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Lipoic acid alters amino acid neurotransmitters content in rat hippocampus after pilocarpine-induced seizures.
Fundam Clin Pharmacol. 2011 Aug; 25(4):485-92.FC

Abstract

This study was aimed at investigating the anticonvulsant activity of lipoic acid (LA) against pilocarpine-induced seizures as well as the effects of this metabolic antioxidant on the hippocampal extracellular concentrations of amino acid neurotransmitters glutamate, aspartate, glycine and glutamate and γ-aminobutyric acid (GABA). In vivo microdialysis demonstrated that an intraperitoneal administration of pilocarpine induced a pronounced increment of hippocampal glutamate and aspartate concentrations, whereas no significant change was observed in the levels of glycine or GABA. LA (10, 20 or 30 mg/kg) pretreatment completely blocked pilocarpine-evoked increases in extracellular glutamate and aspartate concentrations. Significant reductions in hippocampal GABA and glycine concentrations were also observed although not as pronounced as those shown by glutamate and aspartate. Based on the finding that LA protected rats against pilocarpine-induced seizures, it could be suggested that the reduction in inhibitory amino acid neurotransmitters levels was comparatively minor and offset by a more pronounced reduction in glutamate and aspartate extracellular concentrations. Therefore, the fact that LA could drastically reduce pilocarpine-induced increases in glutamate and aspartate should account, at least partly, for its anticonvulsant activity observed in pilocarpine-induced seizure in rats.

Authors+Show Affiliations

Laboratory of Experimental Research in Biological Sciences of Federal University of Piauí, Piauí, Brazil. rivelilson@pq.cnpq.brNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20636364

Citation

de Freitas, Rivelilson Mendes, et al. "Lipoic Acid Alters Amino Acid Neurotransmitters Content in Rat Hippocampus After Pilocarpine-induced Seizures." Fundamental & Clinical Pharmacology, vol. 25, no. 4, 2011, pp. 485-92.
de Freitas RM, de Oliveira Silva F, Saldanha GB, et al. Lipoic acid alters amino acid neurotransmitters content in rat hippocampus after pilocarpine-induced seizures. Fundam Clin Pharmacol. 2011;25(4):485-92.
de Freitas, R. M., de Oliveira Silva, F., Saldanha, G. B., & Jordán, J. (2011). Lipoic acid alters amino acid neurotransmitters content in rat hippocampus after pilocarpine-induced seizures. Fundamental & Clinical Pharmacology, 25(4), 485-92. https://doi.org/10.1111/j.1472-8206.2010.00862.x
de Freitas RM, et al. Lipoic Acid Alters Amino Acid Neurotransmitters Content in Rat Hippocampus After Pilocarpine-induced Seizures. Fundam Clin Pharmacol. 2011;25(4):485-92. PubMed PMID: 20636364.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Lipoic acid alters amino acid neurotransmitters content in rat hippocampus after pilocarpine-induced seizures. AU - de Freitas,Rivelilson Mendes, AU - de Oliveira Silva,Fábio, AU - Saldanha,Gláucio Barros, AU - Jordán,Joaquín, Y1 - 2010/07/15/ PY - 2010/7/20/entrez PY - 2010/7/20/pubmed PY - 2012/1/25/medline SP - 485 EP - 92 JF - Fundamental & clinical pharmacology JO - Fundam Clin Pharmacol VL - 25 IS - 4 N2 - This study was aimed at investigating the anticonvulsant activity of lipoic acid (LA) against pilocarpine-induced seizures as well as the effects of this metabolic antioxidant on the hippocampal extracellular concentrations of amino acid neurotransmitters glutamate, aspartate, glycine and glutamate and γ-aminobutyric acid (GABA). In vivo microdialysis demonstrated that an intraperitoneal administration of pilocarpine induced a pronounced increment of hippocampal glutamate and aspartate concentrations, whereas no significant change was observed in the levels of glycine or GABA. LA (10, 20 or 30 mg/kg) pretreatment completely blocked pilocarpine-evoked increases in extracellular glutamate and aspartate concentrations. Significant reductions in hippocampal GABA and glycine concentrations were also observed although not as pronounced as those shown by glutamate and aspartate. Based on the finding that LA protected rats against pilocarpine-induced seizures, it could be suggested that the reduction in inhibitory amino acid neurotransmitters levels was comparatively minor and offset by a more pronounced reduction in glutamate and aspartate extracellular concentrations. Therefore, the fact that LA could drastically reduce pilocarpine-induced increases in glutamate and aspartate should account, at least partly, for its anticonvulsant activity observed in pilocarpine-induced seizure in rats. SN - 1472-8206 UR - https://www.unboundmedicine.com/medline/citation/20636364/Lipoic_acid_alters_amino_acid_neurotransmitters_content_in_rat_hippocampus_after_pilocarpine_induced_seizures_ L2 - https://doi.org/10.1111/j.1472-8206.2010.00862.x DB - PRIME DP - Unbound Medicine ER -