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Serial coronary CT angiography-verified changes in plaque characteristics as an end point: evaluation of effect of statin intervention.
JACC Cardiovasc Imaging. 2010 Jul; 3(7):691-8.JC

Abstract

OBJECTIVES

This study sought to assess, by serial computed tomography angiography (CTA), the effect of statin treatment on coronary plaque morphology.

BACKGROUND

In addition to the assessment of luminal stenosis, CTA also allows characterization of plaque morphology. Large, positively remodeled plaques with large necrotic cores have been reported as indicators of plaque instability.

METHODS

CTA was performed in 32 patients (26 men, ages 64.3 +/- 8.5 years). Of these, 24 received fluvastatin after the baseline study; 8 subjects who refused statin treatment were followed as the control subjects. Serial imaging was performed after a median interval of 12 months. All vessels were examined in every subject, and a 10-mm-long segment was identified for comparison before and after intervention. Total plaque volume, low attenuation plaque (LAP) volume, lumen volume, and remodeling index were calculated.

RESULTS

In the statin-treated patients, the total plaque volume (92.3 +/- 37.7 vs. 76.4 +/- 26.5 mm(3), p < 0.01) and LAP volume (4.9 +/- 7.8 vs. 1.3 +/- 2.3 mm(3), p = 0.01) were significantly reduced over time; however, there was no change in the lumen volume (63.9 +/- 25.3 vs. 65.2 +/- 26.2 mm(3), p = 0.59). On the other hand, no change was observed in the CTA characteristics in the control subjects, including total plaque volume (94.4 +/- 21.2 vs. 98.4 +/- 28.6 mm(3), p = 0.48), LAP volume (2.1 +/- 3.0 vs. 2.3 +/- 3.6 mm(3), p = 0.91), and lumen volume (80.5 +/- 20.7 vs. 75.0 +/- 16.3 mm(3), p = 0.26). The plaque volume change (-15.9 +/- 22.2 vs. 4.0 +/- 14.0 mm(3), p = 0.01) and LAP volume change (-3.7 +/- 7.0 vs. 0.2 +/- 1.5 mm(3), p < 0.01) were significantly greater in the statin than the control group. The lumen volume (1.3 +/- 15.6 vs. -5.5 +/- 13.1 mm(3), p = 0.24) and remodeling index (-2.4 +/- 6.8% vs. -0.3 +/- 6.5%, p = 0.53) did not show the significant differences between the 2 groups. The decrease in the plaque volume was due to reduction in the LAP volume (R = 0.83, p < 0.01), and was not related to any changes in the lumen volume (R = 0.21, p = 0.24).

CONCLUSIONS

This preliminary study suggests that serial CTA evaluation of coronary plaques allows for the assessment of interval change in the plaque morphology. Statin treatment results in decreases in the plaque and necrotic core volume. The features known to be associated with plaque instability.

Authors+Show Affiliations

Department of Cardiology, Fujita Health University, Toyoake, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

