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Snoring and insomnia are not associated with subclinical atherosclerosis in the Northern Manhattan Study.
Int J Stroke 2010; 5(4):264-8IJ

Abstract

BACKGROUND

Sleep-disordered breathing is a risk factor for stroke, but its association with subclinical atherosclerosis remains controversial. Snoring and insomnia are frequently comorbid with sleep-disordered breathing and may contribute to stroke. Data on the relationship between snoring and insomnia with atherosclerotic disease are sparse. We investigated the relationship between markers of subclinical atherosclerosis, insomnia, snoring, and carotid intima-media thickness, in the Northern Manhattan Study.

METHODS

A group of 1605 participants (mean age 65 +/- 8 years; 40% men; 61% Hispanic, 19% black, 20% white) who had carotid intima-media thickness measurements performed was assessed for self-reported sleep habits. Habitual snoring was defined as self-reported snoring greater than four times per week. Presence of insomnia was based on three items extracted from the Hamilton Rating Scale for Depression. Carotid intima-media thickness was expressed as a mean composite measure of intima-media thickness in the carotid bifurcation, common, and internal carotid artery. Multivariate linear regression models were used to identify associations between snoring, insomnia, and carotid intima-media thickness.

RESULTS

Habitual snoring was present in 29% of the subjects and insomnia in 26%. There was a higher prevalence of self-reported snoring (84%) and insomnia (66%) among Hispanics than non-Hispanics. The mean total carotid intima-media thickness was 0.95 +/- 0.09 mm; among those with self-reported snoring was 0.94 +/- 0.09 mm; and among those with insomnia was 0.95 +/- 0.08 mm. After controlling for age, gender, race-ethnicity, body mass index and cardiovascular risk factors, snoring (P=0.986) and insomnia (P=0.829) were not significantly associated with increased carotid intima-media thickness.

CONCLUSION

Snoring and insomnia were not significantly associated with subclinical atherosclerosis in this population-based community cohort.

Authors+Show Affiliations

Department of Neurology, Miller School of Medicine, University of Miami Miller School of Medicine, Miami, FL 33136, USA. aramos@med.miami.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

20636708

Citation

Ramos-Sepulveda, Alberto, et al. "Snoring and Insomnia Are Not Associated With Subclinical Atherosclerosis in the Northern Manhattan Study." International Journal of Stroke : Official Journal of the International Stroke Society, vol. 5, no. 4, 2010, pp. 264-8.
Ramos-Sepulveda A, Wohlgemuth W, Gardener H, et al. Snoring and insomnia are not associated with subclinical atherosclerosis in the Northern Manhattan Study. Int J Stroke. 2010;5(4):264-8.
Ramos-Sepulveda, A., Wohlgemuth, W., Gardener, H., Lorenzo, D., Dib, S., Wallace, D. M., ... Rundek, T. (2010). Snoring and insomnia are not associated with subclinical atherosclerosis in the Northern Manhattan Study. International Journal of Stroke : Official Journal of the International Stroke Society, 5(4), pp. 264-8. doi:10.1111/j.1747-4949.2010.00438.x.
Ramos-Sepulveda A, et al. Snoring and Insomnia Are Not Associated With Subclinical Atherosclerosis in the Northern Manhattan Study. Int J Stroke. 2010;5(4):264-8. PubMed PMID: 20636708.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Snoring and insomnia are not associated with subclinical atherosclerosis in the Northern Manhattan Study. AU - Ramos-Sepulveda,Alberto, AU - Wohlgemuth,William, AU - Gardener,Hannah, AU - Lorenzo,Dalia, AU - Dib,Salim, AU - Wallace,Douglas M, AU - Nolan,Bruce, AU - Boden-Albala,Bernadette, AU - Elkind,Mitchell S V, AU - Sacco,Ralph L, AU - Rundek,Tatjana, PY - 2010/7/20/entrez PY - 2010/7/20/pubmed PY - 2010/10/29/medline SP - 264 EP - 8 JF - International journal of stroke : official journal of the International Stroke Society JO - Int J Stroke VL - 5 IS - 4 N2 - BACKGROUND: Sleep-disordered breathing is a risk factor for stroke, but its association with subclinical atherosclerosis remains controversial. Snoring and insomnia are frequently comorbid with sleep-disordered breathing and may contribute to stroke. Data on the relationship between snoring and insomnia with atherosclerotic disease are sparse. We investigated the relationship between markers of subclinical atherosclerosis, insomnia, snoring, and carotid intima-media thickness, in the Northern Manhattan Study. METHODS: A group of 1605 participants (mean age 65 +/- 8 years; 40% men; 61% Hispanic, 19% black, 20% white) who had carotid intima-media thickness measurements performed was assessed for self-reported sleep habits. Habitual snoring was defined as self-reported snoring greater than four times per week. Presence of insomnia was based on three items extracted from the Hamilton Rating Scale for Depression. Carotid intima-media thickness was expressed as a mean composite measure of intima-media thickness in the carotid bifurcation, common, and internal carotid artery. Multivariate linear regression models were used to identify associations between snoring, insomnia, and carotid intima-media thickness. RESULTS: Habitual snoring was present in 29% of the subjects and insomnia in 26%. There was a higher prevalence of self-reported snoring (84%) and insomnia (66%) among Hispanics than non-Hispanics. The mean total carotid intima-media thickness was 0.95 +/- 0.09 mm; among those with self-reported snoring was 0.94 +/- 0.09 mm; and among those with insomnia was 0.95 +/- 0.08 mm. After controlling for age, gender, race-ethnicity, body mass index and cardiovascular risk factors, snoring (P=0.986) and insomnia (P=0.829) were not significantly associated with increased carotid intima-media thickness. CONCLUSION: Snoring and insomnia were not significantly associated with subclinical atherosclerosis in this population-based community cohort. SN - 1747-4949 UR - https://www.unboundmedicine.com/medline/citation/20636708/Snoring_and_insomnia_are_not_associated_with_subclinical_atherosclerosis_in_the_Northern_Manhattan_Study_ L2 - http://journals.sagepub.com/doi/full/10.1111/j.1747-4949.2010.00438.x?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -