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Impact of metabolic syndrome and its individual components on the presence and severity of angiographic coronary artery disease.
Yonsei Med J. 2010 Sep; 51(5):676-82.YM

Abstract

PURPOSE

Metabolic syndrome (MS) has been reported as a potential risk factor of coronary artery disease (CAD). The aims of this study were to assess whether there was a relationship between MS score and CAD angiographic severity, and to assess the predictive value of individual components of MS for CAD.

MATERIALS AND METHODS

We retrospectively enrolled 632 patients who underwent coronary angiography for suspected CAD (394 men, 61.0 +/- 10.6 years of age). MS was defined by the National Cholesterol Education Program criteria with the waist criterion modified into a body mass index (BMI) of more than 25 kg/m(2). The MS score defined as the number of MS components. CAD was defined as > 50% luminal diameter stenosis of at least one major epicardial coronary artery. CAD angiographic severity was evaluated with a Gensini scoring system.

RESULTS

Of the patients, 497 (78.6%) had CAD and 283 (44.8%) were diagnosed with MS. The MS score was significantly related to the Gensini score. High fasting blood glucose (FBG) was the only predictive factor for CAD. A cluster including high FBG, high blood pressure (BP), and low high-density lipoprotein cholesterol (HDL-C) showed the highest CAD risk.

CONCLUSION

The MS score correlates with the angiographic severity of CAD. The predictive ability of MS for CAD was carried almost completely by high FBG, and individual traits with high BP and low HDLC may act synergistically as risk factors for CAD.

Authors+Show Affiliations

Cardiology Division, Department of Internal Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20635441

Citation

Kim, Jong-Youn, et al. "Impact of Metabolic Syndrome and Its Individual Components On the Presence and Severity of Angiographic Coronary Artery Disease." Yonsei Medical Journal, vol. 51, no. 5, 2010, pp. 676-82.
Kim JY, Mun HS, Lee BK, et al. Impact of metabolic syndrome and its individual components on the presence and severity of angiographic coronary artery disease. Yonsei Med J. 2010;51(5):676-82.
Kim, J. Y., Mun, H. S., Lee, B. K., Yoon, S. B., Choi, E. Y., Min, P. K., Yoon, Y. W., Hong, B. K., Rim, S. J., & Kwon, H. M. (2010). Impact of metabolic syndrome and its individual components on the presence and severity of angiographic coronary artery disease. Yonsei Medical Journal, 51(5), 676-82. https://doi.org/10.3349/ymj.2010.51.5.676
Kim JY, et al. Impact of Metabolic Syndrome and Its Individual Components On the Presence and Severity of Angiographic Coronary Artery Disease. Yonsei Med J. 2010;51(5):676-82. PubMed PMID: 20635441.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Impact of metabolic syndrome and its individual components on the presence and severity of angiographic coronary artery disease. AU - Kim,Jong-Youn, AU - Mun,Hee-Sun, AU - Lee,Byoung Kwon, AU - Yoon,Seong Bo, AU - Choi,Eui-Young, AU - Min,Pil-Ki, AU - Yoon,Young-Won, AU - Hong,Bum-Kee, AU - Rim,Se-Joong, AU - Kwon,Hyuck Moon, PY - 2010/7/17/entrez PY - 2010/7/17/pubmed PY - 2010/11/3/medline SP - 676 EP - 82 JF - Yonsei medical journal JO - Yonsei Med J VL - 51 IS - 5 N2 - PURPOSE: Metabolic syndrome (MS) has been reported as a potential risk factor of coronary artery disease (CAD). The aims of this study were to assess whether there was a relationship between MS score and CAD angiographic severity, and to assess the predictive value of individual components of MS for CAD. MATERIALS AND METHODS: We retrospectively enrolled 632 patients who underwent coronary angiography for suspected CAD (394 men, 61.0 +/- 10.6 years of age). MS was defined by the National Cholesterol Education Program criteria with the waist criterion modified into a body mass index (BMI) of more than 25 kg/m(2). The MS score defined as the number of MS components. CAD was defined as > 50% luminal diameter stenosis of at least one major epicardial coronary artery. CAD angiographic severity was evaluated with a Gensini scoring system. RESULTS: Of the patients, 497 (78.6%) had CAD and 283 (44.8%) were diagnosed with MS. The MS score was significantly related to the Gensini score. High fasting blood glucose (FBG) was the only predictive factor for CAD. A cluster including high FBG, high blood pressure (BP), and low high-density lipoprotein cholesterol (HDL-C) showed the highest CAD risk. CONCLUSION: The MS score correlates with the angiographic severity of CAD. The predictive ability of MS for CAD was carried almost completely by high FBG, and individual traits with high BP and low HDLC may act synergistically as risk factors for CAD. SN - 1976-2437 UR - https://www.unboundmedicine.com/medline/citation/20635441/Impact_of_metabolic_syndrome_and_its_individual_components_on_the_presence_and_severity_of_angiographic_coronary_artery_disease_ L2 - https://www.eymj.org/DOIx.php?id=10.3349/ymj.2010.51.5.676 DB - PRIME DP - Unbound Medicine ER -