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Determination of four thiophenethylamine designer drugs (2C-T-4, 2C-T-8, 2C-T-13, 2C-T-17) in human urine by capillary electrophoresis/mass spectrometry.
Rapid Commun Mass Spectrom. 2010 Aug 30; 24(16):2357-62.RC

Abstract

An analytical procedure for the simultaneous determination in human urine of four thiophenethylamine designer drugs (2C-T series) is reported. The quantitative analysis was performed by capillary electrophoresis with mass spectrometric detection (CE/MS), using 2,5-dimethoxy-4-methylthiophenethylamine-D(4) (2C-T-D(4)) as internal standard. In order to minimize interferences with matrix components and to preconcentrate target analytes, solid-phase extraction (SPE) was introduced in the method as a clean-up step. The method was validated according to international guidelines. The data for accuracy and precision were within required limits. Calibration curves were generated over the range from 10 to 500 ng mL(-1) and correlation coefficients always exceeded 0.997. The method was demonstrated to be specific, sensitive, and reliable for the analysis of these derivatives in urine samples.

Authors+Show Affiliations

Dipartimento Farmaco Chimico Tossicologico, Università di Sassari, 07100 Sassari, Italy. marvi@uniss.itNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Evaluation Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20635321

Citation

Nieddu, Maria, et al. "Determination of Four Thiophenethylamine Designer Drugs (2C-T-4, 2C-T-8, 2C-T-13, 2C-T-17) in Human Urine By Capillary Electrophoresis/mass Spectrometry." Rapid Communications in Mass Spectrometry : RCM, vol. 24, no. 16, 2010, pp. 2357-62.
Nieddu M, Boatto G, Pirisi MA, et al. Determination of four thiophenethylamine designer drugs (2C-T-4, 2C-T-8, 2C-T-13, 2C-T-17) in human urine by capillary electrophoresis/mass spectrometry. Rapid Commun Mass Spectrom. 2010;24(16):2357-62.
Nieddu, M., Boatto, G., Pirisi, M. A., & Dessì, G. (2010). Determination of four thiophenethylamine designer drugs (2C-T-4, 2C-T-8, 2C-T-13, 2C-T-17) in human urine by capillary electrophoresis/mass spectrometry. Rapid Communications in Mass Spectrometry : RCM, 24(16), 2357-62. https://doi.org/10.1002/rcm.4656
Nieddu M, et al. Determination of Four Thiophenethylamine Designer Drugs (2C-T-4, 2C-T-8, 2C-T-13, 2C-T-17) in Human Urine By Capillary Electrophoresis/mass Spectrometry. Rapid Commun Mass Spectrom. 2010 Aug 30;24(16):2357-62. PubMed PMID: 20635321.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Determination of four thiophenethylamine designer drugs (2C-T-4, 2C-T-8, 2C-T-13, 2C-T-17) in human urine by capillary electrophoresis/mass spectrometry. AU - Nieddu,Maria, AU - Boatto,Gianpiero, AU - Pirisi,Maria Antonietta, AU - Dessì,Giuseppina, PY - 2010/7/17/entrez PY - 2010/7/17/pubmed PY - 2010/11/5/medline SP - 2357 EP - 62 JF - Rapid communications in mass spectrometry : RCM JO - Rapid Commun Mass Spectrom VL - 24 IS - 16 N2 - An analytical procedure for the simultaneous determination in human urine of four thiophenethylamine designer drugs (2C-T series) is reported. The quantitative analysis was performed by capillary electrophoresis with mass spectrometric detection (CE/MS), using 2,5-dimethoxy-4-methylthiophenethylamine-D(4) (2C-T-D(4)) as internal standard. In order to minimize interferences with matrix components and to preconcentrate target analytes, solid-phase extraction (SPE) was introduced in the method as a clean-up step. The method was validated according to international guidelines. The data for accuracy and precision were within required limits. Calibration curves were generated over the range from 10 to 500 ng mL(-1) and correlation coefficients always exceeded 0.997. The method was demonstrated to be specific, sensitive, and reliable for the analysis of these derivatives in urine samples. SN - 1097-0231 UR - https://www.unboundmedicine.com/medline/citation/20635321/Determination_of_four_thiophenethylamine_designer_drugs__2C_T_4_2C_T_8_2C_T_13_2C_T_17__in_human_urine_by_capillary_electrophoresis/mass_spectrometry_ L2 - https://doi.org/10.1002/rcm.4656 DB - PRIME DP - Unbound Medicine ER -