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Use of fertility drugs and risk of endometrial cancer in an Italian case-control study.
Eur J Cancer Prev 2010; 19(6):428-30EJ

Abstract

The objective of this study was to analyse time-related aspects of the use of fertility drugs related to the risk of endometrial cancer using data from a case-control study conducted between 1992 and 2006 in Italy. The study included 454 cases (median age, 60 years; range, 18-79) with incident, histologically confirmed endometrial cancer and 908 female controls (median age, 61 years; range 19-79) admitted to the same network of hospitals as cases for a wide spectrum of acute, non-neoplastic conditions. Controls were frequency matched to cases with a 2:1 ratio for age and study centre. Information was collected by trained interviewers using a structured questionnaire. We calculated odds ratios (ORs) and the corresponding 95% confidence intervals (CI) using conditional logistic regression models adjusted for major relevant covariates. The OR of endometrial cancer for ever use of fertility drugs was 3.26 (95% CI, 1.07-9.95). The risk was higher for duration of use 12 months or more (OR=6.10; 95% CI, 0.96-38.6), time since last use 25 years or less before the interview (OR=5.30; 95% CI, 1.12-25.1), and for age at first use less than 30 years (OR=5.14; 95% CI, 1.13-23.4). The association was apparently stronger in ever-gravid (OR=6.50; 95% CI, 1.10-38.3) than in nulligravid (OR=2.83; 95% CI, 0.32-25.0) women. Our data support earlier findings of an increase in risk of endometrial cancer with duration of use of fertility drugs.

Authors+Show Affiliations

II Clinica Ostetrica Ginecologica, Università di Milano, Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli, Regina Elena, Milan, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20634699

Citation

Parazzini, Fabio, et al. "Use of Fertility Drugs and Risk of Endometrial Cancer in an Italian Case-control Study." European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP), vol. 19, no. 6, 2010, pp. 428-30.
Parazzini F, Pelucchi C, Talamini R, et al. Use of fertility drugs and risk of endometrial cancer in an Italian case-control study. Eur J Cancer Prev. 2010;19(6):428-30.
Parazzini, F., Pelucchi, C., Talamini, R., Montella, M., & La Vecchia, C. (2010). Use of fertility drugs and risk of endometrial cancer in an Italian case-control study. European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP), 19(6), pp. 428-30. doi:10.1097/CEJ.0b013e32833d9388.
Parazzini F, et al. Use of Fertility Drugs and Risk of Endometrial Cancer in an Italian Case-control Study. Eur J Cancer Prev. 2010;19(6):428-30. PubMed PMID: 20634699.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Use of fertility drugs and risk of endometrial cancer in an Italian case-control study. AU - Parazzini,Fabio, AU - Pelucchi,Claudio, AU - Talamini,Renato, AU - Montella,Maurizio, AU - La Vecchia,Carlo, PY - 2010/7/17/entrez PY - 2010/7/17/pubmed PY - 2011/1/7/medline SP - 428 EP - 30 JF - European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) JO - Eur. J. Cancer Prev. VL - 19 IS - 6 N2 - The objective of this study was to analyse time-related aspects of the use of fertility drugs related to the risk of endometrial cancer using data from a case-control study conducted between 1992 and 2006 in Italy. The study included 454 cases (median age, 60 years; range, 18-79) with incident, histologically confirmed endometrial cancer and 908 female controls (median age, 61 years; range 19-79) admitted to the same network of hospitals as cases for a wide spectrum of acute, non-neoplastic conditions. Controls were frequency matched to cases with a 2:1 ratio for age and study centre. Information was collected by trained interviewers using a structured questionnaire. We calculated odds ratios (ORs) and the corresponding 95% confidence intervals (CI) using conditional logistic regression models adjusted for major relevant covariates. The OR of endometrial cancer for ever use of fertility drugs was 3.26 (95% CI, 1.07-9.95). The risk was higher for duration of use 12 months or more (OR=6.10; 95% CI, 0.96-38.6), time since last use 25 years or less before the interview (OR=5.30; 95% CI, 1.12-25.1), and for age at first use less than 30 years (OR=5.14; 95% CI, 1.13-23.4). The association was apparently stronger in ever-gravid (OR=6.50; 95% CI, 1.10-38.3) than in nulligravid (OR=2.83; 95% CI, 0.32-25.0) women. Our data support earlier findings of an increase in risk of endometrial cancer with duration of use of fertility drugs. SN - 1473-5709 UR - https://www.unboundmedicine.com/medline/citation/20634699/Use_of_fertility_drugs_and_risk_of_endometrial_cancer_in_an_Italian_case_control_study_ L2 - http://Insights.ovid.com/pubmed?pmid=20634699 DB - PRIME DP - Unbound Medicine ER -