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Regulatory protein Yap1 is involved in response of yeast Saccharomyces cerevisiae to nitrosative stress.
Biochemistry (Mosc). 2010 May; 75(5):629-64.B

Abstract

The goal of this work was to investigate the possible involvement of protein transcription factor Yap1 in regulation of activity of antioxidant enzymes superoxide dismutase and catalase during yeast response to nitrosative stress. It was found that the inactivation of the YAP1 gene, encoding Yap1p, cancelled the activation of superoxide dismutase and catalase by NO-donors. Then, using chimeric protein Yap1-GFP, we found the accumulation of Yap1p in the nucleus in response to nitrosative stress. Therefore, we conclude that these results in combination with previous data clearly demonstrate the involvement of Yap1p in upregulation of superoxide dismutase and catalase in yeast cells in response to nitrosative stress.

Authors+Show Affiliations

Department of Biochemistry, Vassyl Stefanyk Precarpathian National University, Ivano-Frankivsk, 76025, Ukraine. lushchak@pu.if.uaNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

20632943

Citation

Lushchak, O V., et al. "Regulatory Protein Yap1 Is Involved in Response of Yeast Saccharomyces Cerevisiae to Nitrosative Stress." Biochemistry. Biokhimiia, vol. 75, no. 5, 2010, pp. 629-64.
Lushchak OV, Inoue Y, Lushchak VI. Regulatory protein Yap1 is involved in response of yeast Saccharomyces cerevisiae to nitrosative stress. Biochemistry (Mosc). 2010;75(5):629-64.
Lushchak, O. V., Inoue, Y., & Lushchak, V. I. (2010). Regulatory protein Yap1 is involved in response of yeast Saccharomyces cerevisiae to nitrosative stress. Biochemistry. Biokhimiia, 75(5), 629-64.
Lushchak OV, Inoue Y, Lushchak VI. Regulatory Protein Yap1 Is Involved in Response of Yeast Saccharomyces Cerevisiae to Nitrosative Stress. Biochemistry (Mosc). 2010;75(5):629-64. PubMed PMID: 20632943.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Regulatory protein Yap1 is involved in response of yeast Saccharomyces cerevisiae to nitrosative stress. AU - Lushchak,O V, AU - Inoue,Y, AU - Lushchak,V I, PY - 2010/7/17/entrez PY - 2010/7/17/pubmed PY - 2010/11/11/medline SP - 629 EP - 64 JF - Biochemistry. Biokhimiia JO - Biochemistry (Mosc) VL - 75 IS - 5 N2 - The goal of this work was to investigate the possible involvement of protein transcription factor Yap1 in regulation of activity of antioxidant enzymes superoxide dismutase and catalase during yeast response to nitrosative stress. It was found that the inactivation of the YAP1 gene, encoding Yap1p, cancelled the activation of superoxide dismutase and catalase by NO-donors. Then, using chimeric protein Yap1-GFP, we found the accumulation of Yap1p in the nucleus in response to nitrosative stress. Therefore, we conclude that these results in combination with previous data clearly demonstrate the involvement of Yap1p in upregulation of superoxide dismutase and catalase in yeast cells in response to nitrosative stress. SN - 1608-3040 UR - https://www.unboundmedicine.com/medline/citation/20632943/Regulatory_protein_Yap1_is_involved_in_response_of_yeast_Saccharomyces_cerevisiae_to_nitrosative_stress_ L2 - https://doi.org/10.1134/s0006297910050135 DB - PRIME DP - Unbound Medicine ER -