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[Relationship between nonalcoholic fatty liver disease and cardiovascular disease in children with obesity].
Zhongguo Dang Dai Er Ke Za Zhi 2010; 12(7):547-50ZD

Abstract

OBJECTIVE

To study the relationship between nonalcoholic fatty liver disease (NAFLD) and the development of cardiovascular disease (CVD) in children with obesity.

METHODS

Two hundred and thirty-one obese children and 24 non-obese children as control were enrolled. Body mass index (BMI), serum triglyceride, blood pressure, liver function, and carotid artery intima-media thickness (IMT) were examined. The obese children were classified into two subgroups according to the diagnosis criteria: group 1 without liver disorder (OCWLD group, n=75) and group 2 with NAFLD (NAFLD group, n=156). The incidences of hyperlipidemia and hypertension, carotid artery intima-media thickness (IMT) and biochemical indicators were compared in the three groups.

RESULTS

The NAFLD group showed significantly greater carotid IMT (0.066+/-0.021 cm) than the OCWLD (0.060+/-0.011 cm) and control groups (0.037+/-0.007 cm) (P<0.05). The OCWLD group had also thicker IMT than the control group (P<0.05). The incidences of hyperlipidemia and hypertension were 39.7% and 40.4%, respectively in the NAFLD group, which were significantly higher than those in the OCWLD (22.7% and 29.3% respectively)and control groups (4.2% and 12.6% respectively) (P<0.05). The liner stepwise regression analysis showed that the IMT was positively correlated with BMI, NAFLD and ALT (adjusted R2=0.316, P<0.01).

CONCLUSIONS

NAFLD may be not only an early marker but also an early state of CVD in obese children. Early diagnosis and treatment of NAFLD is crucial for the prevention of the occurrence and development of CVD.

Authors+Show Affiliations

Department of Endocrinology, Children's Hospital of Zhejiang University School of Medicine, Hangzhou 310003, China.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

chi

PubMed ID

20637154

Citation

Liu, Li-Rui, et al. "[Relationship Between Nonalcoholic Fatty Liver Disease and Cardiovascular Disease in Children With Obesity]." Zhongguo Dang Dai Er Ke Za Zhi = Chinese Journal of Contemporary Pediatrics, vol. 12, no. 7, 2010, pp. 547-50.
Liu LR, Fu JF, Liang L, et al. [Relationship between nonalcoholic fatty liver disease and cardiovascular disease in children with obesity]. Zhongguo Dang Dai Er Ke Za Zhi. 2010;12(7):547-50.
Liu, L. R., Fu, J. F., Liang, L., & Huang, K. (2010). [Relationship between nonalcoholic fatty liver disease and cardiovascular disease in children with obesity]. Zhongguo Dang Dai Er Ke Za Zhi = Chinese Journal of Contemporary Pediatrics, 12(7), pp. 547-50.
Liu LR, et al. [Relationship Between Nonalcoholic Fatty Liver Disease and Cardiovascular Disease in Children With Obesity]. Zhongguo Dang Dai Er Ke Za Zhi. 2010;12(7):547-50. PubMed PMID: 20637154.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Relationship between nonalcoholic fatty liver disease and cardiovascular disease in children with obesity]. AU - Liu,Li-Rui, AU - Fu,Jun-Fen, AU - Liang,Li, AU - Huang,Ke, PY - 2010/7/20/entrez PY - 2010/7/20/pubmed PY - 2010/10/12/medline SP - 547 EP - 50 JF - Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics JO - Zhongguo Dang Dai Er Ke Za Zhi VL - 12 IS - 7 N2 - OBJECTIVE: To study the relationship between nonalcoholic fatty liver disease (NAFLD) and the development of cardiovascular disease (CVD) in children with obesity. METHODS: Two hundred and thirty-one obese children and 24 non-obese children as control were enrolled. Body mass index (BMI), serum triglyceride, blood pressure, liver function, and carotid artery intima-media thickness (IMT) were examined. The obese children were classified into two subgroups according to the diagnosis criteria: group 1 without liver disorder (OCWLD group, n=75) and group 2 with NAFLD (NAFLD group, n=156). The incidences of hyperlipidemia and hypertension, carotid artery intima-media thickness (IMT) and biochemical indicators were compared in the three groups. RESULTS: The NAFLD group showed significantly greater carotid IMT (0.066+/-0.021 cm) than the OCWLD (0.060+/-0.011 cm) and control groups (0.037+/-0.007 cm) (P<0.05). The OCWLD group had also thicker IMT than the control group (P<0.05). The incidences of hyperlipidemia and hypertension were 39.7% and 40.4%, respectively in the NAFLD group, which were significantly higher than those in the OCWLD (22.7% and 29.3% respectively)and control groups (4.2% and 12.6% respectively) (P<0.05). The liner stepwise regression analysis showed that the IMT was positively correlated with BMI, NAFLD and ALT (adjusted R2=0.316, P<0.01). CONCLUSIONS: NAFLD may be not only an early marker but also an early state of CVD in obese children. Early diagnosis and treatment of NAFLD is crucial for the prevention of the occurrence and development of CVD. SN - 1008-8830 UR - https://www.unboundmedicine.com/medline/citation/20637154/[Relationship_between_nonalcoholic_fatty_liver_disease_and_cardiovascular_disease_in_children_with_obesity]_ L2 - http://www.zgddek.com/EN/abstract/abstract12314.shtml DB - PRIME DP - Unbound Medicine ER -