20633846

Citation

Inoue, Kaori, et al. "Serial Coronary CT Angiography-verified Changes in Plaque Characteristics as an End Point: Evaluation of Effect of Statin Intervention." JACC. Cardiovascular Imaging, vol. 3, no. 7, 2010, pp. 691-8.
Inoue K, Motoyama S, Sarai M, et al. Serial coronary CT angiography-verified changes in plaque characteristics as an end point: evaluation of effect of statin intervention. JACC Cardiovasc Imaging. 2010;3(7):691-8.
Inoue, K., Motoyama, S., Sarai, M., Sato, T., Harigaya, H., Hara, T., Sanda, Y., Anno, H., Kondo, T., Wong, N. D., Narula, J., & Ozaki, Y. (2010). Serial coronary CT angiography-verified changes in plaque characteristics as an end point: evaluation of effect of statin intervention. JACC. Cardiovascular Imaging, 3(7), 691-8. https://doi.org/10.1016/j.jcmg.2010.04.011
Inoue K, et al. Serial Coronary CT Angiography-verified Changes in Plaque Characteristics as an End Point: Evaluation of Effect of Statin Intervention. JACC Cardiovasc Imaging. 2010;3(7):691-8. PubMed PMID: 20633846.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serial coronary CT angiography-verified changes in plaque characteristics as an end point: evaluation of effect of statin intervention. AU - Inoue,Kaori, AU - Motoyama,Sadako, AU - Sarai,Masayoshi, AU - Sato,Takahisa, AU - Harigaya,Hiroto, AU - Hara,Tomonori, AU - Sanda,Yoshihiro, AU - Anno,Hirofumi, AU - Kondo,Takeshi, AU - Wong,Nathan D, AU - Narula,Jagat, AU - Ozaki,Yukio, PY - 2010/02/25/received PY - 2010/04/21/revised PY - 2010/04/26/accepted PY - 2010/7/17/entrez PY - 2010/7/17/pubmed PY - 2010/11/3/medline SP - 691 EP - 8 JF - JACC. Cardiovascular imaging JO - JACC Cardiovasc Imaging VL - 3 IS - 7 N2 - OBJECTIVES: This study sought to assess, by serial computed tomography angiography (CTA), the effect of statin treatment on coronary plaque morphology. BACKGROUND: In addition to the assessment of luminal stenosis, CTA also allows characterization of plaque morphology. Large, positively remodeled plaques with large necrotic cores have been reported as indicators of plaque instability. METHODS: CTA was performed in 32 patients (26 men, ages 64.3 +/- 8.5 years). Of these, 24 received fluvastatin after the baseline study; 8 subjects who refused statin treatment were followed as the control subjects. Serial imaging was performed after a median interval of 12 months. All vessels were examined in every subject, and a 10-mm-long segment was identified for comparison before and after intervention. Total plaque volume, low attenuation plaque (LAP) volume, lumen volume, and remodeling index were calculated. RESULTS: In the statin-treated patients, the total plaque volume (92.3 +/- 37.7 vs. 76.4 +/- 26.5 mm(3), p < 0.01) and LAP volume (4.9 +/- 7.8 vs. 1.3 +/- 2.3 mm(3), p = 0.01) were significantly reduced over time; however, there was no change in the lumen volume (63.9 +/- 25.3 vs. 65.2 +/- 26.2 mm(3), p = 0.59). On the other hand, no change was observed in the CTA characteristics in the control subjects, including total plaque volume (94.4 +/- 21.2 vs. 98.4 +/- 28.6 mm(3), p = 0.48), LAP volume (2.1 +/- 3.0 vs. 2.3 +/- 3.6 mm(3), p = 0.91), and lumen volume (80.5 +/- 20.7 vs. 75.0 +/- 16.3 mm(3), p = 0.26). The plaque volume change (-15.9 +/- 22.2 vs. 4.0 +/- 14.0 mm(3), p = 0.01) and LAP volume change (-3.7 +/- 7.0 vs. 0.2 +/- 1.5 mm(3), p < 0.01) were significantly greater in the statin than the control group. The lumen volume (1.3 +/- 15.6 vs. -5.5 +/- 13.1 mm(3), p = 0.24) and remodeling index (-2.4 +/- 6.8% vs. -0.3 +/- 6.5%, p = 0.53) did not show the significant differences between the 2 groups. The decrease in the plaque volume was due to reduction in the LAP volume (R = 0.83, p < 0.01), and was not related to any changes in the lumen volume (R = 0.21, p = 0.24). CONCLUSIONS: This preliminary study suggests that serial CTA evaluation of coronary plaques allows for the assessment of interval change in the plaque morphology. Statin treatment results in decreases in the plaque and necrotic core volume. The features known to be associated with plaque instability. SN - 1876-7591 UR - https://www.unboundmedicine.com/medline/citation/20633846/Serial_coronary_CT_angiography_verified_changes_in_plaque_characteristics_as_an_end_point:_evaluation_of_effect_of_statin_intervention_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1936-878X(10)00282-2 DB - PRIME DP - Unbound Medicine ER -