Tags

Type your tag names separated by a space and hit enter

Association between cardiac autonomic neuropathy and hypertension and its potential influence on diabetic complications.
Diabet Med. 2010 Jul; 27(7):804-11.DM

Abstract

AIMS

To examine the association between cardiac autonomic neuropathy and hypertension and the role of this association in diabetic complications.

METHODS

We included 310 patients, 138 with Type 1 and 172 with Type 2 diabetes, 62 of them with hypertension. Cardiac autonomic neuropathy was assessed by analysing heart rate variations during three standard tests (deep breathing, lying to standing and Valsalva) and looking for postural hypotension.

RESULTS

Cardiac autonomic neuropathy was present in 123 patients and 39 also had hypertension. The prevalence of a cardiac autonomic neuropathy/hypertension association was higher in Type 2 patients (P < 0.002). The prevalence of hypertension increased with the severity of cardiac autonomic neuropathy. In multiple logistic regression analysis, cardiac autonomic neuropathy was an independent risk factor for hypertension [odds ratio 2.86 (1.54-5.32); P < 0.001]. Only confirmed or severe cardiac autonomic neuropathy (two or more abnormal function tests, respectively) were independent risk factors for hypertension (P < 0.005 and < 0.0001). Cardiac autonomic neuropathy was found in most of the patients with macrovascular complications, retinopathy or nephropathy, but a large majority of the patients with these complications exhibited the cardiac autonomic neuropathy/hypertension profile. This profile was more prevalent among the patients with coronary or peripheral artery disease or antecedent stroke than among those free of these complications (P < 0.001). In logistic regression analyses, the cardiac autonomic neuropathy/hypertension profile associated significantly with macro- and microvascular complications.

CONCLUSIONS

These data are strongly in favour of the role of cardiac autonomic neuropathy in hypertension in diabetic patients. The association of the cardiac autonomic neuropathy/hypertension profile with vascular complications is consistent with a deleterious effect on vascular hemodynamics and structure, additional to the effects of hypertension.

Authors+Show Affiliations

Department of Internal Medicine, University Hospital, Oran, Algeria.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

20636962

Citation

Ayad, F, et al. "Association Between Cardiac Autonomic Neuropathy and Hypertension and Its Potential Influence On Diabetic Complications." Diabetic Medicine : a Journal of the British Diabetic Association, vol. 27, no. 7, 2010, pp. 804-11.
Ayad F, Belhadj M, Pariés J, et al. Association between cardiac autonomic neuropathy and hypertension and its potential influence on diabetic complications. Diabet Med. 2010;27(7):804-11.
Ayad, F., Belhadj, M., Pariés, J., Attali, J. R., & Valensi, P. (2010). Association between cardiac autonomic neuropathy and hypertension and its potential influence on diabetic complications. Diabetic Medicine : a Journal of the British Diabetic Association, 27(7), 804-11. https://doi.org/10.1111/j.1464-5491.2010.03027.x
Ayad F, et al. Association Between Cardiac Autonomic Neuropathy and Hypertension and Its Potential Influence On Diabetic Complications. Diabet Med. 2010;27(7):804-11. PubMed PMID: 20636962.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association between cardiac autonomic neuropathy and hypertension and its potential influence on diabetic complications. AU - Ayad,F, AU - Belhadj,M, AU - Pariés,J, AU - Attali,J R, AU - Valensi,P, PY - 2010/7/20/entrez PY - 2010/7/20/pubmed PY - 2012/1/11/medline SP - 804 EP - 11 JF - Diabetic medicine : a journal of the British Diabetic Association JO - Diabet Med VL - 27 IS - 7 N2 - AIMS: To examine the association between cardiac autonomic neuropathy and hypertension and the role of this association in diabetic complications. METHODS: We included 310 patients, 138 with Type 1 and 172 with Type 2 diabetes, 62 of them with hypertension. Cardiac autonomic neuropathy was assessed by analysing heart rate variations during three standard tests (deep breathing, lying to standing and Valsalva) and looking for postural hypotension. RESULTS: Cardiac autonomic neuropathy was present in 123 patients and 39 also had hypertension. The prevalence of a cardiac autonomic neuropathy/hypertension association was higher in Type 2 patients (P < 0.002). The prevalence of hypertension increased with the severity of cardiac autonomic neuropathy. In multiple logistic regression analysis, cardiac autonomic neuropathy was an independent risk factor for hypertension [odds ratio 2.86 (1.54-5.32); P < 0.001]. Only confirmed or severe cardiac autonomic neuropathy (two or more abnormal function tests, respectively) were independent risk factors for hypertension (P < 0.005 and < 0.0001). Cardiac autonomic neuropathy was found in most of the patients with macrovascular complications, retinopathy or nephropathy, but a large majority of the patients with these complications exhibited the cardiac autonomic neuropathy/hypertension profile. This profile was more prevalent among the patients with coronary or peripheral artery disease or antecedent stroke than among those free of these complications (P < 0.001). In logistic regression analyses, the cardiac autonomic neuropathy/hypertension profile associated significantly with macro- and microvascular complications. CONCLUSIONS: These data are strongly in favour of the role of cardiac autonomic neuropathy in hypertension in diabetic patients. The association of the cardiac autonomic neuropathy/hypertension profile with vascular complications is consistent with a deleterious effect on vascular hemodynamics and structure, additional to the effects of hypertension. SN - 1464-5491 UR - https://www.unboundmedicine.com/medline/citation/20636962/Association_between_cardiac_autonomic_neuropathy_and_hypertension_and_its_potential_influence_on_diabetic_complications_ L2 - https://doi.org/10.1111/j.1464-5491.2010.03027.x DB - PRIME DP - Unbound Medicine ER -