/6/28/entrez SP - 1842 EP - 5 JF - Science (New York, N.Y.) JO - Science VL - 252 IS - 5014 N2 - The beta-tropomyosin gene in chicken contains two mutually exclusive exons (exons 6A and 6B) which are used by the splicing apparatus in myogenic cells, respectively, before (myoblast stage) and after (myotube stage) differentiation. The myoblast splicing pattern is shown to depend on multiple sequence elements that are located in the upstream intron and in the exon 6B and that exert a negative control over exon 6B splicing. This regulation of splicing is due, at least in part, to a secondary structure of the primary transcript, which limits in vivo the accessibility of exon 6B in myoblasts. SN - 0036-8075 UR - https://www.unboundmedicine.com/medline/citation/2063196/Tissue_specific_splicing_in_vivo_of_the_beta_tropomyosin_gene:_dependence_on_an_RNA_secondary_structure_ L2 - https://www.sciencemag.org/cgi/pmidlookup?view=long&pmid=2063196 DB - PRIME DP - Unbound Medicine ER -