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No effect of group-based aerobic interval training on N-terminal pro- B-type natriuretic peptide levels in patients with chronic heart failure.
Scand Cardiovasc J. 2010 Aug; 44(4):223-9.SC

Abstract

OBJECTIVES

Exercise training might improve cardiac function as well as functional capacity in patients with chronic heart failure (CHF). N-terminal pro-B-type natriuretic peptide (NT pro-BNP), is associated with the severity of the disease, and has been reported to be an independent predictor of outcome in CHF. We evaluated the effect of a four months group-based aerobic interval training program on circulating levels of NT pro-BNP in patients with CHF. We have previously reported improved functional capacity in 80 patients after exercise in this exercise program.

METHODS

Seventy-eight patients with stable CHF (21% women; 70+/-8 years; left ventricular ejection fraction 30+/-8.6%) on optimal medical treatment were randomized either to interval training (n=39), or to a control group (n=39). Circulating levels of NT pro-BNP, a six minute walk test (6MWT) and cycle ergometer test were evaluated at baseline, post exercise, and further after 12 months.

RESULTS

There were no significant differences in NT pro-BNP levels from baseline to either post exercise or long-term follow-up between or within the groups. Inverse correlations were observed between NT pro-BNP and 6MWT (r=-0.24, p=0.035) and cycle exercise time (r=-0.48, p<0.001) at baseline. But no significant correlations were observed between change in NT pro-BNP and change in functional capacity (6MWT; r=0.12, p=0.33, cycle exercise time; r=0.04, p=0.72).

CONCLUSION

No significant changes in NT pro-BNP levels were observed after interval training, despite significant improvement of functional capacity.

Authors+Show Affiliations

Oslo University Hospital, Ullevaal, Department of Cardiology, Norway. b.b.nilsson@medisin.uio.noNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20636229

Citation

Nilsson, Birgitta Blakstad, et al. "No Effect of Group-based Aerobic Interval Training On N-terminal Pro- B-type Natriuretic Peptide Levels in Patients With Chronic Heart Failure." Scandinavian Cardiovascular Journal : SCJ, vol. 44, no. 4, 2010, pp. 223-9.
Nilsson BB, Westheim A, Risberg MA, et al. No effect of group-based aerobic interval training on N-terminal pro- B-type natriuretic peptide levels in patients with chronic heart failure. Scand Cardiovasc J. 2010;44(4):223-9.
Nilsson, B. B., Westheim, A., Risberg, M. A., Arnesen, H., & Seljeflot, I. (2010). No effect of group-based aerobic interval training on N-terminal pro- B-type natriuretic peptide levels in patients with chronic heart failure. Scandinavian Cardiovascular Journal : SCJ, 44(4), 223-9. https://doi.org/10.3109/14017431.2010.496869
Nilsson BB, et al. No Effect of Group-based Aerobic Interval Training On N-terminal Pro- B-type Natriuretic Peptide Levels in Patients With Chronic Heart Failure. Scand Cardiovasc J. 2010;44(4):223-9. PubMed PMID: 20636229.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - No effect of group-based aerobic interval training on N-terminal pro- B-type natriuretic peptide levels in patients with chronic heart failure. AU - Nilsson,Birgitta Blakstad, AU - Westheim,Arne, AU - Risberg,May Arna, AU - Arnesen,Harald, AU - Seljeflot,Ingebjørg, PY - 2010/7/20/entrez PY - 2010/7/20/pubmed PY - 2010/11/3/medline SP - 223 EP - 9 JF - Scandinavian cardiovascular journal : SCJ JO - Scand. Cardiovasc. J. VL - 44 IS - 4 N2 - OBJECTIVES: Exercise training might improve cardiac function as well as functional capacity in patients with chronic heart failure (CHF). N-terminal pro-B-type natriuretic peptide (NT pro-BNP), is associated with the severity of the disease, and has been reported to be an independent predictor of outcome in CHF. We evaluated the effect of a four months group-based aerobic interval training program on circulating levels of NT pro-BNP in patients with CHF. We have previously reported improved functional capacity in 80 patients after exercise in this exercise program. METHODS: Seventy-eight patients with stable CHF (21% women; 70+/-8 years; left ventricular ejection fraction 30+/-8.6%) on optimal medical treatment were randomized either to interval training (n=39), or to a control group (n=39). Circulating levels of NT pro-BNP, a six minute walk test (6MWT) and cycle ergometer test were evaluated at baseline, post exercise, and further after 12 months. RESULTS: There were no significant differences in NT pro-BNP levels from baseline to either post exercise or long-term follow-up between or within the groups. Inverse correlations were observed between NT pro-BNP and 6MWT (r=-0.24, p=0.035) and cycle exercise time (r=-0.48, p<0.001) at baseline. But no significant correlations were observed between change in NT pro-BNP and change in functional capacity (6MWT; r=0.12, p=0.33, cycle exercise time; r=0.04, p=0.72). CONCLUSION: No significant changes in NT pro-BNP levels were observed after interval training, despite significant improvement of functional capacity. SN - 1651-2006 UR - https://www.unboundmedicine.com/medline/citation/20636229/No_effect_of_group_based_aerobic_interval_training_on_N_terminal_pro__B_type_natriuretic_peptide_levels_in_patients_with_chronic_heart_failure_ L2 - http://www.tandfonline.com/doi/full/10.3109/14017431.2010.496869 DB - PRIME DP - Unbound Medicine ER -